Abstract:OBJECTIVE:The objective of this study was to verify whether the parameters of the blood count and the fasting glucose level before treatment are related to prognosis and survival in cervical cancer (IIB-IVB staging). METHODS: Patients with cervical cancer (stages IIB-IVB) were evaluated (n=80). Age, parity, staging, histological grade, histological type, hemoglobin, red blood cells, hematocrit, neutrophil, lymphocyte and platelet counts, red blood cell distribution width, neutrophil-lymphocyte ratio, plateletl… Show more
“…In our study, we also evaluated other pertinent markers, including ALB, AGR, total protein, Hb, and BMI, which have previously been reported as indicative of survival in CRC. Moreover, we introduced red blood cell count (RBC) as an additional marker, despite limited research evidence, which has demonstrated its potential for predicting the long-term prognosis of hepatocellular carcinoma and cervical cancer [13,30]. However, its speci c role in prognostic assessment for CRC patients remains an area warranting further investigation.…”
Background
Colorectal Cancer (CRC) is a major global malignancy with significant morbidity and mortality rates. Accurate prognostic assessment plays a vital role in the management of CRC patients. In this study, we aimed to investigate the prognostic significance of red blood cell count (RBC), and develop a comprehensive biomarker based on RBC and Onodera’s prognostic nutritional index (OPNI) to predict the prognosis of resectable CRC patients.
Methods
We retrospectively reviewed a cohort of 210 CRC patients who underwent radical resection between January 2015 and January 2017. Various clinical and hematological factors were assessed, including RBC, albumin, hemoglobin, and OPNI. A novel comprehensive biomarker, R-OPNI, was introduced, combining preoperative RBC with OPNI. The correlation between these factors and patient survival was analyzed, and the independent prognostic value of R-OPNI was assessed based on univariate and multivariate Cox models.
Results
Patients with higher RBC levels (≥ 3.9 x1012/L) experienced significantly improved overall survival compared to those with lower RBC levels (p < 0.001). High OPNI values were also associated with prolonged survival (p < 0.001). Notably, patients with lower R-OPNI scores (0 or 1) had notably poorer overall survival (p < 0.001). Multivariate analysis confirmed R-OPNI's independent prognostic significance (HR: 0.273, 95% CI: 0.098–0.763, p = 0.013). Furthermore, factors such as tumor site, albumin levels, albumin to globulin ratio, hemoglobin levels, and total protein levels demonstrated significant prognostic value in CRC survival.
Conclusion
R-OPNI is significantly associated with the survival of resectable CRC patients and serves as an independent prognostic predictor. The study also highlights the prognostic importance of RBC in CRC and emphasizes the value of assessing the preoperative nutritional status.
“…In our study, we also evaluated other pertinent markers, including ALB, AGR, total protein, Hb, and BMI, which have previously been reported as indicative of survival in CRC. Moreover, we introduced red blood cell count (RBC) as an additional marker, despite limited research evidence, which has demonstrated its potential for predicting the long-term prognosis of hepatocellular carcinoma and cervical cancer [13,30]. However, its speci c role in prognostic assessment for CRC patients remains an area warranting further investigation.…”
Background
Colorectal Cancer (CRC) is a major global malignancy with significant morbidity and mortality rates. Accurate prognostic assessment plays a vital role in the management of CRC patients. In this study, we aimed to investigate the prognostic significance of red blood cell count (RBC), and develop a comprehensive biomarker based on RBC and Onodera’s prognostic nutritional index (OPNI) to predict the prognosis of resectable CRC patients.
Methods
We retrospectively reviewed a cohort of 210 CRC patients who underwent radical resection between January 2015 and January 2017. Various clinical and hematological factors were assessed, including RBC, albumin, hemoglobin, and OPNI. A novel comprehensive biomarker, R-OPNI, was introduced, combining preoperative RBC with OPNI. The correlation between these factors and patient survival was analyzed, and the independent prognostic value of R-OPNI was assessed based on univariate and multivariate Cox models.
Results
Patients with higher RBC levels (≥ 3.9 x1012/L) experienced significantly improved overall survival compared to those with lower RBC levels (p < 0.001). High OPNI values were also associated with prolonged survival (p < 0.001). Notably, patients with lower R-OPNI scores (0 or 1) had notably poorer overall survival (p < 0.001). Multivariate analysis confirmed R-OPNI's independent prognostic significance (HR: 0.273, 95% CI: 0.098–0.763, p = 0.013). Furthermore, factors such as tumor site, albumin levels, albumin to globulin ratio, hemoglobin levels, and total protein levels demonstrated significant prognostic value in CRC survival.
