Three-dimensional optoacoustic imaging as a new noninvasive technique to study long-term biodistribution of optical contrast agents in small animal models

Su, Richard; Ermilov, Sergey A.; Liopo, Anton V.; Oraevsky, Alexander A.

doi:10.1117/1.jbo.17.10.101506

Cited by 42 publications

(46 citation statements)

References 56 publications

(80 reference statements)

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“…The result is used as the base formula to analyze the heat dissipation of MNPs accumulated over the bursting duration of an AMF in time-domain configuration, and to justify the timevarying heat dissipation of MNPs over individual cycles of a frequency-chirped AMF. Notice that the relation between a heat-dissipation and the initial acoustic pressure of thermally induced acoustic wave has been established, [13][14][15][16][17] under the condition of thermal and acoustic confinement. Therefore, an estimation of the heat dissipation of MNPs when exposed to a time-or frequency-domain AMF of practical utility could indicate the feasibility of magnetothermoacoustics.…”

Section: Theorymentioning

confidence: 99%

Magnetothermoacoustics from magnetic nanoparticles by short bursting or frequency chirped alternating magnetic field: A theoretical feasibility analysis

et al. 2013

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Purpose:To propose an alternative method of thermoacoustic wave generation based on heating of magnetic nanoparticles (MNPs) using alternating magnetic field (AMF). Methods: The feasibility of thermoacoustic wave generation from MNPs by applying a short-burst of AMF or a frequency-modulated AMF is theoretically analyzed. As the relaxation of MNPs is strongly dependent upon the amplitude and frequency of AMF, either an amplitude modulated, fixed frequency AMF (termed time-domain AMF) or a frequency modulated, constant amplitude AMF (termed frequency-domain AMF) will result in time-varying heat dissipation from MNPs, which has the potential to generate thermoacoustic waves. Following Rosensweig's model of specific power loss of MNPs in a steady-state AMF, the time-resolved heat dissipations of MNPs of superparamagnetic size when exposed to a short bursting of AMF and/or to a linearly frequency chirped AMF are derived, and the resulted acoustic propagation is presented. Based on experimentally measured temperaturerise characteristics of a superparamagnetic iron-oxide nanoparticle (SPION) matrix in a steady-state AMF of various frequencies, the heat dissipations of the SPION under time-domain and frequencydomain AMF configurations that could have practical utility for thermoacoustic wave generation are estimated. Results:The initial rates of the temperature-rise of the SPION matrix were measured at an ironweight concentration of 0.8 mg/ml and an AMF frequency of 88.8 kHz to 1.105 MHz. The measured initial rates of temperature-rise were modeled by Rosensweig's theory, and projected to 10 MHz AMF frequency, at which a 1 μs bursting corresponding to a 1.55 mm axial resolution of acoustic detection could contain 10 complete cycles of AMF oscillation and the power dissipation is approximately 84 times of that at 1 MHz. Exposing the SPION matrix to a 1 μs bursting of AMF at 10 MHz frequency and 100 Oe field intensity would produce a volumetric heat dissipation of 7.7 μJ/cm 3 over the microsecond duration of the AMF burst. If the SPION matrix is exposed to a 1 ms long AMF train at 100 Oe field intensity that chirps linearly from 1 to 10 MHz, the volumetric heat dissipation produced over each 2π phase change of the AMF oscillation is estimated to increase from 0.15 to 1.1 μJ/cm 3 within the millisecond duration of the chirping of AMF. Conclusions: The heat dissipations upon SPION (∼1 mg/ml iron-weight concentration) by a 1 μs bursting of 100 Oe AMF at 10 MHz and a 1 ms train of 100 Oe AMF that chirps linearly from 1 to 10 MHz were estimated to determine the potential of thermal-acoustic wave generation. Although thermoacoustic wave generation from MNPs by time-or frequency-domain AMF applications is predicted, the experimental generation of such a wave remains challenging. © 2013 American Association of Physicists in Medicine. [http://dx

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Section: Theorymentioning

confidence: 99%

Magnetothermoacoustics from magnetic nanoparticles by short bursting or frequency chirped alternating magnetic field: A theoretical feasibility analysis

et al. 2013

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“…59,60 Previously, we described general strategy for stabilization of GNR with thiol-terminal PEG, which displaces the original bilayer of surfactant CTAB to provide reduced potential connection of GNR with the tube internal wall. 61,62 As a result, we got two types of pegylated GNR with different maxima of localized surface plasmon resonance (LSPR): one at the wavelength of 757 nm and the other at 1064 nm, which correspond to the two short-pulse lasers, the Alexandrite laser (757 nm), and the Nd:YAG laser (1064 nm).…”

