Blockade of kit signaling induces transdifferentiation of interstitial cells of Cajal to a smooth muscle phenotype

Torihashi, Shigeko; Nishi, Katsuhide; Tokutomi, Yoshiko; Nishi, Tetsuo; Ward, Sean M.; Sanders, Kenton M.

doi:10.1016/s0016-5085(99)70560-3

Cited by 262 publications

(237 citation statements)

References 23 publications

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“…5). Inactivation of c-Kit by injection of the neutralizing antibody ACK2 in the mouse resulted in distension of the stomach, small intestine, and colon, and, therefore, the size of the GI tract in Sparse mutants was compared to wild0type larvae (Maeda et al, 1992;Torihashi et al, 1999). Sparse and wildtype larvae were incubated for 1 hr in media containing FITC-labeled dextran, anesthetized, and washed.…”

Section: Resultsmentioning

confidence: 99%

Kit‐like immunoreactivity in the zebrafish gastrointestinal tract reveals putative ICC

Rich

Leddon

Hess

et al. 2007

Developmental Dynamics

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Section: Resultsmentioning

confidence: 99%

Kit‐like immunoreactivity in the zebrafish gastrointestinal tract reveals putative ICC

Rich

Leddon

Hess

et al. 2007

Developmental Dynamics

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“…(Brading AF et al 2005). Torihashi et al (Torihashi S et al 1999) reported that when c-kit receptors were blocked during development, the ICCs almost entirely disappeared from the small intestine. However, this loss of ICCs was not accounted for using assays for cell death, and closer examination revealed that the remaining ICCs developed ultrastructural features similar to those of smooth muscle cells.…”

Section: Congenital Primary Obstructive Megauretermentioning

confidence: 99%

Pacemakers in the upper urinary tract

Benedetto

Arena

Nicòtina

et al. 2012

Neurourology and Urodynamics

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BackgroundPacemakers in upper urinary tract (UUT) are still under study.AimWe reviewed the role of some cells that seem to be involved in the propulsion of urinary bolus from UUT to the bladder. Materials & MethodsWe focuses on evaluating studies on the mechanisms by which the UUT propels urine to the bladder via pacemaker cells.ResultsElectric active pacemaker cells generate pyeloureteric autorhythmicity driving adjacent smooth muscle cells (SMCs); it emphasizes the role of the interstitial cells of Cajal‐like cells (ICC‐LCs) localized in the UUT. Interstitial cells of Cajal (ICCs) are now thought to cooperate in conducting and amplifying pacemaker activity in the UUT. These cells produce electrical slow‐wave potentials and determine the propagation of peristaltic activity. Identification of ICC‐LCs is facilitated by use of c‐kit antibodies. Contraction waves arising from the UUT and the propagation of these waves may require the direct involvement of ICC‐LCs, as c‐kit immunoreactivity appears developmentally at the same time as coordinated unidirectional peristaltic contraction. ICC‐LCs observed in the UUT have morphological features similar to those of c‐kitpositive ICCs in the gastrointestinal tract. In addition to gastrointestinal motility, ICCs may also play a significant role in the propagation, coordination, and modulation of ureteropelvic peristalsis.DiscussionAlterations in ICC‐LCs are closely associated with a variety of motility disorders and many congenital urological diseases of the UUT such as primary obstructive megaureter, congenital ureteropelvic junction obstruction, and vesicoureteral reflux.ConclusionThese observations open the way for further investigations of this cell type. Neurourol. Urodynam. 32: 349–353, 2013. © 2012 Wiley Periodicals, Inc.

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“…furthermore, strong evidence that gastric cancer originates from mesenchymal stem cells (MSCs), bone-marrow-derived sources and transformation of stem cells was noted in the human stomach (21). In the GI tract, ICC, one type of MSCs, express c-Kit and its alterations are reported to induce a change in their cell type (22). furthermore, tumor growth is also dependent on the tyrosine kinase c-Kit product (CD117).…”

Section: Interstitial Cells Of Cajal (Icc)-like-c-kit Positive Cells mentioning

confidence: 99%

“…however, no gastric mucosal cells except mast cells are reported to have c-Kit expression (23). In fact, ICC are also present in the submucosal plexus, muscularis mucosa and mucosa (1,(22)(23)(24)(25).…”

Section: Interstitial Cells Of Cajal (Icc)-like-c-kit Positive Cells mentioning

confidence: 99%

Interstitial cells of Cajal (ICC)-like-c-Kit positive cells are involved in gastritis and carcinogenesis in human stomach

Kim¹

2011

Oncol Rep

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Dense fusiform cell bodies with many processes were found in each layer. We also studied the c-Kit-positive immunoreactivity distribution pattern in the mucosa. c-Kit (+) cells were found mainly around the epithelial repair zone of the normal gastric fundus/corpus and of the fundus/corpus with non-metaplastic chronic gastritis. Notably, they were found attached to the epithelia of the repair zone in non-metaplastic chronic gastritis. In chronic gastritis with intestinal metaplasia, they were found scattered everywhere in the stroma of the gastric mucosa and did not attach to the metaplastic epithelium. We found c-Kit (+) ICC-like cells in human mucosa. They were present mainly in the stroma around the repair zone of the glands in chronic gastritis as well as in normal mucosa, whereas they seemed to redistribute over the whole mucosa in gastritis with intestinal metaplasia. These cells around the repair zone were found to be tightly attached to epithelial cells, but not to metaplastic epithelial cells. Thus, c-Kit (+) Icc-like cells appear to have a role in the epithelial recovery process and may be associated with carcinogenesis of human gastric mucosa.

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Blockade of kit signaling induces transdifferentiation of interstitial cells of Cajal to a smooth muscle phenotype

Cited by 262 publications

References 23 publications

Kit‐like immunoreactivity in the zebrafish gastrointestinal tract reveals putative ICC

Kit‐like immunoreactivity in the zebrafish gastrointestinal tract reveals putative ICC

Pacemakers in the upper urinary tract

Interstitial cells of Cajal (ICC)-like-c-Kit positive cells are involved in gastritis and carcinogenesis in human stomach

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