Critical developments of 2018: A review of the literature from selected topics in transfusion. A committee report from the AABB's Clinical Transfusion Medicine Committee

Abstract

RESULTS:The following topics are covered: "big data"and "omics" studies, emerging infections and testing, platelet transfusion and pathogen reduction, transfusion therapy and coagulation, transfusion approach to hemorrhagic shock and mass casualties, therapeutic apheresis, and chimeric antigen receptor T-cell therapy. CONCLUSION:This synopsis may be a useful educational tool. ABBREVIATIONS: ARC = American Red Cross; CAR = chimeric antigen receptor; CJD = Creutzfeldt-Jakob disease; CRS = cytokine release syndrome; DENV = Dengue virus; FDA = US Food and Drug Administration; IgM = immunoglobulin M; IRIS = immune reconstitution inflammatory syndrome; NAT = nucleic acid testing; NTZ = natalizumab; NTZ-PML = NTZ-associated PML; PAS = platelets in additive solution; PCR = polymerase chain reaction; PML = progressive multifocal leukoencephalopathy; PR = pathogen reduction; RCT = randomized controlled trial; TMA = transcriptionmediated amplification; TPE = therapeutic plasma exchange; TTP = thrombotic thrombocytopenic purpura; ZIKV = Zika virus. From the