Blockade of sympathetic β-receptors inhibits Porphyromonas gingivalis-induced alveolar bone loss in an experimental rat periodontitis model

Okada, Yoshinori; Hamada, Naoki; Kim, Yul; Takahashi, Yusuke; Sasaguri, Kenichi; Ozono, Satoru; Sato, Sadao

doi:10.1016/j.archoralbio.2010.04.002

Cited by 35 publications

(33 citation statements)

References 30 publications

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“…The increase in the oral symptoms related to periodontal disease leads us to assume that it is linked to the deterioration of oral hygiene among victims after the GEJE. Periodontal disease, a major chronic infectious disease, can also be exacerbated by psychological stress and depression followed by the dysregulation of the cellular and humoral pathways of the immune system (Okada et al 2010;Warren et al 2014). Similarly, sleep disturbances increase with psychological stress and infectious diseases (Irwin 2015).…”

Section: Discussionmentioning

confidence: 99%

Periodontal Disease Is Associated with Insomnia among Victims of the Great East Japan Earthquake: A Panel Study Initiated Three Months after the Disaster

Tsuchiya

Aida

Hagiwara

et al. 2015

Tohoku J. Exp. Med.

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In March 2011, the Great East Japan Earthquake (GEJE), which was followed by a devastating tsunami, destroyed the societal and the public hygiene systems in Japanese coastal areas. Insomnia, the greatest issue among disaster victims, has detrimental effects on both physical and psychological health. Periodontitis causes chronic discomfort and inflammation, and little is known about its impact on insomnia. Three months after the earthquake, a health panel survey was conducted over four surveys, till September 2013, in which information regarding 8,015 adults was collected and used. In addition to the heath-related questionnaire, other variables including subjective symptoms of oral diseases were recorded, and the Athens Insomnia Scale was used to evaluate the severity of insomnia. The association between insomnia and periodontal disease was examined using multilevel logistic models on the panel data, after adjusting for sex, age, economic status, comorbidities, body mass index, post-traumatic stress reactions, habitual smoking and alcohol drinking, and the Kessler Psychological Distress Scale score. In addition to the higher prevalence of insomnia among GEJE victims, significant association was revealed between insomnia and gum problems (OR = 2.16, 95% CI = 1.43-3.26), and difficulty chewing (OR = 2.22, 95% CI = 1.40-3.51), after adjusting for all covariates. The present study revealed significant association between insomnia and periodontal disease among GEJE victims. This indicated that together, integrated oral health care for disaster victims would contribute not only to prevention of oral infectious diseases, but may also help alleviate other problems caused by these harmful events.

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Section: Discussionmentioning

confidence: 99%

Periodontal Disease Is Associated with Insomnia among Victims of the Great East Japan Earthquake: A Panel Study Initiated Three Months after the Disaster

Tsuchiya

Aida

Hagiwara

et al. 2015

Tohoku J. Exp. Med.

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“…Existing laboratory rat models for mild and moderate human PD (Oz & Puleo, 2011; Graves et al, 2012; Struillou et al, 2010) include ligature-induced localized PD (Cesar Neto, de Souza, Barbieri, & Sallum, 2004; Lohinai, Benedek, & Feher, 1998), LPS-injection-induced localized PD (Dumitrescu, Abd-El-Aleem, Morales-Aza, & Donaldson, 2004; Nakamura, Ukai, & Yoshimura, 2010), and bacterial-inoculation-induced PD (Li et al, 2010; Lohinai et al, 1998; Okada, Hamada, & Kim, 2010). Each, with a known initiation date and requirement for ongoing maintenance or injection/inoculation, causes development of either localized or generalized tissue level PD similar to moderate PD in humans and permits studies of both the induction phase itself, and of preventive or remedial treatments of 2–8 weeks duration.…”

Section: Introductionmentioning

confidence: 99%

Age-related periodontitis and alveolar bone loss in rice rats

Aguirre

Akhter

Neuville

et al. 2017

Archives of Oral Biology

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Objective To characterize in rice rats: (a) periodontitis (PD) progress with feeding of standard laboratory rat chow (STD) during ages 4–80 weeks; and (b) PD progress with feeding of a high sucrose-casein (H-SC) diet during young adulthood. Methods One group (N = 12) was euthanized at age 4 weeks (Baseline). Four groups (N = 8–16) consumed a STD diet from baseline and were necropsied at ages 22, 30, 52, and 80 weeks. Three groups (N= 10–16) consumed an H-SC diet from baseline. Two were necropsied at ages 22 and 30 weeks, respectively. The third switched to the STD diet at age 22 weeks and was necropsied at age 30 weeks. All mandibles/maxillae were assessed by histometry for degree of periodontal inflammation (PD Score), alveolar crest height (ACH, mm), and horizontal alveolar bone height (hABH, mm2). Results In STD diet rats aged ≥30 weeks, all endpoints were worse (P < 0.05) than at Baseline. In H-SC diet rats aged ≥22 weeks, all endpoints were worse than at Baseline (P < 0.05). At age 22 weeks, all endpoints were worse in the H-SC group than in the STD group (P < 0.05). By age 30 weeks, the STD and H-SC groups did not differ. Conclusions 1) STD diet fed rice rats develop moderate/severe PD by age 30 weeks; 2) an H-SC diet accelerates moderate/severe PD development; and 3) switching to a STD diet does not halt/reverse PD that was accelerated by an H-SC diet. These data further clarify use of the rice rat as a PD model.

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“…The use of rats offers economical advantages (23), availability of molecular tools, and access to genetic databanks (16,31). This model has been widely used in orthodontics (24), periodontics (25,32), conservative treatment of dental pulp (23), and studies of molecular mechanisms involved in teeth embryogenesis (16), but treatment strategies for immature teeth still have been investigated mainly in dogs (20)(21)(22)33).…”

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confidence: 99%

Response to Intracanal Medication in Immature Teeth with Pulp Necrosis: An Experimental Model in Rat Molars

Scarparo

Dondoni

Böttcher

et al. 2011

Journal of Endodontics

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Blockade of sympathetic β-receptors inhibits Porphyromonas gingivalis-induced alveolar bone loss in an experimental rat periodontitis model

Cited by 35 publications

References 30 publications

Periodontal Disease Is Associated with Insomnia among Victims of the Great East Japan Earthquake: A Panel Study Initiated Three Months after the Disaster

Periodontal Disease Is Associated with Insomnia among Victims of the Great East Japan Earthquake: A Panel Study Initiated Three Months after the Disaster

Age-related periodontitis and alveolar bone loss in rice rats

Response to Intracanal Medication in Immature Teeth with Pulp Necrosis: An Experimental Model in Rat Molars

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