Control of Male and Female Fertility by the Netrin Axon Guidance Genes

Newquist, Gunnar; Hogan, Jesse; Walker, Kirsti; Lamanuzzi, Matthew; Bowser, Micah; Kidd, Thomas

doi:10.1371/journal.pone.0072524

Cited by 10 publications

(8 citation statements)

References 68 publications

(86 reference statements)

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“…Netrin is a diffusible laminin-like protein and conserved from worms to mammals. In Drosophila , the NetAB mutants exhibit egg-laying defects due to ovulation defects in females [79]. The clathrin heavy chain gene, FRP gene (three copies) and NetAB genes could be found in the N. cucumeris genome (Additional file 1: Table S14), indicating that they perhaps function similarly in the regulation of oviposition in N. cucumeris .…”

Section: Resultsmentioning

confidence: 99%

Genomic insights into mite phylogeny, fitness, development, and reproduction

et al. 2019

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BackgroundPredatory mites (Acari: Phytoseiidae) are the most important beneficial arthropods used in augmentative biological pest control of protected crops around the world. However, the genomes of mites are far less well understood than those of insects and the evolutionary relationships among mite and other chelicerate orders are contested, with the enigmatic origin of mites at one of the centres in discussion of the evolution of Arachnida.ResultsWe here report the 173 Mb nuclear genome (from 51.75 Gb pairs of Illumina reads) of the predatory mite, Neoseiulus cucumeris, a biocontrol agent against pests such as mites and thrips worldwide. We identified nearly 20.6 Mb (~ 11.93% of this genome) of repetitive sequences and annotated 18,735 protein-coding genes (a typical gene 2888 bp in size); the total length of protein-coding genes was about 50.55 Mb (29.2% of this assembly). About 37% (6981) of the genes are unique to N. cucumeris based on comparison with other arachnid genomes. Our phylogenomic analysis supported the monophyly of Acari, therefore rejecting the biphyletic origin of mites advocated by other studies based on limited gene fragments or few taxa in recent years. Our transcriptomic analyses of different life stages of N. cucumeris provide new insights into genes involved in its development. Putative genes involved in vitellogenesis, regulation of oviposition, sex determination, development of legs, signal perception, detoxification and stress-resistance, and innate immune systems are identified.ConclusionsOur genomics and developmental transcriptomics analyses of N. cucumeris provide invaluable resources for further research on the development, reproduction, and fitness of this economically important mite in particular and Arachnida in general.

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Section: Resultsmentioning

confidence: 99%

Genomic insights into mite phylogeny, fitness, development, and reproduction

et al. 2019

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“…These findings indicated that the hmbRBC meal affects gene expression of the modulatory machinery at neural synapses. Moreover, axon guidance protein gene (AGAP008943), homologous to turtle in Drosophila (CG16857), as well as dopamine b-monooxygenase (AGAP010485) are known to be indirectly involved in oogenesis (23).…”

Section: Process Name Functionmentioning

confidence: 99%

A key malaria metabolite modulates vector blood seeking, feeding, and susceptibility to infection

Emami

Lindberg

Hua

et al. 2017

Science

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Malaria infection renders humans more attractive to sensu lato mosquitoes than uninfected people. The mechanisms remain unknown. We found that an isoprenoid precursor produced by, ()-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP), affects s.l. blood meal seeking and feeding behaviors as well as susceptibility to infection. HMBPP acts indirectly by triggering human red blood cells to increase the release of CO, aldehydes, and monoterpenes, which together enhance vector attraction and stimulate vector feeding. When offered in a blood meal, HMBPP modulates neural, antimalarial, and oogenic gene transcription without affecting mosquito survival or fecundity; in a -infected blood meal, sporogony is increased.

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“…94 In contrast, netrin is dispensable for cell survival, and global netrin-AB mutants have apparently wild-type egg chambers. 94,95 While this pattern of cell death does not fit the dependence receptor model, it raises the possibility that Frazzled may interact with cell death machinery by an alternate mechanism. Similarly, netrin-Neogenin signaling in the mammary gland may impinge on the cell death machinery by an as-yet-unknown mechanism.…”

Section: Guidance Pathways Regulate Mammary Gland Remodelingmentioning

confidence: 89%

Diverse roles for axon guidance pathways in adult tissue architecture and function

Laws

Bashaw

2022

Natural Sciences

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Classical axon guidance ligands and their neuronal receptors were first identified due to their fundamental roles in regulating connectivity in the developing nervous system. Since their initial discovery, it has become clear that these signaling molecules play important roles in the development of a broad array of tissue and organ systems across phylogeny. In addition to these diverse developmental roles, there is a growing appreciation that guidance signaling pathways have important functions in adult organisms, including the regulation of tissue integrity and homeostasis. These roles in adult organisms include both tissue‐intrinsic activities of guidance molecules, as well as systemic effects on tissue maintenance and function mediated by the nervous and vascular systems. While many of these adult functions depend on mechanisms that mirror developmental activities, such as regulating adhesion and cell motility, there are also examples of adult roles that may reflect signaling activities that are distinct from known developmental mechanisms, including the contributions of guidance signaling pathways to lineage commitment in the intestinal epithelium and bone remodeling in vertebrates. In this review, we highlight studies of guidance receptors and their ligands in adult tissues outside of the nervous system, focusing on in vivo experimental contexts. Together, these studies lay the groundwork for future investigation into the conserved and tissue‐specific mechanisms of guidance receptor signaling in adult tissues. Key Points Axon guidance ligand and receptor expression often persist into adulthood in neuronal and non‐neuronal tissues alike. Recent work in genetic model organisms highlights the diverse roles of guidance factors in adult tissues. Guidance factors are required intrinsically in a variety of adult tissues but can also regulate tissue function indirectly via functions in the nervous and vascular systems. Studies outside of the nervous system are likely to enhance our understanding of these diverse siganling molecules and could suggest novel signaling modalities in the nervous system.

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Control of Male and Female Fertility by the Netrin Axon Guidance Genes

Cited by 10 publications

References 68 publications

Genomic insights into mite phylogeny, fitness, development, and reproduction

Genomic insights into mite phylogeny, fitness, development, and reproduction

A key malaria metabolite modulates vector blood seeking, feeding, and susceptibility to infection

Diverse roles for axon guidance pathways in adult tissue architecture and function

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