Blood coagulation alterations over the first 10 days after severe burn injury

Barbier, Jeanne; Viana, Marina Verçoza; Pantet, Olivier; Alberio, Lorenzo; Berger, Mette M.

doi:10.1016/j.burnso.2021.08.075

Cited by 2 publications

(3 citation statements)

References 31 publications

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“…Being the main inhibitor of plasminogen activators, PAI-1 plays a central role in the regulation of the fibrinolytic system [52]. Its increased levels until day 10 post -burn explain, among other factors, the procoagulant state of the patients with a severe burn that has been described and documented in many articles and monographs [14,53]. In our study, we could not find any statistically significant correlation between the PAI-1 serum levels and TBSA.…”

Section: Discussioncontrasting

confidence: 65%

Serum Plasminogen Activator Inhibitor-1, α 1-Acid Glycoprotein, C-Reactive Protein, and Platelet Factor 4 Levels—Promising Molecules That Can Complete the “Puzzle” of the Biochemical Milieu in Severe Burns: Preliminary Results of a Cohort Prospective Study

Badoiu,

Enescu,

Tatar

et al. 2024

JCM

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Background: Burns represent a serious health problem, associated with multiple-organ failure, prolonged hospitalization, septic complications, and increased rate of mortality. The main aim of our study was to evaluate the levels of various circulating molecules in children with severe burns (more than 25% TBSA), in three different moments: 48 h, day 10, and day 21 post-burn. Materials and Methods: This study included 32 children with burns produced by flame, hot liquid, and electric arc and 21 controls. Serum plasminogen activator inhibitor-1 (PAI-1), α 1-acid glycoprotein (AGP), C-reactive protein (CRP), and platelet factor 4 (PF4) were detected using the Multiplex technique. Several parameters, such as fibrinogen, leucocyte count, thrombocyte count, triiodothyronine, thyroxine, and thyroid-stimulating hormone were also determined for each patient during hospitalization. Results: Significant statistical differences were obtained for CRP, AGP, and PF4 compared to the control group, in different moments of measurements. Negative correlations between CRP, AGP, and PF4 serum levels and burned body surface, and also the hospitalization period, were observed. Discussions: CRP levels increased in the first 10 days after burn trauma and then decreased after day 21. Serum PAI-1 levels were higher immediately after the burn and started decreasing only after day 10 post-burn. AGP had elevated levels 48 h after the burn, then decreased at 7–10 days afterwards, and once again increased levels after 21 days. PF4 serum levels increased after day 10 since the burning event. Conclusions: Serum CRP, AGP, PAI-1, and PF4 seem to be promising molecules in monitoring patients with a burn within the first 21 days.

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Section: Discussioncontrasting

confidence: 65%

Serum Plasminogen Activator Inhibitor-1, α 1-Acid Glycoprotein, C-Reactive Protein, and Platelet Factor 4 Levels—Promising Molecules That Can Complete the “Puzzle” of the Biochemical Milieu in Severe Burns: Preliminary Results of a Cohort Prospective Study

Badoiu,

Enescu,

Tatar

et al. 2024

JCM

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“…These results are in concordance with previous studies. Barbier et al’s study, including 167 patients with severe burns, also showed that during the first 72 h, thrombocytopenia increased with the burned surface and had a nadir by day 4 [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, any element promoting bleeding, including thrombocytopenia, should be reduced to a minimum before burn surgery [ 23 ]. Unfortunately for surgical interventions, the literature reports that the platelet nadir level is on day 3 [ 28 ] or day 4 [ 33 ], which corresponds to the time when grafting procedures should start.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic and Prognostic Value of Thrombocytopenia in Severe Burn Injuries

Bordeanu-Diaconescu,

Grosu-Bularda,

Frunza

et al. 2024

Diagnostics

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Background and objectives: Burn injuries are the most severe type of trauma, with complex biological consequences associated with high rates of morbidity and mortality. Prompt recognition and management of burn-related complications are imperative for improving the vital and functional prognosis of the patient. Changes in biological parameters can be essential determinants in the prognosis of the burned patient. Thrombocytopenia in critically ill patients is linked to an elevated risk of mortality. We sought to investigate the significance of thrombocytopenia in severely burned patients while considering the limited available data in the literature. Materials and methods: A two-year retrospective study was conducted on 90 patients with severe burns admitted to our Burn Centre. Demographic data, burn lesion characteristics, and daily total blood counts, including platelet assessment, complications, and mortality, were recorded and analyzed. Results: Patients with extensive burns in our study had a poor prognosis based on their Abbreviated Burn Severity Index score (ABSI), age, percentage of total body surface area (TBSA) burned, presence of third-degree burns, and inhalation injuries. Regardless of the moment, patients with thrombocytopenia in our study died significantly more frequently. Compared with the survivors, the platelet count was significantly lower at any given time in the non-survivors group. Significant statistical associations between thrombocytopenia and ABSI score, burn surface area, presence of third-degree burns, and inhalation injuries were identified at different timeframes post-burn injury. Sepsis was encountered in one-third of the patients. Thrombocytopenia was more frequent in patients with sepsis who did not survive compared to survivors and did not normalize until the time of death. Conclusions: Thrombocytopenia represents an early indicator of severe complications and outcome predictor in severely burned patients. It is correlated with recognized negative prognostic factors and also with sepsis occurrence. Future research efforts should focus on refining early detection parameters and interventions to improve the prognosis of burn patients.

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Blood coagulation alterations over the first 10 days after severe burn injury

Cited by 2 publications

References 31 publications

Serum Plasminogen Activator Inhibitor-1, α 1-Acid Glycoprotein, C-Reactive Protein, and Platelet Factor 4 Levels—Promising Molecules That Can Complete the “Puzzle” of the Biochemical Milieu in Severe Burns: Preliminary Results of a Cohort Prospective Study

Serum Plasminogen Activator Inhibitor-1, α 1-Acid Glycoprotein, C-Reactive Protein, and Platelet Factor 4 Levels—Promising Molecules That Can Complete the “Puzzle” of the Biochemical Milieu in Severe Burns: Preliminary Results of a Cohort Prospective Study

Diagnostic and Prognostic Value of Thrombocytopenia in Severe Burn Injuries

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