Blocking tubules technologies for dentin hypersensitivity in periodontal patients – pilot study

Abstract

Periodontal patients often report dentin hypersensitivity (DH) caused by root surface exposure or periodontal treatment. Tubular blocking technologies in toothpastes are effective for pain relief, but no specific chemical/physical agent has been reported for periodontal patients. This double-blind randomized clinical trial compared the effects of three technologies in reducing DH in periodontal patients. Eighteen (18) participants were randomly assigned into three groups: SEN (NOVAMIN technology); REG (REFIX technology); REGK (REFIX technology + potassium citrate). Periodontal patients presenting with DH were evaluated at 6 moments: T1 and T2 - immediately before and after scaling and root planing procedures (SRP); T3 - after polishing sensitive areas with their assigned dentifrice and T4, T5, T6 - after 2, 4 and 8 weeks of SRP respectively. Sensitivity was assessed by air blast (Schiff scale) and patients’ perceptions using the visual analogue scale (VAS). Data were analyzed by two-way repeated measures ANOVA complemented by the Tukey test with significance set at 5% (p <0.05). Preliminary outcomes revealed SEN, REG and REGP reduced DH in periodontal patients (n=18). All patients initially presented moderate to severe pain (64.3) and after treatment they reported mild pain (21.3). Similarly, the dentist evaluation showed significant reduction in DH with the use of the three technologies (2.26 to 0.56). No statistically significant differences were found between the three study groups for patients (p=0.751) and dentist evaluations (p=0.632). According to these preliminary outcomes, all three technologies equally reduced DH in periodontal patients. Clinical trials #NCT04422184

A novel clinical protocol for dentin hypersensitivity management based on regenerative dental gel associated with calcium: A case study in a patient with periodontal disease

“…A short-lived, sharp, localized, transitory pain caused by the exposure of the dentin is known as dentine hypersensitivity (DH) [1][2][3][4][5][6]. A considerable section of the population is affected by DH, which causes discomfort and has an adverse effect on the oral health and quality of life [3,4,7].…”

“…Its prevalence in the adult population ranges from 3% to 57%, and in patients with periodontal disease, it can reach up to 98% (PD). More women than men are being affected in the majority [3,6].…”

“…The treatments are based on two strategies: either preventing fluid movement by obliterating the dentinal tubules or blocking the nerve signals to the pulpal receptors, which disrupts the body's response to painful stimuli [5,6]. Finding a treatment that is quick, effective, and eliminates the painful sensation of hypersensibility while preventing recurrence is one of the major challenges facing dentistry today [5].…”

“…Bioactive agents derived from calcium and/or siliconbased systems, such as REFIX technology, have been used in dental gels to promote tooth remineralization/ regeneration, with focus on tooth sensitivity treatment [3,6,8,9,10,11].…”

“…These ionic alterations reduce hydroxyapatite solubility, lowering dentinal fluid movement and enhancing mechanical characteristics. It prevents DH, particularly in PD patients [3,6,[9][10][11].…”