Blood basophils in lung cancer

Anthony, Honor M.

doi:10.1038/bjc.1982.35

Cited by 22 publications

(7 citation statements)

References 16 publications

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“…Basophils are known to be involved in immediate hypersensitivity and cutaneous basophil hypersensitivity. Anthony (1982) demonstrated that basophil counts were elevated in patients with squamous bronchial carcinoma and caused worse clinical conditions. Classical inflammatory monocytes and their derivative macrophages promote tumor metastasis (Cassetta and Pollard, 2015).…”

Section: Discussionmentioning

confidence: 99%

Correlation of Glasgow Prognostic Score or Procalcitonin to Clinical Variables in Patients with Pretreatment Lung Cancer

Kim¹,

Seok²,

Hyun³

et al. 2016

BSL

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Unfortunately, the five-year survival rate of lung cancer is relatively low compared with other cancers. Therefore, better predictors are need for prognosis, therapeutic strategy, risk stratification and predicting long-term mortality of lung cancer. Recently, increasing data suggest that Glasgow Prognostic Score (GPS) and procalcitonin levels are useful predictor cancer prognosis. In this study, we retrospectively investigated the correlation of GPS or procalcitonin to clinical variables in patients with pretreatment lung cancer. In 135 patients with pretreatment lung cancer, GPS, procalcitonin, demographic characteristics, hematological, coagulation, biochemical, inflammatory and cardiac markers were measured. Monocyte, eosinophil, basophil, neutrophil to lymphocyte ratio, red cell distribution width (RDW), platelet to lymphocyte ratio, mean platelet volume to platecrit ratio, D-dimer and prothrombin time (PT) levels were higher, whereas mean platelet volume was lower than their normal ranges. Glucose and sodium levels were low, whereas gamma glutamyl transferase (GGT), total bilirubin, creatinine and inorganic phosphorus concentrations were increase compared their normal ranges. Procalcitonin, high sensitivity C-reactive protein and troponin-I concentrations were elevated compared with their normal ranges. GPS had significantly positive or negative relations to cancer stage, hematological, coagulation, biochemical, inflammatory and troponin-I. Based on the data, we suggest that GPS may be a potent and useful predictor for prognosis, therapeutic strategy, risk stratification and predicting long-term mortality of lung cancer.

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Section: Discussionmentioning

confidence: 99%

Correlation of Glasgow Prognostic Score or Procalcitonin to Clinical Variables in Patients with Pretreatment Lung Cancer

Kim¹,

Seok²,

Hyun³

et al. 2016

BSL

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“…De Monte et al (47) revealed that the infiltration of BAs in tumor-draining lymph nodes was associated with the Th2/Th1 cell ratio in tumors and was responsible for the presence of IL-4 in pancreatic cancer. In addition, the counts of circulating BAs in patients with non-small cell lung cancer were higher compared with in healthy individuals (50). Furthermore, in a mouse model of metastatic breast cancer generated by implanting 4T1 cells into the mammary fat pads, Wang et al (21) reported that circulating BAs were negatively associated with the number of lung metastases.…”

Section: ------------------------------------------------------------mentioning

confidence: 99%

Values of applying white blood cell counts in the prognostic evaluation of resectable colorectal cancer