Conclusion
R-OPNI is significantly associated with the survival of resectable CRC patients and serves as an independent prognostic predictor. The study also highlights the prognostic importance of RBC in CRC and emphasizes the value of assessing the preoperative nutritional status.
“…The ratio of Hb to RDW (HRR) is a convenient prognostic marker for small cell lung cancer (SCLC), non-small cell lung cancer (NSCLC), and pulmonary large cell neuroendocrine carcinoma (PLCNEC) (Zhao et al, 2022). The combination of RDW, weight loss, and the metastatic lymph nodes were risk factors for the poor survival of patients with advanced oral cancer independent of other clinical and pathological characteristics (Trevisani et al, 2021) platelet-lymphocyte ratio > 184.9, and higher fasting glucose level, (Mota et al, 2022) the increased RDW-to-albumin ratio is independently associated with increased all-cause mortality in cancer patients (Lu et al, 2022).…”
Section: Cancersmentioning
confidence: 99%
“…The combination of RDW, weight loss, and the metastatic lymph nodes were risk factors for the poor survival of patients with advanced oral cancer independent of other clinical and pathological characteristics (Trevisani et al, 2021). Although shorter overall survival and disease‐free survival are associated with Hb ≤ 12.3 g/dL, hematocrit ≤ 38.5%, neutrophil–lymphocyte ratio > 2.9, platelet–lymphocyte ratio > 184.9, and higher fasting glucose level, (Mota et al, 2022) the increased RDW‐to‐albumin ratio is independently associated with increased all‐cause mortality in cancer patients (Lu et al, 2022).…”
Section: The Application Of Rdw In the Diagnosis Of Nonanemic Diseasesmentioning
Many indicators, including red cell distribution width (RDW) and iron metabolism, are sensitive to a variety of risk factors, and are associated with the pathological alterations and disease onset. RDW reflects the degree of heterogeneous volumes of peripheral red blood cells (RBCs). It has been well‐known that increased RDW indicates iron deficiency anemia, hemolytic anemia, ineffective erythropoiesis, and shorten lifespan of RBCs. Increased RDW is also prevalent in various non‐anemic pathological conditions and diseases. We here review the factors affecting RDW, particularly disordered iron metabolism, chronic inflammation, and oxidative stress, and recapitulate the interplays among these factors. Furthermore, we review the application of increased RDW together with disordered iron homeostasis and the deregulations of hepcidin expression and ferritin levels in the diagnoses and prognosis of anemic and nonanemic diseases. RDW is inexpensive and readily available and may be valuable in adding to the diagnosis and monitoring of many pathological conditions. RDW combined with other indicators, for example, hepcidin and ferritin levels, should be utilized more frequently in clinical practice.
Background
Cervical cancer is a tumor with high morbidity and mortality. The importance of inflammatory and metabolic parameters affecting progression-free survival (PFS) and overall survival (OS) has been investigated more intensively recently. We aimed to investigate the effect of glucose/c-reactive protein (CRP) ratio [GCR], which shows these two parameters together, on PFS in cervical cancer.
Methods
We retrospectively included 90 patients with adenocarcinoma and squamous cell carcinoma of the cervix. The effects of clinical variables, inflammatory and glycemic parameters on PFS and OS were analyzed by Kaplan-Meier method. The data were compared with the healthy control group of 90 individuals using the independent t test. The effect of parameters on mortality was analyzed using ROC curves and cut off values were determined.
Results
Glucose, CRP, CRP/lymphocyte ratio (CLR) and GCR were statistically significant in predicting mortality (p < 0.05). Disease stage, glucose, CRP, CLR and GCR were associated with overall survival. CRP, CLR and GCR were associated with progression-free survival (p < 0.05). In multivariate analysis, GCR was prognostic for PFS (p = 0.025). GCR was statistically significant while compared with the patient and healthy control group (p < 0.001).
Conclusion
In cervical cancer, GCR rate was found to be prognostic independent of stage. Higher GCR rate was associated with longer PFS duration.
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