Blood Culture From The Umbilical Vein In The Diagnosis Of Neonatal Sepsis.

Fos, N Izquierdo; Gomis, RM Vázquez; Gomis, Consuelo Vázquez; Rubio, JMa; Justich, Pablo; Valera, JA Carmona; Chicano, FJ; Borrajo, E

doi:10.5580/6f0

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…Cord blood is used for blood type, antibody screen, and chromosome analysis (6). Utilizing cord blood in high-risk infants to obtain blood cultures has been shown to increase the etiological diagnosis of sepsis (7). Umbilical cord blood culture (UCBC) has a sensitivity between 80 and 100% and specificity between 91.4 and 94.9% when compared to PBC for the diagnosis of sepsis in high-risk newborns (8).…”

Section: Introductionmentioning

confidence: 99%

Eliminating Contamination in Umbilical Cord Blood Culture Sampling for Early-Onset Neonatal Sepsis

et al. 2021

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Introduction: Despite the advantages of umbilical cord blood culture (UCBC) use for diagnosis of early onset sepsis (EOS), contamination rates have deterred neonatologists from its widespread use. We aimed to implement UCBC collection in a level III neonatal intensive care unit (NICU) and apply quality improvement (QI) methods to reduce contamination in the diagnosis of early onset sepsis.Methods: Single-center implementation study utilizing quality improvement methodology to achieve 0% contamination rate in UCBC samples using the Plan-Do-Study-Act (PDSA) model for improvement. UCBC was obtained in conjunction with peripheral blood cultures (PBC) in neonates admitted to the NICU due to maternal chorioamnionitis. Maternal and neonatal characteristics between clinical sepsis and asymptomatic groups were compared. Process, outcome, and balancing measures were monitored.Results: Eighty-two UCBC samples were collected in addition to peripheral blood culture from neonates admitted due to maternal chorioamnionitis. Ten (12%) neonates had a diagnosis of clinical sepsis. All PBCs were negative and 5 UCBCs were positive in the study period. After 2 PDSA cycles, there was special cause variation with improvement in the percent of contaminated samples from 7.3 to 0%. There was no change in antibiotic duration among asymptomatic neonates.Conclusions: Implementation of UCBC for the diagnosis of EOS in term infants is feasible and contamination can be minimized with the implementation of a core team of trained providers and a proper sterile technique without increasing antibiotic duration.

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Section: Introductionmentioning

confidence: 99%

Eliminating Contamination in Umbilical Cord Blood Culture Sampling for Early-Onset Neonatal Sepsis

et al. 2021

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Evaluation of Cord Blood Culture as an Early Predictor for the Detection of Early Onset Neonatal Sepsis in Tertiary Centre of Central India.

Shukla

Channa

2021

Global Journal for Research Analysis

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BACKGROUND : Neonatal sepsis is one of the major causes of neonatal morbidity and mortality. Peripheral venous blood culture and sensitivity is gold standard for the diagnosis of neonatal sepsis. Low sensitivity of blood culture in newborn is due to small volume of blood sample collected from neonates & antibiotics given before sampling. AIM : To evaluate the utility & compare the Umblical cord blood culture(UCBC) with Peripheral venous blood culture(PVBC) for detection of Early Onset Neonatal Sepsis(EONS) METHOD : 100 inborn neonates with two or more risk factors for EONS, chosen by sequential sampling method were included in this prospective analytical study. Blood samples were collected from umbilical cord and peripheral vein for culture. Sepsis screen was done to corroborate the diagnosis of neonatal sepsis. RESULT : Out of 100 neonates, 21 belongs to sepsis; 14 to probable sepsis; 65 to no sepsis. UCBC had Sensitivity-65.71% , Specicity-93.84%, PPV-85.18% , NPV-83.56% & PVBC had Sensitivity-60% , Specicity-95.38% , PPV-87.5% , NPV-81.57%. CONCLUSION : UCBC is simple and convenient method for the diagnosis of EONS compared to PVBC. Organisms grown are comparable to PVBC sample.

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Study of umbilical cord blood culture in diagnosis of early-onset sepsis among newborns with high-risk factors

Kalathia¹,

Shingala²,

Parmar³

et al. 2013

J Clin Neonatol

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Context:Blood culture is gold standard for diagnosis of neonatal sepsis. Low sensitivity of blood culture is usually due to small volume of blood sample, intrapartum antibiotics, and antibiotics given to newborn before sampling.Aim:We evaluated use of Umbilical cord blood culture (UCBC) in diagnosis of neonatal sepsis as compared to peripheral venous blood culture.Settings and Design:This study was done in tertiary care teaching hospital during May-June 2012. A total of 45 newborns with presence of two or more risk factors of sepsis were included.Subjects and Methods:Blood sample from placental end of umbilical cord was collected and cultured. Primary outcome was diagnosis of neonatal sepsis by use of umbilical cord blood sample as compared with venous blood sample. Secondary outcome was to compare organisms identified by UCBC and venous blood culture.Statistical Analysis:Sensitivity, specificity, positive and negative predictive values of UCBC were calculated.Results:A total of 24.44% (11 out of 45) high-risk newborns had positive UCBC. A total of 17.8% (8 out of 45) newborns had positive blood culture report. Organisms grown in UCBC were Pseudomonas (45%, 5 out of 11), Acinetobacter (27.27%, 3 out of 11), Escherichia coli (18.18%, 2 out of 11), and Klebsiella (9%, 1 out of 11).Conclusion:UCBC is a good method for diagnosis of neonatal sepsis among high-risk newborns as compared to venous blood culture with a sensitivity of 80% and specificity of 91.43%. Organisms grown are comparable to blood culture samples.

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Blood Culture From The Umbilical Vein In The Diagnosis Of Neonatal Sepsis.

Cited by 3 publications

References 9 publications

Eliminating Contamination in Umbilical Cord Blood Culture Sampling for Early-Onset Neonatal Sepsis

Eliminating Contamination in Umbilical Cord Blood Culture Sampling for Early-Onset Neonatal Sepsis

Evaluation of Cord Blood Culture as an Early Predictor for the Detection of Early Onset Neonatal Sepsis in Tertiary Centre of Central India.

Study of umbilical cord blood culture in diagnosis of early-onset sepsis among newborns with high-risk factors

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