Abstract:Introduction GFA (Guan-Fu Base A) as one of the main active
substances in the Chinese medicine Ranunculaceae Aconite, has been
approved the effect of anti-atrial fibrillation via its atrial-selective
Na channel-blocking action. It is recently
undergoing phase IV clinical study. However, the molecular mechanism of
Na 1.5 channel inhibition by GFA is largely unclear.
Methods and Results Na 1.5 channel and its
mutants were expressed in Xenopus oocytes and the currents were
recorded with two-microelectrode voltag… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.