Blood cell and plasma protein repellent properties of Star-PEG-modified surfaces

Hoffmann, J.; Groll, Jürgen; Heuts, Jean; Rong, H.; Klee, Doris; Ziemer, Gerhard; Moeller, Martin; Wendel, Hans Peter

doi:10.1163/156856206778366059

Cited by 61 publications

(42 citation statements)

References 18 publications

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“…By testing three different types of polymeric particles (PLA, PNIPAM-NH 2 and PEG) with different biocompatibilities [60, 61], our studies show that there is a very good linear relationship between chemiluminescence intensities and histological inflammatory measurements. As expected, the stronger inflammatory reactions are accompanied with higher L-012-dependent chemiluminescence intensities.…”

Section: Discussionmentioning

confidence: 99%

Noninvasive assessment of localized inflammatory responses

Zhou

Tsai

Hong

et al. 2012

Free Radical Biology and Medicine

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Inflammatory diseases are associated with the accumulation of activated inflammatory cells, particularly polymorphonuclear neutrophils (PMN), which release reactive oxygen species (ROS) to eradicate foreign bodies and microorganisms. To assess the location and extent of localized inflammatory responses, L-012, a highly-sensitive chemiluminescence probe, was employed to non-invasively monitor the production of ROS. We find that L-012-associated chemiluminescence imaging can be used to identify and to quantify the extent of inflammatory responses. Furthermore, regardless of differences among animal models, there is a good linear relationship between chemiluminescence intensity and PMN numbers surrounding inflamed tissue. Depletion of PMN substantially diminished L-012-associated chemiluminescence in vivo. Finally, L-012-associated chemiluminescence imaging was found to be a powerful tool for assessing implant-mediated inflammatory responses by measuring chemiluminescent intensities at the implantation sites. These results support the use of L-012 for monitoring the kinetics of inflammatory responses in vivo via the detection and quantification of ROS production.

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Section: Discussionmentioning

confidence: 99%

Noninvasive assessment of localized inflammatory responses

Zhou

Tsai

Hong

et al. 2012

Free Radical Biology and Medicine

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“…There are many different ways in which these polymers can be attached to the surface. Also the sort of polymers used can differ from linear to branched, like star-shaped, and from homo-polymers to block-copolymers [34][35][36][37]. These polymers all have in common that they are in most cases hydrophilic.…”

Section: Protein-and Microorganism-repellent Coatingsmentioning

confidence: 99%

New Strategies in the Development of Antimicrobial Coatings: The Example of Increasing Usage of Silver and Silver Nanoparticles

2011

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Bacterial infection from medical devices is a major problem and accounts for an increasing number of deaths as well as high medical costs. Many different strategies have been developed to decrease the incidence of medical device related infection. One way to prevent infection is by modifying the surface of the devices in such a way that no bacterial adhesion can occur. This requires modification of the complete surface with, mostly, hydrophilic polymeric surface coatings. These materials are designed to be non-fouling, meaning that protein adsorption and subsequent microbial adhesion are minimized. Incorporation of antimicrobial agents in the bulk material or as a surface coating has been considered a viable alternative for systemic application of antibiotics. However, the manifestation of more and more multi-drug resistant bacterial strains restrains the use of antibiotics in a preventive strategy. The application of silver nanoparticles on the surface of medical devices has been used to prevent bacterial adhesion and subsequent biofilm formation. The nanoparticles are either deposited directly on the device surface, or applied in a polymeric surface coating. The silver is slowly released from the surface, thereby killing the bacteria present near the surface. In the last decade there has been a surplus of studies applying the concept of silver nanoparticles as an antimicrobial agent on a range of different medical devices. The main problem however is that the exact antimicrobial mechanism of silver remains unclear. Additionally, the antimicrobial efficacy of silver on OPEN ACCESSPolymers 2011, 3 341 medical devices varies to a great extent. Here we will review existing antimicrobial coating strategies and discuss the use of silver or silver nanoparticles on surfaces that are designed to prevent medical device related infections.

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“…Due to the soft consistency of liver parenchyma in some cases, liver tissue protruded through the gaps between the mesh filaments. Previous in vitro studies on cell cultures using the same type of chemical substances described here suggested cell-repellent and anti-adhesive qualities [10,20,21]. This certainly was not demonstrable within this in vivo animal model.…”

Section: Discussionmentioning

confidence: 59%

Biocompatibility of PLGA/sP(EO-stat-PO)-Coated Mesh Surfaces under Constant Shearing Stress

Böhm¹,

Ushakova²,

Alizai³

et al. 2011

Eur Surg Res

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Background: In order to allow inflammatory response modification and ultimately improvement in tissue remodeling, we developed a new surface modification for meshes that will serve as a carrier for other substances. Biocompatibility is tested in an animal model. Methods: The animal model for diaphragmatic hernia repair was established in prior studies. Meshes were surface modified with star-configured PEO (polyethylene oxide)-based molecules [sP(EO-stat-PO)]. An electrospun nanoweb of short-term absorbable PLGA (polylactide-co-glycolide) with integrated sP(EO-stat-PO) molecules was applied onto the modified meshes. This coating also served as aerial sealing of the diaphragm. A final layer of hydrogel was applied to the product. Adhesive properties, defect size and mesh shrinkage were determined, and histological and immunohistochemical investigations performed after 4 months. Results: The mean defect size decreased markedly in both modified mesh groups. Histologically and with regard to apoptosis and proliferation rate, smooth muscle cells, collagen I/III ratio and macrophage count, no statistically significant difference was seen between the 3 mesh groups. Conclusions: In this proof-of-principle investigation, we demonstrate good biocompatibility for this surface-modified mesh compared to a standard polypropylene-based mesh. This new coating represents a promising tool as a carrier for bioactive substances in the near future.

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Blood cell and plasma protein repellent properties of Star-PEG-modified surfaces

Cited by 61 publications

References 18 publications

Noninvasive assessment of localized inflammatory responses

Noninvasive assessment of localized inflammatory responses

New Strategies in the Development of Antimicrobial Coatings: The Example of Increasing Usage of Silver and Silver Nanoparticles

Biocompatibility of PLGA/sP(EO-stat-PO)-Coated Mesh Surfaces under Constant Shearing Stress

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