Block copolymer micelles for drug delivery: design, characterization and biological significance

Kataoka, Kazunori; Harada, Atsushi; Nagasaki, Yukio

doi:10.1016/s0169-409x(00)00124-1

Cited by 3,109 publications

(1,983 citation statements)

References 76 publications

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“…Polymeric micelles are nanoscopic structures formed by self-assembly of amphiphilic polymers in water above the critical micelle concentration (CMC, Kataoka et al, 2001). Micellar shells are formed by hydrophilic blocks that are exposed to aqueous medium, micellar shells facilitate the solubilisation of amphiphile in water and thus stabilise aggregates.…”

Section: Figmentioning

confidence: 99%

Interaction of Nanoparticles in Biological Systems and their Role in Therapeutical Treatment of Tuberculosis and Cancer

Meena¹,

Singh²,

Sahare³

et al. 2014

JLA

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The kind of interactions which nanoparticles show in the biological systems is very interesting. Nanoparticles (NPs) on entering the living system immediately come in contact with proteins which serve many applications of nanoparticles including bio-signalling, therapeutics and drug delivery systems. Moreover, many inorganic oxide nanoparticles can also serve the purpose of antibacterial/antiviral by assisting in the production of reactive oxygen species (ROS). The role of nanoparticles in therapeutics is very significant and increasing day-by-day as it assures better treatment to the patient by enhancing activity of drug, improving bioavailability, flexibility in deciding route of administration and long term stability of drug resulting in better treatments of diseases. NPs such as solid lipid NPs, polymeric NPs, porous NPs, liposomes are being used for treatment of various types of diseases. Numerous carriers based drug delivery systems incorporating anti-TB drugs have been developed for target site actions. NPs encapsulating anti-cancer drugs such as doxorubicin, paclitaxel have also been developed for treatment of different types of cancers. Results of these studies give hopes to the researchers for the use of nanoparticles in the field of therapeutics. The NPs can be toxic as well as nontoxic to the biological system. Therefore, some adverse effects, such as, cytotoxicity on inhaling some kinds of nanoparticles must be kept in mind for judicious use of such systems during synthesis or during handling. The paper describes recent developments in the field by reviewing the available literature.

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Section: Figmentioning

confidence: 99%

Interaction of Nanoparticles in Biological Systems and their Role in Therapeutical Treatment of Tuberculosis and Cancer

Meena¹,

Singh²,

Sahare³

et al. 2014

JLA

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“…In a salt effect study, the release rate and diffusion coefficient of propranolol, a model drug, were significantly reduced when NaCl, Na 2 SO 4 , NaH 2 PO 4 , MgSO 4 and CaCl 2 were added to the gels of 21 % Poloxamer 407 in an aqueous medium at 37 °C through a cellulose membrane, as presented in Figure 4. The magnitude of the effect on release rate depends on the nature and concentration of the salt.…”

Section: Effect Of Additives On the Delivery Of Small Molecules From mentioning

confidence: 99%

“…Polymeric micelles are nanoscopic (> 100 nm) structures formed by amphiphilic block copolymers composed of hydrophilic and hydrophobic chains that selfassemble in water, above a certain concentration named the critical micelle concentration (CMC) [1,4]. Micelles comprise of an inner and outer domain referred to as core and shell, respectively.…”

Section: Introductionmentioning

confidence: 99%

Poly(ethylene oxide)–Poly(propylene oxide)-Based Copolymers for Transdermal Drug Delivery: An Overview

Yapar¹,

Ýnal²

2013

Trop. J. Pharm Res

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“…Polymeric micelles are another type of nanomaterial that have attracted considerable attention as carriers for drug delivery (Kataoka et al 2001;Kabanov and Alakhov 2002;Kwon 2003;Allen and Cullis 2004;Torchilin 2004;Aliabadi and Lavasanifar 2006) and diagnostic imaging agents (Torchilin 2002). These micelles form spontaneously in aqueous solutions of amphiphilic block copolymers and have core-shell architecture.…”

Section: Nanomaterials For Drug Delivery Across the Blood-brain Barriermentioning

confidence: 99%

Novel Nanomaterials for Clinical Neuroscience

Gilmore

Xiang

Quan

et al. 2008

J Neuroimmune Pharmacol

206

123

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Neurodegenerative disorders including Alzheimer's and Parkinson's diseases, amyotrophic lateral sclerosis, and stroke are rapidly increasing as population ages. The field of nanomedicine is rapidly expanding and promises revolutionary advances to the diagnosis and treatment of devastating human diseases. This paper provides an overview of novel nanomaterials that have potential to improve diagnosis and therapy of neurodegenerative disorders. Examples include liposomes, nanoparticles, polymeric micelles, block ionomer complexes, nanogels, and dendrimers that have been tested clinically or in experimental models for delivery of drugs, genes, and imaging agents. More recently discovered nanotubes and nanofibers are evaluated as promising scaffolds for neuroregeneration. Novel experimental neuroprotective strategies also include nanomaterials, such as fullerenes, which have antioxidant properties to eliminate reactive oxygen species in the brain to mitigate oxidative stress. Novel technologies to enable these materials to cross the blood brain barrier will allow efficient systemic delivery of therapeutic and diagnostic agents to the brain. Furthermore, by combining such nanomaterials with cell-based delivery strategies, the outcomes of neurodegenerative disorders can be greatly improved.

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Block copolymer micelles for drug delivery: design, characterization and biological significance

Cited by 3,109 publications

References 76 publications

Interaction of Nanoparticles in Biological Systems and their Role in Therapeutical Treatment of Tuberculosis and Cancer

Interaction of Nanoparticles in Biological Systems and their Role in Therapeutical Treatment of Tuberculosis and Cancer

Poly(ethylene oxide)–Poly(propylene oxide)-Based Copolymers for Transdermal Drug Delivery: An Overview

Novel Nanomaterials for Clinical Neuroscience

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