Blood clot initiation by mesoporous silica nanoparticles: dependence on pore size or particle size?

Chen, Zihao; Li, Fan; Liu, Changjun; Guan, Jun; Hu, Xiao; Du, Ge; Yao, Xinpei; Wu, Jimin; Tian, Faming

doi:10.1039/c6tb01946c

Cited by 76 publications

(57 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, more pseudopod platelets were presented on the surface of 2%CDDs, the quantity of pseudopod platelets was further increased in the 2%CDDs‐30%TBA, 2%CDDs‐60%TBA, and 2%CDDs‐100%TBA groups, indicating their outstanding ability to induce platelet adhesion and activation, which proved their higher hemostatic efficiency. [ 27 ] Surface negative charge of DB in CDDs‐TBA could activate intrinsic coagulation pathway to enhance platelet adhesion and aggregation. Moreover, the hierarchical porous structure of DB and chitosan matrix could concentrate functional proteins in plasma, thus further promote platelet adhesion and activation.…”

Section: Resultsmentioning

confidence: 99%

Chitosan/Diatom‐Biosilica Aerogel with Controlled Porous Structure for Rapid Hemostasis

Sun

Zhang

et al. 2020

Adv Healthcare Materials

View full text Add to dashboard Cite

Uncontrolled hemorrhage is the main reason of possible preventable death after accidental injury. It is necessary to develop a hemostatic agent with rapid hemostatic performance and good biocompatibility. In this study, a chitosan/diatom-biosilica-based aerogel is developed using dopamine as cross-linker by simple alkaline precipitation and tert-butyl alcohol replacement. The chitosan/diatom-biosilica aerogel exhibits favorable biocompatibility and multiscale hierarchical porous structure (from nanometer to micrometer), which can be controlled by the concentration of tert-butyl alcohol. The displacement of tert-butyl alcohol can keep the porosity of diatom-biosilica in aerogel and give it large surface with efficient water absorption ratio. 30% tert-butyl alcohol replacement of aerogel possesses the largest surface area (74.441 m 2 g −1), water absorption capacity (316.83 ± 2.04%), and excellent hemostatic performance in vitro blood coagulation (≈70 s). Furthermore, this aerogel exhibits the shortest clotting time and lowest blood loss in rat hemorrhage model. The strong interface effect between aerogel and blood is able to promote erythrocytes aggregation, platelets adhesion, and activation, as well as, activate the intrinsic coagulation pathway to accelerate blood coagulation. All the above results demonstrate that chitosan/diatom-biosilica aerogel has great potential to be a safe and rapid hemostatic material.

show abstract

Section: Resultsmentioning

confidence: 99%

Chitosan/Diatom‐Biosilica Aerogel with Controlled Porous Structure for Rapid Hemostasis

Sun

Zhang

et al. 2020

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…Clinical Standard Coagulation Tests : The coagulation tests including aPTT, PT, TT, and Fbg were conducted using an automatic coagulation analyzer (CA‐7000, Sysmex medical electronics (Shanghai) Co., Ltd.) according to the procedure published previously . For PT, TT, and Fbg measurement, 500 µL of PPP and sample (5 mg mL −1 ) were mixed and incubated at 37 °C for 3 min, then centrifugated and measured by automatic coagulation analyzer.…”

Section: Methodsmentioning

confidence: 99%

“…Early intervention to halt bleeding during the first few minutes after injury is critical for improving the chances of survival. Several topical hemostats based on organic polymers and inorganic micro‐/nanometer materials have been developed . Since the U.S. Food and Drug Administration (FDA) approved QuikClot, a zeolite‐based externally applied hemostat in 2002, there has been considerable interest in natural nanoclay minerals for the management of massive hemorrhage–especially for battlefield trauma–owing to their high absorption and biological inertness .…”

Section: Introductionmentioning

confidence: 99%

Emerging Nanoclay Composite for Effective Hemostasis

Long

Zhang

Huang

et al. 2017

Adv Funct Materials

128

View full text Add to dashboard Cite

Uncontrolled bleeding following trauma is associated with a high risk of death. Here, an emerging kaolinite nanoclay composite (iron oxide-kaolinite, α-Fe 2 O 3 -kaolin KAc ) is developed, based on the natural hemostat hematitum used in traditional Chinese medicine to effectively control hemorrhage. α-Fe 2 O 3 -kaolin KAc stops bleeding in ≈183 ± 16 s and exhibits higher hemostatic activity than the related compounds FeOOH-kaolin KAc (298 ± 14 s), γ-Fe 2 O 3 -kaolin KAc (212 ± 11 s), and Fe 3 O 4 -kaolin KAc (218 ± 15 s). This rapid effect is attributed to efficient absorption of the fluid in blood, activation of blood platelets, and induction of the coagulation cascade by kaolinite and the aggregation of red blood cells induced by α-Fe 2 O 3 . α-Fe 2 O 3 -kaolin KAc shows slight hemolysis (<0.11%) as compared to kaolinite (30%), which accelerates wound healing. The biocompatibility, hemostatic activity, and low cost of α-Fe 2 O 3 -kaolin KAc make it a safe and effective agent for preventing massive blood loss after traumatic injury.

show abstract

“…It is worth noting that KEM 1.5 showed the best hemostasis capability among all the NEMs, which reaches the 'standard of care' level for commercial products (ClG and CoG) in the three in vivo bleeding models (Fig. 4a), varied from those reported nanoclay-containing composites 13,14,16,19 , inorganic nanoparticles 44 and other hemostatic materials 5,6,45,46 that involve poor mechanical strength and inflammation and thrombosis risk due to fine particles or the particles exfoliation from incompact structure (Supplementary Table 2).…”

Section: Resultsmentioning

confidence: 87%

Robust hemostatic bandages based on nanoclay electrospun membranes

Cui

Huang

et al. 2021

Nat Commun

View full text Add to dashboard Cite

Death from acute hemorrhage is a major problem in military conflicts, traffic accidents, and surgical procedures, et al. Achieving rapid effective hemostasis for pre-hospital care is essential to save lives in massive bleeding. An ideal hemostasis material should have those features such as safe, efficient, convenient, economical, which remains challenging and most of them cannot be achieved at the same time. In this work, we report a rapid effective nanoclay-based hemostatic membranes with nanoclay particles incorporate into polyvinylpyrrolidone (PVP) electrospun fibers. The nanoclay electrospun membrane (NEM) with 60 wt% kaolinite (KEM1.5) shows better and faster hemostatic performance in vitro and in vivo with good biocompatibility compared with most other NEMs and clay-based hemostats, benefiting from its enriched hemostatic functional sites, robust fluffy framework, and hydrophilic surface. The robust hemostatic bandages based on nanoclay electrospun membrane is an effective candidate hemostat in practical application.

show abstract

Blood clot initiation by mesoporous silica nanoparticles: dependence on pore size or particle size?

Abstract: The hemostatic efficiency of mesoporous silica nanoparticles depends on pore size more than particle size, and biocompatibility is more related to particle size.

Cited by 76 publications

References 32 publications

Chitosan/Diatom‐Biosilica Aerogel with Controlled Porous Structure for Rapid Hemostasis

Chitosan/Diatom‐Biosilica Aerogel with Controlled Porous Structure for Rapid Hemostasis

Emerging Nanoclay Composite for Effective Hemostasis

Robust hemostatic bandages based on nanoclay electrospun membranes

Contact Info

Product

Resources

About