Zhu

et al. 2019

Mol Med Report

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The count and classification of white blood cells (WBCs) may be used as prognostic markers in certain types of cancer. The present study investigated the prognostic potential of the counts of WBCs, including lymphocytes (LYs), monocytes (MOs), neutrophils (NEs), eosinophils (EOs) and basophils (BAs), in the prognosis of resectable colorectal cancer. The present study recruited 153 resectable colorectal cancer cases retrospectively, which were pathologically confirmed. All patients were divided into two groups, according to the median value of LY (low LY, ≤1.632x10 9 /l or high LY, >1.632x10 9 /l), MO (low MO, ≤0.330x10 9 /l or high MO, >0.330x10 9 /l), NE (low NE, ≤3.600x10 9 /l or high NE, >3.600x10 9 /l), EO (low EO, ≤0.085x10 9 /l or high EO, >0.085x10 9 /l), BA (low BA, ≤0.010x10 9 /l or high BA, >0.010x10 9 /l), or WBC (low WBC, ≤5.780x10 9 /l or high WBC, >5.780x10 9 /l). To evaluate the alterations in WBC counts following surgery and adjuvant chemotherapy; all samples received oxiplatin and capecitabine (XELOX) for 6-8 cycles or 5-fluorouracil, leucovorin and oxaliplatin (mFOLFOX6) for 10-12 cycles. XELOX included oxaliplatin administered intravenously at a dose of 130 mg/m 2 on day 1 and 850-1,250 mg/m 2 capecitabine twice daily for days 1-14, repeated every 3 weeks. mFOLFOX6 included oxaliplatin administered intravenously at a dose of 85 mg/m 2 , 400 mg/m 2 leucovorin and 400 mg/m 2 5-FU on day 1 followed by 1,200 mg/m 2 /days continuous infusion for 2 days (in total, 2,400 mg/m 2 over 46-48 h), repeated every 2 weeks. The present study investigated the post/pre-treatment of LY, MO, NE, EO, BA and WBC ratios (≤1 indicated that LY, MO, NE, EO, BA and WBC counts were not increased following therapy; whereas, >1 suggested increased counts). Kaplan-Meier curves were constructed to demonstrate overall survival (OS). A multivariate and univariate logistic regression analyses model was employed to identify the independent risk factors. Low pre-treatment BA counts were associated with larger tumor size (>5 cm); pre-treatment BA levels were positively associated with OS. Surgery significantly decreased the count of BAs and increased the count of EOs; whereas, no effect was observed on LYs, MOs, NEs or WBCs. Adjuvant chemotherapy markedly decreased the counts of LY, NE and WBC; whereas, no notable effects on MOs, EOs or BAs were observed. Whole course treatment (surgery combined with adjuvant chemotherapy) significantly decreased the values of LY, NE and WBC; however, increased the value of EO; no effects on the MO or BA counts were observed. An increased post-/pre-treatment NE ratio suggested poorer prognosis. Multivariate Cox regression analysis revealed that sex, tumor size, pre-treatment BA count and the post-/pre-treatment NE ratio were independent prognostic factors affecting OS. The results of the present study suggested that the pre-treatment BA count and post-/pre-treatment NE ratio may be potential prognostic factors for resectable colorectal cancer.

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“…Increased basophil counts have been reported in hematologic and solid tumors . However, the role of circulating and tissue resident basophils in human and experimental cancer is almost unexplored in the vast majority of tumor types.…”

Section: Role Of Mast Cells and Basophils In Health And Diseasementioning

confidence: 99%

“…Increased basophil counts have been reported in hematologic [461][462][463] and solid tumors. 464 However, the role of circulating and tissue resident basophils in human and experimental cancer is almost unexplored in the vast majority of tumor types. Basophils infiltrate human gastric mucosa of Helicobacter pylori-infected patients affected by severe gastritis and cancer.…”

Section: Basophils and Cancermentioning

confidence: 99%

Human mast cells and basophils—How are they similar how are they different?

Varricchi

Raap

Rivellese

et al. 2018

Immunological Reviews

126

116

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Mast cells and basophils are key contributors to allergies and other inflammatory diseases since they are the most prominent source of histamine as well as numerous additional inflammatory mediators which drive inflammatory responses. However, a closer understanding of their precise roles in allergies and other pathological conditions has been marred by the considerable heterogeneity that these cells display, not only between mast cells and basophils themselves but also across different tissue locations and species. While both cell types share the ability to rapidly degranulate and release histamine following high-affinity IgE receptor cross-linking, they differ markedly in their ability to either react to other stimuli, generate inflammatory eicosanoids or release immunomodulating cytokines and chemokines. Furthermore, these cells display considerable pharmacological heterogeneity which has stifled attempts to develop more effective anti-allergic therapies. Mast cell- and basophil-specific transcriptional profiling, at rest and after activation by innate and adaptive stimuli, may help to unravel the degree to which these cells differ and facilitate a clearer understanding of their biological functions and how these could be targeted by new therapies.

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Blood basophils in lung cancer

Cited by 22 publications

References 16 publications

Correlation of Glasgow Prognostic Score or Procalcitonin to Clinical Variables in Patients with Pretreatment Lung Cancer

Correlation of Glasgow Prognostic Score or Procalcitonin to Clinical Variables in Patients with Pretreatment Lung Cancer

Values of applying white blood cell counts in the prognostic evaluation of resectable colorectal cancer

Human mast cells and basophils—How are they similar how are they different?

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