Blood Chimerism in a Pair of Twins

Booth, P. B.; Plaut, Gertrude; James, Justin; Ikin, Elizabeth W.; Moores, Phyllis; Sanger, Ruth; Race, R. R.

doi:10.1136/bmj.1.5033.1456

Cited by 101 publications

(32 citation statements)

References 9 publications

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“…Few male subjects in this study demonstrated cellular chimerism due to the presence of neutrophilic drumsticks. This finding was reported earlier by Davidson implying that the cells ancestors can be grafted in initial stages of embryogenesis due to the influence of female sex hormones and so affect cellular lineages [13]. He found drumstick as a predominant feature in identification of cytological sex [6].…”

Section: Investigationssupporting

confidence: 59%

Sex Chromatin in Peripheral Blood Neutrophils and Sex Determination

Miknienė¹,

Ivanauskaitė²

2018

CRCM

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The objective of this paper is to review in what forms sex chromatin can appear in peripheral blood neutrophils and how sex determination can be done using sex chromatin appendages. Sex chromatin is an approximately 1 micron clump of chromatin seen usually at the periphery of female nuclei in certain tissues and called "Barr body" and as a drumstick in polymor phonuclear neutrophils nuclei in the blood smears. Sex chromatin is derived from one of the two X chromosomes in the female which replicates its deoxyribonucleic acid much later than the other and is thus positively heteropyknotic. In 1954, Davidson and Smith were the first to identify and report the presence of neutrophil drumsticks and nonspecific appendages and their differences in sexes. The inactive X chromosome in neutrophils appears in one of the five forms: drumsticks, racquet forms, sessile nodules, small clubs and minor lobes. Only drumstick appendage is sex-specific and considered for sex diagnosis. For sex determination, drumsticks are significantly higher in females than in males (p < 0.001).

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Section: Investigationssupporting

confidence: 59%

Sex Chromatin in Peripheral Blood Neutrophils and Sex Determination

Miknienė¹,

Ivanauskaitė²

2018

CRCM

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“…However, there are now sufficient reasons for concluding that this is not so. Human blood-group chimeras have been described in which one twin of blood group O also has a small quantity of cells of blood group A [23,3,28]. Such individuals do not have antibody directed against blood group A in their circulation.…”

Section: Discussionmentioning

confidence: 99%

Tolerance-Mediated Inheritance of Immune Responsiveness

Cinader¹,

Koh²,

Naylor³

1969

Int Arch Allergy Immunol

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“…In each test approximately 50°/o of the cells were agglutinated. Two distinct red cell populations were separated by us ing anti-A serum [2], and on a later occasion with incomplete anti-D se rum followed by antiglobulin reagent. The groups of the separated cells were as follows: (1) Lewis antigens and secretions.…”

Section: Resultsmentioning

confidence: 99%

Blood Group and Tissue Mosaicism in a Natal Indian Woman

Moores¹

1973

Acta Haematol

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A normal 46, XX karyotype was demonstrated in an Indian woman who has 2 approximately equal populations of red cells and of leucocytes. She also has skin mosaicism. She is a normal female and has borne 4 healthy children. The ABO, Ss, Rh and Fy groups of her 2 red cell populations differed, but both were Le(a+b-) although she is a secretor of B and H substances. The relationship between this and the 7 examples of dispermywith blood group mosaicism reported in the literature is discussed briefly

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Blood Chimerism in a Pair of Twins

Cited by 101 publications

References 9 publications

Sex Chromatin in Peripheral Blood Neutrophils and Sex Determination

Sex Chromatin in Peripheral Blood Neutrophils and Sex Determination

Tolerance-Mediated Inheritance of Immune Responsiveness

Blood Group and Tissue Mosaicism in a Natal Indian Woman

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