Blood banking–induced alteration of red blood cell flow properties

Relevy, Hanna; Koshkaryev, Alexander; Manny, Noga; Yedgar, Saul; Barshtein, Gregory

doi:10.1111/j.1537-2995.2007.01491.x

Cited by 180 publications

(220 citation statements)

References 68 publications

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“…Membrane loss during red blood cell storage would appear to be permanent. As storage progresses, red blood cells become more rigid and more adherent to endothelium [18,19].…”

Section: Standards For Red Blood Cell Storage: Recovery Survival Andmentioning

confidence: 99%

Current issues relating to the transfusion of stored red blood cells

Zimrin¹,

2009

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The development of blood storage systems allowed donation and transfusion to be separated in time and space. This separation has permitted the regionalization of donor services with subsequent economies of scale and improvements in the quality and availability of blood products. However, the availability of storage raises the question of how long blood products can and should be stored and how long they are safe and effective. The efficacy of red blood cells was originally measured as the increment in haematocrit and safety began with typing and the effort to reduce the risk of bacterial contamination. Appreciation of a growing list of storage lesions of red blood cells has developed with our increasing understanding of red blood cell physiology and our experience with red blood cell transfusion. However, other than frank haemolysis, rare episodes of bacterial contamination and overgrowth, the reduction of oxygen-carrying capacity associated with the failure of some transfused cells to circulate, and the toxicity of lysophospholipids released from membrane breakdown, storage-induced lesions have not had obvious correlations with safety or efficacy. The safety of red blood cell storage has also been approached in retrospective epidemiologic studies of transfused patients, but the results are frequently biased by the fact that sicker patients are transfused more often and blood banks do not issue blood products in a random order. Several large prospective studies of the safety of stored red blood cells are planned.

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“…Membrane loss during red blood cell storage would appear to be permanent. As storage progresses, red blood cells become more rigid and more adherent to endothelium [18,19].…”

Section: Standards For Red Blood Cell Storage: Recovery Survival Andmentioning

confidence: 99%

Current issues relating to the transfusion of stored red blood cells

Zimrin¹,

2009

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“…Reversible and irreversible changes to the function and properties of RBCs can be observed as early as 14 days after collection (Table 4) [36]. Stored units of blood experience progressive biochemical and morphological deterioration resulting in RBCs that have compromised viability, cell size, deformability, and lipid-membrane composition (Table 4) [7,8,34,37,38]. In addition, prolonged storage leads to accumulation of potentially harmful debris, most notably, aggregates of oxidized membrane lipids and proteins [7,34,39].…”

Section: Storage Lesionmentioning

confidence: 99%

Storage of Red Blood Cells and Transfusion-Related Acute Lung Injury

Babaev

Pozzi

Hare

et al. 2014

JACCOA

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Transfusion-related acute lung injury (TRALI) is a major complication posttransfusion. A consensus definition of TRALI has been recently established to improve diagnosis but the pathogenesis of TRALI is yet to be understood. Although the antibody-mediated two-hit model of TRALI is the classical narrative, increasing evidence of the probable implications of prolonged storage of blood provides novel mechanisms towards storage lesion-the potentially injurious cellular and biochemical changes that occur in stored red blood cells. Red blood cell-derived lipids and micro vesicles may have been playing an important role in the development of TRALI. This article will provide a brief overview of the current understanding of TRALI and then discuss the implications and the potential mechanisms by which stored red blood cells may lead to TRALI. TRALI is characterized by clinical features that include, but not limited to, dyspnea, tachypnea, respiratory insufficiency, noncardiogenic bilateral pulmonary edema, decreased pulmonary compliance and acute hypoxemia (PaO 2 /FiO 2 <300 mmHg, (Table 1) [13,14]. KeywordsThe incidence of TRALI ranges from 1/5,000-1/1,323 transfusions within the general population and it is the leading cause of transfusion-related death in the United States [15]. Such large range in incidence could be attributed to the relatively unspecific diagnostics tools available for TRALI, past cases of under-diagnosis or misdiagnosis, and the elevated incidence of TRALI within vulnerable populations [14][15][16]. A recent study analyzing the incidence of TRALI in critically ill patients admitted to intensive care unit (ICU) observed that over 5% of all patients who received blood transfusion developed TRALI, which is 50-100 times greater occurrence than in the general hospital population [12,17]. Risk factors related to recipients and donorsThe risk factors of TRALI are highly diverse, among patients DefinitionDiagnostic Parameters TRALIBi-lateral infiltrates with non-cardiogenic pulmonary edema. ARDS appearance within 6hours after transfusion. Hypoxemia: PaO 2 /F i O 2 < 300 mmHg. Potential TRALI Similar to TRALI diagnosis with an additional risk-factor for lung injury/ARDS. Delayed TRALI Diagnostic parameters characteristic of TRALI within 24-72 hours after transfusion.

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“…Such damage to the cellular membrane results in impairment of the cell membrane functions or deterioration of the cell viability [15][16][17][18][19][20][21]. Although the ultrastructure of the RBC membrane plays a pivotal role in cellular regulation and function, little information is available concerning the impact of gamma irradiation on the RBC membrane ultrastructure.…”

Section: Introductionmentioning

confidence: 99%

Nanostructural Changes in the Cell Membrane of Gamma-Irradiated Red Blood Cells

Alzahrani

Al-Sewaidan

2016

Indian J Hematol Blood Transfus

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The effect of gamma radiation on the ultrastructure of the cell membranes of red blood cells has been probed using a powerful tool, namely, atomic force microscopy. We used mice erythrocytes as a model. Blood samples withdrawn from mice were gamma-irradiated using a 60 Co source unit with doses of 10,15,20,25 and 30 Gy. Structural changes appeared in the form of nanoscale potholes, depressions and alterations of the cell membrane roughness. The roughness of the cell membrane increased dramatically with increasing doses, although at 10 Gy, the cell membrane roughness was less than that of normal red blood cells (controls). Therefore, such modifications at the nano-scale level may affect the biophysical properties of membranes, resulting in impairment of their function.

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Blood banking–induced alteration of red blood cell flow properties

Cited by 180 publications

References 68 publications

Current issues relating to the transfusion of stored red blood cells

Current issues relating to the transfusion of stored red blood cells

Storage of Red Blood Cells and Transfusion-Related Acute Lung Injury

Nanostructural Changes in the Cell Membrane of Gamma-Irradiated Red Blood Cells

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