Stimulation of matrix-metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 gene expression in rats by the preovulatory prolactin peak

Hirsch, Burkhard; Knoke, I.; Leonhardt, Sabine; Pitzel, L.; Jarry, Hubertus; Wuttke, W.

doi:10.1530/eje.0.1400583

Cited by 10 publications

(3 citation statements)

References 27 publications

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“…In rats, ovulation is also preceded by a Prl surge and the onset of this surge usually precedes the onset of the preovulatory LH surge by 2-4 h (Wuttke & Meites 1970, Butcher et al 1974, Hirsch et al 1993. The preovulatory Prl surge in rats has luteotrophic and luteolytic effects in that it causes augmentation of LH-induced luteinisation and associated increased P 4 secretion (Butcher et al 1972, Döhler & Wuttke 1974, Morishige & Rothchild 1974, as well as regression of old CLs (Malven & Sawyer 1966, Wuttke & Meites 1971) through stimulation of collagenases (Hirsch et al 1999). Blockage of the preovulatory Prl surge by dopaminergic agents in rats did not disturb oestrus cyclicity and ovulation (Döhler & Wuttke 1974), but did result in the accumulation of non-steroidogenic CLs (Wuttke & Meites 1971, Dö hler & Wuttke 1974.…”

Section: Discussionmentioning

confidence: 99%

Plasma concentrations of prolactin in brushtail possums (Trichosurus vulpecula) in different physiological states

Crawford

Thomson

Beaumont

et al. 2006

Journal of Endocrinology

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Prolactin (Prl) has been implicated in reproduction in many mammalian species and is illustrated by the distinctive patterns of secretion during the breeding season, the oestrous cycle and lactation. The recent development of a homologous RIA for measuring the circulating Prl concentrations in brushtail possums has facilitated the reliable measurement of Prl in plasma during different physiological states in this species for the first time. Determination of Prl concentrations during lactation involved the collection of weekly blood samples from eight female possums from the time of parturition through either one or two consecutive lactational cycles. Prl was at baseline levels during early lactation (weeks 0-14 post-partum), and then increased markedly to maximum concentrations at weeks 19-21 before returning to nadir levels at a time coincident with the weaning of pouch young (weeks 23-27). The profile of Prl secretion over the oestrous cycle and in particular at the time of the preovulatory LH surge was obtained from 14 possums during the reproductive cycle, in which preovulatory follicle development and ovulation were monitored by laparoscopy. There was no distinct daily pattern of Prl secretion during the oestrous cycle; however, in 3/4 possums in which a typical preovulatory LH surge was measured, a biphasic preovulatory Prl surge was also observed. The preovulatory Prl surge commenced 2-6 h prior to, and had returned to baseline close to the onset of, the preovulatory LH surge, and a second surge of Prl occurred concomitantly with the delayed preovulatory FSH surge. Seasonality of Prl levels was established from weekly blood samples collected from six barren female possums, and concentrations of Prl were lower during the breeding season compared to the non-breeding season. Additionally, a circadian pattern of Prl secretion was evident in both female and male possums, with Prl levels higher in the morning compared to the afternoon. In conclusion, interpretation of endogenous secretory patterns suggests that Prl may be important during late lactation and at impending ovulation, but the involvement of the circannual rhythm of Prl in the regulation of seasonality in the brushtail possum remains to be determined.

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Section: Discussionmentioning

confidence: 99%

Plasma concentrations of prolactin in brushtail possums (Trichosurus vulpecula) in different physiological states

Crawford

Thomson

Beaumont

et al. 2006

Journal of Endocrinology

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“…PRL also alters calcium transport across the plasma membrane [28,29] and has been shown to affect protein synthesis via a calciumdependent system in the corpus luteum [30]. Additional destruction of tissue, in this case extracellular matrix, may be carried out via matrix metalloproteinases, which have been reported to increase in the corpus luteum following PRL treatment to induce luteal regression [31,32], and to be associated with a depletion of protein from the tissue [31].…”

Section: Discussionmentioning

confidence: 99%

Repeated Exposure to Prolactin Is Required to Induce Luteal Regression in the Hypophysectomized Rat1

