Blood component transfusions in mass casualty events

Ramsey, Glenn

doi:10.1111/vox.12564

Cited by 16 publications

(15 citation statements)

References 36 publications

(15 reference statements)

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“…In large mass casualty events analyzed from 1980 to 2016, the 75th percentiles for units transfused per admission were 3.9 units of RBCs, 3.6 units of plasma, and 0.48 platelet doses. Most blood products were needed within the first 12 to 24 hours (medians: RBCs, 67%; plasma, 75%; platelets, 84%) . Several areas for improvement during mass casualty events include specimen and patient identification, expediting ABO/Rh typing, allocation of group O RBCs, and communication.…”

Section: Transfusion Approaches To Hemorrhagic Shock and Mass Casualtiesmentioning

confidence: 99%

“…Most blood products were needed within the first 12 to 24 hours (medians: RBCs, 67%; plasma, 75%; platelets, 84%). 67 Several areas for improvement during mass casualty events include 68 specimen and patient identification, 61,63 expediting ABO/Rh typing, 61,68 allocation of group O RBCs, and communication. The need for improved communication was frequently noted between blood suppliers and hospitals, 63,69 between blood suppliers and regional emergency management systems (to expedite sending blood components to hospitals receiving patients), 61 and between blood suppliers and the public and media, with regard to the need (or not) for blood donations.…”

Section: Transfusion Approaches To Hemorrhagic Shock and Mass Casualtiesmentioning

confidence: 99%

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Critical developments of 2018: A review of the literature from selected topics in transfusion. A committee report from the AABB's Clinical Transfusion Medicine Committee

et al. 2019

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RESULTS:The following topics are covered: "big data"and "omics" studies, emerging infections and testing, platelet transfusion and pathogen reduction, transfusion therapy and coagulation, transfusion approach to hemorrhagic shock and mass casualties, therapeutic apheresis, and chimeric antigen receptor T-cell therapy. CONCLUSION:This synopsis may be a useful educational tool. ABBREVIATIONS: ARC = American Red Cross; CAR = chimeric antigen receptor; CJD = Creutzfeldt-Jakob disease; CRS = cytokine release syndrome; DENV = Dengue virus; FDA = US Food and Drug Administration; IgM = immunoglobulin M; IRIS = immune reconstitution inflammatory syndrome; NAT = nucleic acid testing; NTZ = natalizumab; NTZ-PML = NTZ-associated PML; PAS = platelets in additive solution; PCR = polymerase chain reaction; PML = progressive multifocal leukoencephalopathy; PR = pathogen reduction; RCT = randomized controlled trial; TMA = transcriptionmediated amplification; TPE = therapeutic plasma exchange; TTP = thrombotic thrombocytopenic purpura; ZIKV = Zika virus. From the

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Section: Transfusion Approaches To Hemorrhagic Shock and Mass Casualtiesmentioning

confidence: 99%

Section: Transfusion Approaches To Hemorrhagic Shock and Mass Casualtiesmentioning

confidence: 99%

Critical developments of 2018: A review of the literature from selected topics in transfusion. A committee report from the AABB's Clinical Transfusion Medicine Committee

et al. 2019

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“…Recent reviews of MCEs have highlighted once more that only a modest number of hospitalized patients require transfusion following MCEs . However, a small number of critically injured with multi‐trauma may require emergency transfusion as part of ‘Damage Control Resuscitation’ (DCR).…”

Section: Transfusion For Traumamentioning

confidence: 99%

“…The mean blood use in those patients treated with massive transfusions was red‐blood‐cells 7·6 units, Octaplas 5·6 and 2 Adult Therapeutic Doses (pools of 4) of platelets. These recent incidents were included in a review by Ramsey in September 2017 . The careful mathematical treatment of MCEs since 1980 led him to conclude that the average use of components per all admitted patients was 3·06 units of red cells together with 2·13 units of plasma and 0·37 platelet doses.…”

Section: Transfusion Demand Planning For Mcesmentioning

confidence: 99%

Transfusion emergency preparedness for mass casualty events

Doughty

Rackham

2018

ISBT Science Series

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Transfusion emergency preparedness is increasingly being recognized as an important element in the healthcare response to mass casualty events (MCE). Planning should be designed to support an integrated response between the blood services and hospitals. The lessons identified from the Manchester Arena bombing in 2017 and recent incidents in London have led to new guidance. Demand planning has been informed by the global experience of civilian MCEs and the changing trends in trauma care. Past evidence suggests that only a modest number of hospitalized patients following MCEs require transfusion. The mean blood use per patient admitted is consistently calculated at 2–3 red cell units. Most blood is used within the first 6 h. However, a small number of critically injured with multi‐trauma may require massive transfusion and ongoing support. Many blood services have reported meeting the initial overall demand for blood from stock. However, universal components may be in short supply. The demand can be managed by pre‐agreed substitutions. Early transfusion triage enables the best use of hospital laboratory and blood service support. Careful communication with donor communities is essential to manage a controlled replenishment of stocks. Future challenges for the transfusion community include the trend towards lower red cell stock holdings and the changing trends in weapon use and tactics. A standardized approach to transfusion data collection is required to support future planning. The transfusion community is encouraged to plan for MCEs, contribute to ‘after action reviews’ and work together for safe and sustainable transfusion support.

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“…In addition toRamsey, 2017, outcomes from these mass casualty events are detailed in Karen Quillen, "Blood Use After the Boston Marathon Bombing April 2013," presented at AABB Annual Meeting, San Diego, Calif., October 7, 2017; and Pierre Tiberghien, "Mass Casualty Events: Blood Bank and Transfusion Service Perspective-The November 13th, 2015 Paris Attacks," presented at AABB Annual Meeting, San Diego, Calif., October 7, 2017.…”

mentioning

confidence: 99%

Toward Resiliency in the Joint Blood Supply Chain

Thomas¹,

Anania²,

DeCicco³

et al. 2018

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Blood component transfusions in mass casualty events

Abstract: Blood component use in MCEs correlated with numbers of patients admitted or receiving massive transfusion. More current data are needed to better reflect emerging trauma care practices and refine predictive models of transfusion needs.

Cited by 16 publications

References 36 publications

Critical developments of 2018: A review of the literature from selected topics in transfusion. A committee report from the AABB's Clinical Transfusion Medicine Committee

Critical developments of 2018: A review of the literature from selected topics in transfusion. A committee report from the AABB's Clinical Transfusion Medicine Committee

Transfusion emergency preparedness for mass casualty events

Toward Resiliency in the Joint Blood Supply Chain

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