Section: Gold Nanorodsmentioning

confidence: 99%

“…4,[62][63][64][65] Laser output consisted of Alexandrite laser (757 nm, 50 ns∕pulse) and Nd:YAG (1064 nm, 9 ns∕pulse), which was manufactured as a single unit with coaxial output beams (Quanta Systems, Solbiate Olona, Italy). 62 OA tomography was performed using the imaging module of LOIS-3-D, as shown in Fig. 2.…”

Section: Optoacoustic Imaging Systemmentioning

confidence: 99%

“…2). 62,63 The pulsed laser energy was about 6.5 mJ out of each of the four fiberoptic illuminators, which corresponded to the total effective optical fluence of 2.5 mJ∕cm 2 .The system has low noise equivalent pressure of 2 Pa without averaging, 64 which permits reliable visualization of the OA contrast generated by variation of the tissue optical absorption of 0.12 cm −1 with 4-pulse averaging, making the total image acquisition time 2 min. The phantom consisted of four garolite rods for support, angled target tubes (tubes with GNR and nickel sulfate), and a layer of skin of 2.5 cm height creating a rectangular shell centered around the section of the tubes, where the focus of the arc would be (see Fig.…”

Section: Optoacoustic Imaging Systemmentioning

confidence: 99%

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Optical clearing of skin enhanced with hyaluronic acid for increased contrast of optoacoustic imaging

Liopo

Tsyboulski

et al. 2016

J. Biomed. Opt

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Abstract. Enhanced delivery of optical clearing agents (OCA) through skin may improve sensitivity of optical and optoacoustic (OA) methods of imaging, sensing, and monitoring. This report describes a two-step method for enhancement of light penetration through skin. Here, we demonstrate that topical application of hyaluronic acid (HA) improves skin penetration of hydrophilic and lipophilic OCA and thus enhances their performance. We examined the OC effect of 100% polyethylene and polypropylene glycols (PPGs) and their mixture after pretreatment by HA, and demonstrated significant increase in efficiency of light penetration through skin. Increased light transmission resulted in a significant increase of OA image contrast in vitro. Topical pretreatment of skin for about 30 min with 0.5% HA in aqueous solution offers effective delivery of low molecular weight OCA such as a mixture of PPG-425 and polyethylene glycol (PEG)-400. The developed approach of pretreatment by HA prior to application of clearing agents (PEG and PPG) resulted in a ∼47-fold increase in transmission of red and near-infrared light and significantly enhanced contrast of OA images.

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“…Depending on the laser pulse repetition rate, the data acquisition time required for one full 3D image can range from several minutes [23] to about half hour [22]. This is extremely long compared to real-time 3D imaging devices that use large piezoelectric arrays [24,25]. However, it is not always necessary to image a large volume if there exists a defined region of interest within an extended object.…”

Section: Introductionmentioning

confidence: 99%

Hybrid photoacoustic and ultrasound section imaging with optical ultrasound detection

Nuster

Schmitner

Wurzinger

et al. 2013

Journal of Biophotonics

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Journal of BIOPHOTONICSA setup is proposed that provides perfectly co-registered photoacoustic (PA) and ultrasound (US) section images. Photoacoustic and ultrasound backscatter signals are generated by laser pulses coming from the same laser system, the latter by absorption of some of the laser energy on an optically absorbing target near the imaged object. By measuring both signals with the same optical detector, which is focused into the selected section by use of a cylindrical acoustic mirror, the information for both images is acquired simultaneously. Co-registered PA and US images are obtained after applying the inverse Radon transform to the data, which are gathered while rotating the object relative to the detector. Phantom experiments demonstrate a resolution of 1.1 mm between the sections of both imaging modalities and a inplane resolution of about 60 mm and 120 mm for the US and PA modes, respectively. The complementary contrast mechanisms of the two modalities are shown by images of a zebrafish.Result of the dual-modality section imaging experiment on a zebrafish. Scale bar: 1 mm. The first row shows the photoacoustic (PA) and the laser ultrasound (LUS) section image. The second row shows the fusion image (FI) and the histological section.

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Three-dimensional optoacoustic imaging as a new noninvasive technique to study long-term biodistribution of optical contrast agents in small animal models

Cited by 42 publications

References 56 publications

Magnetothermoacoustics from magnetic nanoparticles by short bursting or frequency chirped alternating magnetic field: A theoretical feasibility analysis

Magnetothermoacoustics from magnetic nanoparticles by short bursting or frequency chirped alternating magnetic field: A theoretical feasibility analysis

Optical clearing of skin enhanced with hyaluronic acid for increased contrast of optoacoustic imaging

Hybrid photoacoustic and ultrasound section imaging with optical ultrasound detection

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