Block of delayed rectifier potassium current, IK, by terfenadine in cat ventricular myocytes

Chen, Yiwang; Gillis, Richard A.; Woosley, Raymond L.

doi:10.1016/0735-1097(91)91526-k

Cited by 6 publications

(3 citation statements)

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“…None of the reports of headache was attributed to the study drug. Pharyngitis was reported by 10.0% (14/140) of the cetirizine patients and 13.0% (9/69) of the placebo patients. Abdominal pain was reported by 9.3% (13/140) of the cetirizine patients and 4.3% (3/69) of the patients given a placebo.…”

Section: Percentage Of Change In Hodges ' Qtcmentioning

confidence: 99%

Absence of QT_cProlongation with Cetirizine in Children Aged 6 to 11 Years

Winder¹,

Noonan²,

Lumry³

et al. 1996

Pediatric Asthma, Allergy & Immunology

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Background: In previous clinical trials, cetirizine has been shown to be efficacious in the treatment of seasonal allergic rhinitis (SAR), perennial allergic rhinitis, and chronic idiopathic urticaria when given once daily. As significant QT prolongation and cardiac arrhythmias have been reported with some of the newer antihistamines, the electrocardiographic effects of cetirizine were evaluated. A previous study in normal, healthy, adult volunteers had demonstrated that cetirizine does not prolong the QT interval at up to six

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Section: Percentage Of Change In Hodges ' Qtcmentioning

confidence: 99%

Absence of QT_cProlongation with Cetirizine in Children Aged 6 to 11 Years

Winder¹,

Noonan²,

Lumry³

et al. 1996

Pediatric Asthma, Allergy & Immunology

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“…As shown in in vitro studies, the calcium channel antagonist bepridil, erythromycin, and the histamine type 1 antagonists astemizole and terfenadine cause QT, interval prolongation by inhibiting the efflux of potassium during phase 3 of the action p~tential.~'. 42 Prenylamine, another calcium channel blocker, causes this syndrome by stimulating the influx of calcium during phase 2 of the action potential,43 Although unproved in humans, i t is feasible that the effect of haloperidol at one of these ion channels may also be important in prolonging the QT, interval.…”

Section: Cardiovascular and Ecg Effects Of Antipsychoticsmentioning

confidence: 99%

Conduction Disturbances Associated with Administration of Butyrophenone Antipsychotics in the Critically Ill: A Review of the Literature

Lawrence,

Nasraway

1997

Pharmacotherapy

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Droperidol and haloperidol have demonstrated efficacy and safety in the treatment of acute delirium in critically ill patients. We conducted MEDLINE and manual searches of literature published from 1966–1996 to identify articles describing conduction disturbances associated with the drugs. The objectives were to describe the proposed mechanisms of acquired long QTc interval syndrome and torsades de pointes, and to recommend how critically ill patients receiving these agents should be monitored. We found 11 published reports of conduction disturbances associated with intravenous administration of droperidol or haloperidol. The majority of cases occurred in critically ill patients prescribed more than 50 mg/24 hours of either agent. Of the 18 patients described, 13 (72%) had a history of cardiovascular disease. Based on the small number of available case reports, it seems reasonable to suggest that the incidence of adverse cardiovascular effects due to droperidol and haloperidol is small. The mechanism of butyrophenone‐induced QTc interval prolongation is not known, but is presumed to involve abnormal ventricular repolarization and the development of early after‐depolarizations. Before initiating therapy with droperidol or haloperidol in critically ill patients, a baseline QTc interval and serum magnesium and potassium concentrations should be measured. If the baseline QTc interval is 440 msec or longer, and they are receiving other drugs that may prolong the QTc interval or they have electrolyte disturbances, a butyrophenone antipsychotic should be prescribed with caution. All critically ill patients receiving droperidol or haloperidol should undergo electrocardiogram monitoring and QTc interval measurement; special attention should be given to those receiving doses greater than 50 mg/24 hours, as these patients appear to be at greatest risk for development of conduction disturbances. Based on the currently available literature, in any critically ill patient receiving droperidol or haloperidol therapy whose QTc interval lengthens by 25% or more over baseline, therapy should be discontinued or the dosage reduced.

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“…H1-Antagonist have been widely used for the treatment of rhinitis for nearly 50 years (4,5). Prophylactic Fexofenadine, a non-sedating, highly selective antagonist shows more promising activity with mild side effects at proper dosage schedule (6)(7)(8)(9)(10). This paper reports the results of a clinical trial ofFexofenadine as prophylactic treatment in allergic rhinitis.…”

Section: Introductionmentioning

confidence: 99%

Fxofenadine: Prophylactic Treatment in Allergic Rhinitis

Lone¹,

Lone²,

Sayeed³

et al. 2017

IOSR JDMS

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Allergic rhinitis is commonly found in Kashmir. Prophylactic Fexofenadine shows more promising activity with mild side effects at proper dosage schedule. 10 cases of Allergic Rhinitis were studied during a period from Jan 2013 to July 2015.Clinical symptomatology of Allergic rhinitis are described as recurrent ,episodic profuse mucoid nasal discharge, excessive sneezing and nasal obstruction. The associated symptoms being itching and burning sensation of conjunctiva, nasal mucosa and Oropharynx and the aggravation of the symptoms coincident with the pollination. The prophylactic treatment with Fexofenadine 120 mg once daily for 3 weeks with 1 week drug wash-out interval in a month has proven very effective in preventing the acute attack of allergic rhinitis. The drug has been tried for such a prolonged time and is virtually free of side effects and toxicity (clinically) on such dosage.

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Block of delayed rectifier potassium current, IK, by terfenadine in cat ventricular myocytes

Cited by 6 publications

References 0 publications

Absence of QT_cProlongation with Cetirizine in Children Aged 6 to 11 Years

Absence of QT_cProlongation with Cetirizine in Children Aged 6 to 11 Years

Conduction Disturbances Associated with Administration of Butyrophenone Antipsychotics in the Critically Ill: A Review of the Literature

Fxofenadine: Prophylactic Treatment in Allergic Rhinitis

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Block of delayed rectifier potassium current, IK, by terfenadine in cat ventricular myocytes

Cited by 6 publications

References 0 publications

Absence of QTcProlongation with Cetirizine in Children Aged 6 to 11 Years

Absence of QTcProlongation with Cetirizine in Children Aged 6 to 11 Years

Conduction Disturbances Associated with Administration of Butyrophenone Antipsychotics in the Critically Ill: A Review of the Literature

Fxofenadine: Prophylactic Treatment in Allergic Rhinitis

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Product

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Absence of QT_cProlongation with Cetirizine in Children Aged 6 to 11 Years

Absence of QT_cProlongation with Cetirizine in Children Aged 6 to 11 Years