Blood cell and metabolic profile of Nellore bulls and their correlations with residual feed intake and feed conversion ratio

Santana, Miguel Henrique de Almeida; Rossi, Paulo; Almeida, Rodrigo de; Schuntzemberger, Amanda Massaneira de Souza

doi:10.1590/s1519-99402013000300018

Cited by 12 publications

(6 citation statements)

References 12 publications

(16 reference statements)

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“…The data used in this study are a compilation of 11 different experiments, which were approved by their respective ethic committees (Gomes et al, 2013;Santana et al, 2013). Phenotypic and genotypic information from 720 steers and young Nellore bulls were used in this study.…”

Section: Methodsmentioning

confidence: 99%

Short Communication Genome-wide association with residual body weight gain in Bos indicus cattle

et al. 2015

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ABSTRACT. Weight gain is a key performance trait for beef cattle; however, attention should be given to the production costs for better profitability. Therefore, a feed efficiency trait based on performance can be an interesting approach to improve performance without increasing food costs. To identify candidate genes and genomic regions associated with residual body weight gain (RWG), we conducted a genome-wide association study (GWAS) with 720 Nellore cattle using the GRAMMAR-Gamma association test. We identified 30 significant single nucleotide polymorphisms (SNPs), M.H.A. Santana et al. 5230©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (2): 5229-5233 (2015) especially on chromosomes 2, 8, 12, and 17. Several genes and quantitative train loci (QTLs) present in the regions identified were appointed; we highlight DMRT2 (doublesex and mab-3 related transcription factor 2), IFFO2 (intermediate filament family orphan 2), LNX2 (ligand of numb-protein X 2), MTIF3 (mitochondrial translational initiation factor 3), and TRNAG-CCC (transfer RNA glycine anticodon CCC). The metabolic pathways that can explain part of the phenotypic variation in RWG are related to oxidative stress and muscle control.

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Section: Methodsmentioning

confidence: 99%

Short Communication Genome-wide association with residual body weight gain in Bos indicus cattle

et al. 2015

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“…No statement by the local ethics committee was required because the data used were from other experiments. DNA samples taken from each of the tests had been approved by the respective ethics committees of each study (Gomes et al 2013;Santana et al 2013;Alexandre et al 2015).…”

Section: Ethical Statementmentioning

confidence: 99%

“…The diet was offered twice daily as total mixed ration. More details about the tests, diets, and managements appear in Gomes et al (2013), Santana et al (2013), and Alexandre et al (2015).…”

Section: Animals and Phenotypementioning

confidence: 99%

Copy number variations and genome-wide associations reveal putative genes and metabolic pathways involved with the feed conversion ratio in beef cattle

et al. 2016

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The use of genome-wide association results combined with other genomic approaches may uncover genes and metabolic pathways related to complex traits. In this study, the phenotypic and genotypic data of 1475 Nellore (Bos indicus) cattle and 941,033 single nucleotide polymorphisms (SNPs) were used for genome-wide association study (GWAS) and copy number variations (CNVs) analysis in order to identify candidate genes and putative pathways involved with the feed conversion ratio (FCR). The GWAS was based on the Bayes B approach analyzing genomic windows with multiple regression models to estimate the proportion of genetic variance explained by each window. The CNVs were detected with PennCNV software using the log R ratio and B allele frequency data. CNV regions (CNVRs) were identified with CNVRuler and a linear regression was used to associate CNVRs and the FCR. Functional annotation of associated genomic regions was performed with the Database for Annotation, Visualization and Integrated Discovery (DAVID) and the metabolic pathways were obtained from the Kyoto Encyclopedia of Genes and Genomes (KEGG). We showed five genomic windows distributed over chromosomes 4, 6, 7, 8, and 24 that explain 12 % of the total genetic variance for FCR, and detected 12 CNVRs (chromosomes 1, 5, 7, 10, and 12) significantly associated [false discovery rate (FDR) < 0.05] with the FCR. Significant genomic regions (GWAS and CNV) harbor candidate genes involved in pathways related to energetic, lipid, and protein metabolism. The metabolic pathways found in this study are related to processes directly connected to feed efficiency in beef cattle. It was observed that, even though different genomic regions and genes were found between the two approaches (GWAS and CNV), the metabolic processes covered were related to each other. Therefore, a combination of the approaches complement each other and lead to a better understanding of the FCR.

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“…As Anaerovibrios têm sido associadas à produção de succinato e propionato, bem como a hidrólise lipídica e metabolismo em ruminantes (PRIVE et al, 2013 Para as análises posteriores foi realizada a filtragem para exclusão de filos por baixa prevalência/abundância, onde os filos "Chlamydiae", "Chloroflexi", "Cyanobacteria/Chloroplast", "Thaumarchaeota" e "Parcubacteria" foram excluídos. GOMES et al, 2013;SANTANA et al, 2012, 2013, 2014, ALEXANDRE et al 2015.…”

Section: A Importância Do Microbioma Para a Eficiência Alimentarunclassified

“…Todavia, observa-se diferença significativa nas medidas de EA e no IMS, sendo esta última menor nos animais de AEA. Esse resultado é consistente com a proposta da medida de CAR (KOCH et al, 1963) que visa identificar animais que ingerem menos alimento mantendo o ganho de peso, e estão de acordo com outros estudos em Bos indicus e Bos taurus (ARTHUR;RENAND;KRAUSS, 2001;GOMES et al, 2013;SANTANA et al, 2013;ALEXANDRE et al, 2015). al., 2014;MYER et al, 2015MYER et al, , 2017.…”

Section: A Importância Do Microbioma Para a Eficiência Alimentarunclassified

Avaliação da associação entre microbioma fecal e eficiência alimentar em bovinos da raça Angus

Marcilli¹

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Blood cell and metabolic profile of Nellore bulls and their correlations with residual feed intake and feed conversion ratio

Abstract: Blood cell and metabolic profile of Nellore bulls and their correlations with residual feed intake and feed conversion ratioPerfis sanguíneo e metabólico de touros Nelore e suas correlações com consumo alimentar residual e taxa de conversão alimentar

Cited by 12 publications

References 12 publications

Short Communication Genome-wide association with residual body weight gain in Bos indicus cattle

Short Communication Genome-wide association with residual body weight gain in Bos indicus cattle

Copy number variations and genome-wide associations reveal putative genes and metabolic pathways involved with the feed conversion ratio in beef cattle

Avaliação da associação entre microbioma fecal e eficiência alimentar em bovinos da raça Angus

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