Blood Compatibility in Cardiopulmonary Bypass

Courtney, J. M.; Irvine, Linda; Gaylor, J.D.S.; Forbes, C.D.; Taylor, KM

doi:10.1007/978-1-4471-1847-3_2

Cited by 7 publications

(2 citation statements)

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“…Contact activation has been studied in hemodialysis (2) and cardiopulmo-nary bypass (2,4) and can be monitored by measurement of Factor XII-like activity. Contact activation has been studied in hemodialysis (2) and cardiopulmo-nary bypass (2,4) and can be monitored by measurement of Factor XII-like activity.…”

Section: Selection Of Representative Parametersmentioning

confidence: 99%

“…The fibrinolytic system is activated during hemodialysis (2) or cardiopulmonary bypass (2,4), and this activity can be determined by measurement of crosslinked fibrin degradation products. The fibrinolytic system is activated during hemodialysis (2) or cardiopulmonary bypass (2,4), and this activity can be determined by measurement of crosslinked fibrin degradation products.…”

Section: Selection Of Representative Parametersmentioning

confidence: 99%

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Monitoring of the Blood Response in Blood Purification

et al. 1993

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A principal objective of monitoring the blood response in procedures such as hemodialysis and cardiopulmonary bypass is to achieve an enhanced understanding of the relationship between blood component alterations and the biomaterials employed. The aim in a study of blood-biomaterial interactions of deriving a correlation between a characteristic of the biomaterial and a representative parameter of the blood response can be influenced in a clinical situation by antithrombotic agents, multimaterial contact, device utilization, blood condition, drug therapy, and the nature of the application. The selection of parame-ters representative of the blood response may require a compromise between the advantages of multiparameter assessment and the benefit of measuring a single parameter by a consistent methodology. Representative parameters are protein adsorption, platelet reactions, intrinsic coagulation and the contact activation phase, fibrinolysis, leukocyte alterations, and complement activation. Assessment during clinical application can be approached by consideration of blood response patterns.

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Section: Selection Of Representative Parametersmentioning

confidence: 99%

Section: Selection Of Representative Parametersmentioning

confidence: 99%

Monitoring of the Blood Response in Blood Purification

et al. 1993

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Effects of Heparin Coating of Cardiopulmonary Bypass Circuits on In Vitro Oxygen Free Radical Production During Coronary Bypass Surgery

et al. 1996

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During cardiopulmonary bypass (CPB) oxygen free radicals (OFR) are formed, which can mediate reactions damaging tissue components. Blood contact with artificial surfaces during CPB leads to an activation of leukocytes, which are one of the sources of the OFR. Heparin coating of the CPB circuit reduces granulocyte activation. In the present study, the heparin-coated circuits with noncoated cardiotomy reservoirs (Group HC) were compared with noncoated, otherwise similar CPB sets (Group C). In each group, 8 patients were operated on for coronary revascularization. The release of granulocyte granule proteins myeloperoxidase (MPO) and lactoferrin (LF) was evaluated. Production of OFR in the whole blood and in the granulocyte suspension were measured by chemiluminescence (CL). In both groups the whole blood CL declined during CPB. The whole blood CL induced by serum-opsonized zymosan, when enhanced by luminol, was significantly lower in Group HC at 45 min after CPB start (68 +/- 6% of initial values in Group HC vs. 87 +/- 6% in Group C, mean +/- SEM) and 30 min after protaminization (54 +/- 6% of initial values in Group HC vs. 72 +/- 6% in Group C, mean +/- SEM), and CL was significantly higher in Group HC at CPB end (83 +/- 5% of initial values in Group HC vs. 67 +/- 5% in Group C, mean +/- SEM) when enhanced by lucigenin. CL of isolated granulocytes showed no significant differences between the groups. Release of MPO at CPB end and of LF 45 min after start of CPB and at CPB end were significantly lower in the heparin-coated CPB circuits.

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