Blockade of spontaneous and LH-induced ovulation in rats by indomethacin, an inhibitor of prostaglandin biosynthesis

Armstrong, David T.; Grinwich, Daniel L.

doi:10.1016/0090-6980(72)90062-7

Cited by 249 publications

(40 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Administration of PGF2a was shown to stimulate the release of LH in the rat and hamster (Saksena, Lau & Chang, 1974) and in the ewe (Carlson, Barcikowski & McCracken, 1973). Treatment with inhibitors of PG synthesis, indomethacin or aspirin, or with antiserum to PG was reported to block ovulation in rats, rabbits and mice (Armstrong & Grinwich, 1972;Orczyk & Behrman, 1972;Tsafriri, Lindner, Zor & Lamprecht, 1972;O'Grady, Caldwell, Auletta & Speroff, 1972;Lau et al, 1974a; (Ventura & Freund, 1973) and no information is available on the effects of inhibitors of PG synthesis on the seminal PG concentration in rats and mice. In both these species, spermatozoa are transported through the cervix into the uterine lumen immediately following ejaculation, while in women, sperma¬ tozoa move actively through the cervical mucus and their migration may be affected by PGs (Eskin et al, 1973).…”

Section: Discussionmentioning

confidence: 99%

Effect of Indomethacin on Blood Plasma Levels of Lh and Testosterone in Male Rats

Saksena¹,

Lau²,

Bartke³

et al. 1975

Reproduction

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Effect of Indomethacin on Blood Plasma Levels of Lh and Testosterone in Male Rats

Saksena¹,

Lau²,

Bartke³

et al. 1975

Reproduction

View full text Add to dashboard Cite

“…by indomethacin, hence the effect of LH is mediated by a prostaglandin (5,23,24). Similarly, we demonstrated that in porcine luteal tissue luteolysis involves activation of MMPs and TIMPs (11).…”

Section: Discussionmentioning

confidence: 82%

“…This activation can be prevented by indomethacin indicating that LH acts via prostaglandins (5). The two metalloproteases cleave collagen within the follicle thereby softening the follicular tissue which will finally result in the release of the oocytes.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, it is well documented that the process of ovulation also implicates increased LH-stimulated release of follicular collagenases (5,12,13). Since in rats the preovulatory LH surge causes ovulation and the preovulatory prolactin surge causes luteal regression of the corpora lutea formed during the previous ovulation, the effects of the preovulatory prolactin surge and the expression of collagenase genes was investigated.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Stimulation of matrix-metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 gene expression in rats by the preovulatory prolactin peak

Hirsch

Knoke²,

Leonhardt³

et al. 1999

European Journal of Endocrinology

View full text Add to dashboard Cite

Since structural luteolysis involves deterioration of tissue, the gene expression of matrix-metalloproteinase-1 (MMP-1) and the respective tissue inhibitor of this metalloprotease (TIMP-1) were measured at various times on the day of pro-oestrus and in animals in which the preovulatory prolactin surge was blocked for the duration of 3 cycles by bromocriptine. An additional group of prolactin-blocked rats received a prolactin replacement injection on the afternoon of pro-oestrus. In spontaneously pro-oestrous rats, MMP-1 and TIMP-1 gene expression increased significantly (P < 0.01) prior to the occurrence of the preovulatory LH surge but simultaneously with the onset of the preovulatory prolactin surge. When prolactin release was blocked by bromocriptine for 3 cycles, no such changes were observed during the afternoon of pro-oestrus. However, an intraperitoneal injection of bovine prolactin at the time when the preovulatory prolactin surge occurs normally, increased MMP-1 and TIMP-1 gene expression (P < 0.01). These results indicate that MMP-1 and TIMP-1 gene expression are stimulated by the preovulatory prolactin surge. Previous work has shown that the preovulatory LH surge activates the enzymatic cascade which leads to increased collagenase activity.

show abstract

“…Aspirin and indomethacin, inhibitors of PG biosynthesis, inhibits ovulation in rats (1)(2)(3), and levels of PGE and PGF in ovarian follicles were markedly increased immediately before ovulation in rats (4-6) and rabbits (7). It has been reported that luteinizing hormone (LH) and follicle stimulating hormone (FSH) in vitro have a stimulating action on PG biosynthesis in Graafian follicles before ovulation (8,9).…”

mentioning

confidence: 99%

Effect of gonadotropin and estrogen on changes in levels of prostaglandin in rat ovary.

1981

View full text Add to dashboard Cite

Abstract-Effects of gonadotropin and estrogen on the levels of pros taglandin (PG) in the rat ovary were investigated. PGF content in rat ovary, as measured by radioimmunoassay, was slightly higher than that by bioassay using rat stomach fundus, although there was no statistically significant difference.PGE and PGF levels in rat ovary during the estrous cycle were lowest on the day of diestrus, PGE was of the highest level on the day of estrus, and PGF on the day of proestrus.Both PGE and PGF were increased 24 hours after treatment with pregnant mare serum gonadotropin on the first day of diestrus.PGE was increased about 2.5 fold and PGF about 2.3 fold. PGF was significantly increased 24 hours after treament with estradiol on the first day of diestrus.These results suggest that gonadotropin may directly or indirectly regulate changes in ovarian PG content via actions of estrogen.

show abstract

Blockade of spontaneous and LH-induced ovulation in rats by indomethacin, an inhibitor of prostaglandin biosynthesis

Cited by 249 publications

References 11 publications

Effect of Indomethacin on Blood Plasma Levels of Lh and Testosterone in Male Rats

Effect of Indomethacin on Blood Plasma Levels of Lh and Testosterone in Male Rats

Stimulation of matrix-metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 gene expression in rats by the preovulatory prolactin peak

Effect of gonadotropin and estrogen on changes in levels of prostaglandin in rat ovary.

Contact Info

Product

Resources

About