Cell Reports volume 3, issue 3, P595-606 2013 DOI: 10.1016/j.celrep.2013.02.017 View full text
Gunnar Newquist, J. Michelle Drennan, Matthew Lamanuzzi, Kirsti Walker, James C. Clemens, Thomas Kidd

Abstract: SUMMARY Netrins are guidance cues that form gradients to guide growing axons. We uncover a mechanism for axon guidance by demonstrating that axons can accurately navigate in the absence of a Netrin gradient if apoptotic signaling is blocked. Deletion of the two Drosophila NetA and NetB genes leads to guidance defects and increased apoptosis, and expression of either gene at the midline is sufficient to rescue the connectivity defects and cell death. Surprisingly, pan-neuronal expression of NetB rescues equall…

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