Chinese herbal medicine for the treatment of cardiovascular diseases ─ Targeting cardiac ion channels

Yan, Zhenzhen; Zhong, Ling; Zhu, Wandi; Chung, Sookja K.; Hou, Panpan

doi:10.1016/j.phrs.2023.106765

Cited by 4 publications

(1 citation statement)

References 416 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Arrhythmias often result from alterations in the electrophysiological properties of cardiomyocytes and their underlying ion channels [ 70 ]. Numerous studies have indicated that garlic and garlic extract can improve arrhythmias through modulation of ion channels [ 71 ].…”

Section: Allicin In the Treatment Of Cvdmentioning

confidence: 99%

Therapeutic potentials of allicin in cardiovascular disease: advances and future directions

Gao,

Wang,

Qin

et al. 2024

Chin Med

View full text Add to dashboard Cite

Cardiovascular disease (CVD) remains the predominant cause of mortality and disability worldwide. Against this backdrop, finding effective drugs for the pharmacological treatment of CVD has become one of the most urgent and challenging issues in medical research. Garlic (Allium sativum L.) is one of the oldest plants and is world-renowned for its dietary and medicinal values. Allicin (diallyl thiosulfinate) is one of the primary natural active ingredients in garlic, which has been proven to have powerful cardioprotective effects and mediate various pathological processes related to CVD, such as inflammatory factor secretion, myocardial cell apoptosis, oxidative stress, and more. Therefore, allicin holds a promising application prospect in the treatment of CVD. This review summarized the biological functions of allicin and its potential mechanisms in CVD, including antioxidation, anti-inflammation, and anti-apoptosis effects. Reckoning with these, we delved into recent studies on allicin’s cardioprotective effects concerning various CVDs, such as atherosclerosis, hypertension, myocardial infarction, arrhythmia, cardiac hypertrophy, heart failure, and cardiotoxicity. Further, considering the tremendous advancement in nanomedicine, nanotechnology-based drug delivery systems show promise in addressing limitations of allicin’s clinical applications, including improving its solubility, stability, and bioavailability. Through this review, we hope to provide a reference for further research on allicin in cardioprotection and drug development. Graphical Abstract

show abstract

Section: Allicin In the Treatment Of Cvdmentioning

confidence: 99%