Blood Clearance and Tissue Distribution of PEGylated and Non-PEGylated Gold Nanorods After Intravenous Administration in Rats

Lankveld, D. P. K.; Rayavarapu, R.G.; Krystek, Petra; Oomen, Agnes G.; Verharen, Hennie W.; Leeuwen, Ton G. van; Jong, Wim H. de; Manohar, Srirang

doi:10.2217/nnm.10.122

Cited by 141 publications

(114 citation statements)

References 45 publications

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“…42,43 Regardless of the NP delivery mechanisms used, uptake by the reticuloendothelial system (RES), particularly the liver, spleen, and kidney, prevent up to 90% of systemically injected NPs from successfully reaching the tumor. [44][45][46][47][48][49] New approaches in NP conjugation technology are needed to optimize NP delivery to the tumor. Further, to our knowledge, many studies using NP-enabled NIR photothermal therapy have not included a rigorous histological analysis of treated tumors, thus creating a knowledge gap of the effect of photothermal therapy at the cellular level.…”

Section: Green Et Almentioning

confidence: 99%

A histological evaluation and in vivo assessment of intratumoral near infrared photothermal nanotherapy-induced tumor regression

Green¹,

Crockett²,

Martyshkin³

et al. 2014

IJN

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Purpose Nanoparticle (NP)-enabled near infrared (NIR) photothermal therapy has realized limited success in in vivo studies as a potential localized cancer therapy. This is primarily due to a lack of successful methods that can prevent NP uptake by the reticuloendothelial system, especially the liver and kidney, and deliver sufficient quantities of intravenously injected NPs to the tumor site. Histological evaluation of photothermal therapy-induced tumor regression is also neglected in the current literature. This report demonstrates and histologically evaluates the in vivo potential of NIR photothermal therapy by circumventing the challenges of intravenous NP delivery and tumor targeting found in other photothermal therapy studies. Methods Subcutaneous Cal 27 squamous cell carcinoma xenografts received photothermal nanotherapy treatments, radial injections of polyethylene glycol (PEG)-ylated gold nanorods and one NIR 785 nm laser irradiation for 10 minutes at 9.5 W/cm 2 . Tumor response was measured for 10–15 days, gross changes in tumor size were evaluated, and the remaining tumors or scar tissues were excised and histologically analyzed. Results The single treatment of intratumoral nanorod injections followed by a 10 minute NIR laser treatment also known as photothermal nanotherapy, resulted in ~100% tumor regression in ~90% of treated tumors, which was statistically significant in a comparison to the average of all three control groups over time ( P <0.01). Conclusion Photothermal nanotherapy, or intratumoral nanorod injections followed by NIR laser irradiation of tumors and tumor margins, demonstrate the potential of NIR photothermal therapy as a viable localized treatment approach for primary and early stage tumors, and prevents NP uptake by the reticuloendothelial system.

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Section: Green Et Almentioning

confidence: 99%

A histological evaluation and in vivo assessment of intratumoral near infrared photothermal nanotherapy-induced tumor regression

Green¹,

Crockett²,

Martyshkin³

et al. 2014

IJN

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“…11,27 One type of gold nanoparticle with a strong tunable plasmon resonance in the near-infrared spectral range is a gold nanorod (GNR). 4,28,29 After administration into the animal, GNRs get distributed inside the body according to their modified affinity, resulting in the enhancement of optical contrast of the targeted tissues. 26,30 GNRs were also used as OA contrast agents for quantitative flow analysis in biological tissue 31 and to investigate the kinetics of drug delivery compounds.…”

Section: Introductionmentioning

confidence: 99%

Three-dimensional optoacoustic imaging as a new noninvasive technique to study long-term biodistribution of optical contrast agents in small animal models

Ermilov

Liopo

et al. 2012

J. Biomed. Opt.

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“…Coating with polyethylene glycol (PEG) has been shown to enable escape from the MPS for a prolonged period of time, thereby increasing the half-life in blood. 86,87 Dobrovolskaia et al 60 reported recently that the molecular weight of PEG coating affected the total amount of protein binding. However, the types of proteins forming the protein corona were not influenced by …”

mentioning

confidence: 99%

A comparison of immunotoxic effects of nanomedicinal products with regulatory immunotoxicity testing requirements

Giannakou¹,

Park²,

Jong³

et al. 2016

IJN

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Nanomaterials (NMs) are attractive for biomedical and pharmaceutical applications because of their unique physicochemical and biological properties. A major application area of NMs is drug delivery. Many nanomedicinal products (NMPs) currently on the market or in clinical trials are most often based on liposomal products or polymer conjugates. NMPs can be designed to target specific tissues, eg, tumors. In virtually all cases, NMPs will eventually reach the immune system. It has been shown that most NMs end up in organs of the mononuclear phagocytic system, notably liver and spleen. Adverse immune effects, including allergy, hypersensitivity, and immunosuppression, have been reported after NMP administration. Interactions of NMPs with the immune system may therefore constitute important side effects. Currently, no regulatory documents are specifically dedicated to evaluate the immunotoxicity of NMs or NMPs. Their immunotoxicity assessment is performed based on existing guidelines for conventional substances or medicinal products. Due to the unique properties of NMPs when compared with conventional medicinal products, it is uncertain whether the currently prescribed set of tests provides sufficient information for an adequate evaluation of potential immunotoxicity of NMPs. The aim of this study was therefore, to compare the current regulatory immunotoxicity testing requirements with the accumulating knowledge on immunotoxic effects of NMPs in order to identify potential gaps in the safety assessment. This comparison showed that immunotoxic effects, such as complement activation-related pseudoallergy, myelosuppression, inflammasome activation, and hypersensitivity, are not readily detected by using current testing guidelines. Immunotoxicity of NMPs would be more accurately evaluated by an expanded testing strategy that is equipped to stratify applicable testing for the various types of NMPs.

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Blood Clearance and Tissue Distribution of PEGylated and Non-PEGylated Gold Nanorods After Intravenous Administration in Rats

Cited by 141 publications

References 45 publications

A histological evaluation and in vivo assessment of intratumoral near infrared photothermal nanotherapy-induced tumor regression

A histological evaluation and in vivo assessment of intratumoral near infrared photothermal nanotherapy-induced tumor regression

Three-dimensional optoacoustic imaging as a new noninvasive technique to study long-term biodistribution of optical contrast agents in small animal models

A comparison of immunotoxic effects of nanomedicinal products with regulatory immunotoxicity testing requirements

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