Block of Peripheral Pain Response by High-Frequency Sinusoidal Stimulation

Wodlinger, Brian; Rashid, Saifur; Durand, Dominique M.

doi:10.1111/ner.12011

Cited by 6 publications

(2 citation statements)

References 23 publications

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“…Unfortunately, the most common term, “high‐frequency alternating current,” is ambiguous and has resulted in some confusion in the literature. Frequencies as low as 130 Hz have been termed high frequency . It is important to properly distinguish the specific parameters used for KHFAC block because the characteristic effects on the nerve vary considerably as a function of frequency, amplitude, and electrode design (and possibly other factors as well).…”

Section: Introductionmentioning

confidence: 99%

Reversible Nerve Conduction Block Using Kilohertz Frequency Alternating Current

Kilgore

Bhadra

2014

Neuromodulation: Technology at the Neural Interface

209

231

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Objectives The features and clinical applications of balanced-charge kilohertz frequency alternating currents (KHFAC) are reviewed. Preclinical studies of KHFAC block have demonstrated that it can produce an extremely rapid and reversible block of nerve conduction. Recent systematic analysis and experimentation utilizing KHFAC block has resulted in a significant increase in interest in KHFAC block, both scientifically and clinically. Materials and Methods We review the history and characteristics of KHFAC block, the methods used to investigate this type of block, the experimental evaluation of block, and the electrical parameters and electrode designs needed to achieve successful block. We then analyze the existing clinical applications of high frequency currents, comparing the early results with the known features of KHFAC block. Results Although many features of KHFAC block have been characterized, there is still much that is unknown regarding the response of neural structures to rapidly fluctuating electrical fields. The clinical reports to date do not provide sufficient information to properly evaluate the mechanisms that result in successful or unsuccessful treatment. Conclusions KHFAC nerve block has significant potential as a means of controlling nerve activity for the purpose of treating disease. However, early clinical studies in the use of high frequency currents for the treatment of pain have not been designed to elucidate mechanisms or allow direct comparisons to preclinical data. We strongly encourage the careful reporting of the parameters utilized in these clinical studies, as well as the development of outcome measures that could illuminate the mechanisms of this modality.

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Section: Introductionmentioning

confidence: 99%

Reversible Nerve Conduction Block Using Kilohertz Frequency Alternating Current

Kilgore

Bhadra

2014

Neuromodulation: Technology at the Neural Interface

209

231

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show abstract

“…This sentinel work demonstrates the feasibility of such recordings from epidurally placed SCS electrodes in patients and their use as potential sources of feedback information for future SCS systems. The potential of paresthetic‐free SCS is discussed in articles on high frequency (10 kHz) and burst stimulation . These articles provide some basic rationale for the use of these different stimulation parameters for more effective SCS‐induced pain relief as well as preliminary clinical results.…”

Section: Scs Technology: 2013 and Beyondmentioning

confidence: 99%

Progress in the Technology of Neuromodulation: The Emperor’s New Clothes?

Levy¹

2013

Neuromodulation: Technology at the Neural Interface

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Implantable neurotechnologies: electrical stimulation and applications

Nag

Thakor

2016

Med Biol Eng Comput

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Neural stimulation using injected electrical charge is widely used both in functional therapies and as an experimental tool for neuroscience applications. Electrical pulses can induce excitation of targeted neural pathways that aid in the treatment of neural disorders or dysfunction of the central and peripheral nervous system. In this review, we summarize the recent trends in the field of electrical stimulation for therapeutic interventions of nervous system disorders, such as for the restoration of brain, eye, ear, spinal cord, nerve and muscle function. Neural prosthetic applications are discussed, and functional electrical stimulation parameters for treating such disorders are reviewed. Important considerations for implantable packaging and enhancing device reliability are also discussed. Neural stimulators are expected to play a profound role in implantable neural devices that treat disorders and help restore functions in injured or disabled nervous system.

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Block of Peripheral Pain Response by High-Frequency Sinusoidal Stimulation

Cited by 6 publications

References 23 publications

Reversible Nerve Conduction Block Using Kilohertz Frequency Alternating Current

Reversible Nerve Conduction Block Using Kilohertz Frequency Alternating Current

Progress in the Technology of Neuromodulation: The Emperor’s New Clothes?

Implantable neurotechnologies: electrical stimulation and applications

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