Bowen¹,

Keyes²

2000

Biology of Reproduction

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We investigated whether prolactin (PRL) treatments resembling the intermittent PRL surges of estrous cycles could induce luteal regression in hypophysectomized rats. Immature female rats were stimulated to ovulate and form corpora lutea with exogenous gonadotropins, and were hypophysectomized following ovulation. A single s.c. injection of either vehicle (VEH) or PRL was administered to each rat on post-hypophysectomy Day 8 and again on Day 11. The four resulting treatment groups consisted of rats that received two injections of VEH, VEH followed by PRL, PRL followed by VEH, or two injections of PRL. Rats were killed 24 or 72 h following the second injection. Plasma 20alpha-dihydroprogesterone, luteal weight, and total luteal protein were determined. One ovary was sectioned for immunohistochemistry for monocytes/macrophages, apoptotic nuclei, and major histocompatibility class II (MHC II) molecules. No effect of time (following injection) was observed on any endpoint, indicating that PRL does not have an ongoing regressive action. Time groups from within each treatment group were therefore pooled for analysis. Significant declines (P: < 0.05) in plasma concentrations of 20alpha-dihydroprogesterone, luteal weight, and protein per corpus luteum occurred only after two injections of PRL. Numbers of luteal monocytes/macrophages, apoptotic nuclei, and MHC II-positive cells were low in all groups; numbers of luteal monocytes/macrophages increased following two injections of PRL (P: < 0.05). We conclude that PRL has a cumulative regressive effect on the corpus luteum of the hypophysectomized rat. Drawing a parallel with the estrous cycle, we suggest that continued exposure to PRL, over several cycles, is necessary to induce full luteal regression.

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“…Prolactin is reported to regulate protein synthesis in animal salivary glands (Sabbadini and Berczi, 1995). In addition, several investigators have reported that prolactin may induce the overexpression of proteinases in the synovial cells of patients with rheumatoid arthritis (Nagafuchi et al, 1999) or during preovulatory peaks (Goto et al, 1999;Hirsch et al, 1999), ie, in a strong prolactin environment. Lastly, Azuma et al (1997) have reported an excessive metalloproteinase-2 production by human salivary gland acinar cells in response to cytokines.…”

Section: Steinfeld Et Almentioning

confidence: 99%

Prolactin Up-Regulates Cathepsin B and D Expression in Minor Salivary Glands of Patients with Sjögren's Syndrome

Steinfeld

Maho

Chaboteaux

et al. 2000

Laboratory Investigation

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SUMMARY:Various proteases are expressed in the minor salivary glands (MSG) of patients with Sjögren's syndrome (SS), and as we have already shown, prolactin is neosynthesized in the acinar cells of patients with SS. The present study aims to characterize the influence of PRL on the expression of cathepsin B and D in the MSG of patients with SS. Cathepsin B and D expression was investigated immunohistochemically in MSG of 30 patients with SS and 15 healthy volunteers. The presence of cathepsin B and D mRNAs was checked in three SS patients and three control subjects by means of reverse transcriptionpolymerase chain reaction (RT-PCR). The specificity of the anti-cathepsin B and D antibodies used for the immunohistochemistry was checked by means of western blotting analysis. The influence of prolactin on the immunohistochemical expression of cathepsin B and D was quantitatively assayed by computer-assisted microscopy at three different doses (5, 50, and 500 ng/ml) on eight MSGs (four control subjects and four patients with SS) maintained ex vivo under organotypic cultures. This influence was also investigated at the mRNA level. Whereas cathepsin B immunopositivity was absent from glandular epithelial cells of healthy subjects and only slightly present in SS patients, cathepsin D immunoreactivity was considerably greater (p Ͻ 0.0001) in both the acini and the ducts of patients with SS as compared with control subjects. Cathepsin B, but not D, was also expressed in about 20% of infiltrating mononuclear cells of SS patients. Treatment of both healthy and SS minor salivary glands with PRL significantly (p Ͻ 0.05 to p Ͻ 0.0001) enhanced cathepsin B and D expression in acinar and ductal cells at both protein and mRNA levels. PRL produced locally in MSGs of SS patients, but not those of healthy subjects, could play a role in the pathogenesis of Sjögren's syndrome, if only through the activation of proteolytic activity on the part of cathepsins B and D. (Lab Invest 2000, 80:1711-1720.

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Stimulation of matrix-metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 gene expression in rats by the preovulatory prolactin peak

Cited by 10 publications

References 27 publications

Plasma concentrations of prolactin in brushtail possums (Trichosurus vulpecula) in different physiological states

Plasma concentrations of prolactin in brushtail possums (Trichosurus vulpecula) in different physiological states

Repeated Exposure to Prolactin Is Required to Induce Luteal Regression in the Hypophysectomized Rat1

Prolactin Up-Regulates Cathepsin B and D Expression in Minor Salivary Glands of Patients with Sjögren's Syndrome

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