Blood brain barrier permeability and immune function of brain in rainbow trout responding to IHNV infection

Sun, Ruhan; Chen, Kai-Wei; Wang, Qin; Huang, Zhenyu; Wang, Bingchao; Shi, Ze-Chao; Ji, Wei

doi:10.1016/j.dci.2022.104482

Cited by 3 publications

(1 citation statement)

References 55 publications

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“…Salmonid alphavirus can infect Atlantic salmon via immersion route and lead to skin dysbiosis (Reid et al., 2017). Infectious haematopoietic necrosis virus (IHNV) can invade the gut mucosa and brain of rainbow rout via immersion route, leading to severe tissue damage and inflammation (Huang et al., 2022; Sun et al., 2022). Therefore, blocking transmission routes is one of the effective means to control the diffusion of this waterborne virus.…”

Section: Introductionmentioning

confidence: 99%

Experimental evidence of effective disinfectant to control the transmission of Micropterus salmoides rhabdovirus

He,

Zhu,

Chen

et al. 2023

Journal of Fish Diseases

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Micropterus salmoides rhabdovirus (MSRV) is a significant pathogen that causes high morbidity and mortality in largemouth bass, leading to enormous economic losses for largemouth bass aquaculture in China. The aim of this study was to investigate the efficacy of four disinfectants (potassium permanganate, glutaraldehyde, trichloroisocyanuric acid and povidone iodine) on MSRV, to control the infection and transmission of MSRV in largemouth bass aquaculture. The disinfectants were tested at different concentrations (5, 25, 50, 100 and 500 mg/L) prepared with distilled water for 30 min contact time, and the viral nucleic acid was quantified using qPCR and the infectivity was tested by challenge experiment. Potassium permanganate at 5–500 mg/L, glutaraldehyde at 500 mg/L, trichloroisocyanuric acid at 50–500 mg/L and povidone iodine at 500 mg/L concentration could effectively decrease the virus nucleic acid, and the survival rate of largemouth bass juveniles after challenge experiment increased significantly from 3.7% ± 6.41% to 33.33 ± 11.11% – 100%. Moreover, the minimum effective time of 5 mg/L potassium permanganate was further studied at 2, 5, 10 and 20 min contact time. The viral nucleic acid decreased significantly at 5–20 min exposure time, and the survival rate increased significantly from 7.41% ± 6.41% to 77.78 ± 11.11% – 100%. The median lethal concentration (LC50) values of potassium permanganate were 10.64, 6.92 and 3.7 mg/L at 24, 48 and 96 h, respectively. Potassium permanganate could be used for the control of MSRV in the cultivation process; the recommended concentration is 5 mg/L and application time should be less than 24 h. The results could be applied to provide a method to control the infection and transmission of MSRV in water, and improve the health status of largemouth bass.

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Section: Introductionmentioning

confidence: 99%

Experimental evidence of effective disinfectant to control the transmission of Micropterus salmoides rhabdovirus

He,

Zhu,

Chen

et al. 2023

Journal of Fish Diseases

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The knowns and many unknowns of CNS immunity in teleost fish

Mani¹,

Salinas²

2022

Fish & Shellfish Immunology

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Comparative Study on Immune Function of the Head and Trunk Kidney in Rainbow Trout Responding to IHNV Infection

Sun

Wang

Huang

et al. 2022

Viruses

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A teleost’s kidney was divided into head kidney and trunk kidney. The head kidney is an important lymphatic organ, while the trunk kidney mainly performs osmotic pressure regulation and excretion functions. Previous studies have shown that the teleost’s head kidney exerts a strong immune response against pathogen invasion, while the mechanism of immune response in the trunk kidney is still rarely reported. Therefore, in this study, we established an Infectious hematopoietic necrosis virus (IHNV) immersion infection model to compare the similarities and differences of immune response mechanisms between the head kidney and trunk kidney against viral infection. The results showed that IHNV infection causes severe tissue damage and inflammatory reaction in the head and trunk kidney, triggers a series of interferon cascade reactions, and produces strong immune response. In addition, the transcriptome data showed that the head kidney and trunk kidney had similar immune response mechanisms, which showed that the NOD-like receptor signaling pathway and Toll-like receptor signaling pathway were activated. In conclusion, despite functional differentiation, the teleost’s trunk kidney still has a strong immune response, especially the interferon-stimulated genes, which have stronger immune response in the trunk kidney than in the head kidney when responding to IHNV infection. This study contributes to a more comprehensive understanding of the teleost immune system and enriches the theory of kidney immunity in teleosts.

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Blood brain barrier permeability and immune function of brain in rainbow trout responding to IHNV infection

Cited by 3 publications

References 55 publications

Experimental evidence of effective disinfectant to control the transmission of Micropterus salmoides rhabdovirus

Experimental evidence of effective disinfectant to control the transmission of Micropterus salmoides rhabdovirus

The knowns and many unknowns of CNS immunity in teleost fish

Comparative Study on Immune Function of the Head and Trunk Kidney in Rainbow Trout Responding to IHNV Infection

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