BLOATED IRRITABLE BOWEL SYNDROME DEFINED BY DYNAMIC 99mTc BRAN SCAN

Trotman, I F; Price, ClareC.

doi:10.1016/s0140-6736(86)90053-x

Cited by 46 publications

(18 citation statements)

References 5 publications

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“…However, in a study comparing 10 women with the irritable bowel syndrome and bloating with 8 normal controls, ileocaecal motility was monitored using orally ingested technetium-99m bran (Trotman and Price 1986). In all except one control subject the bran accumulated in the terminal ileum by 3 h after ingestion.…”

Section: Small Bowelmentioning

confidence: 99%

“…Provided the radioisotope is bound to a non-absorbable substance, it usually accumulates in the terminal ileum. A subsequent meal will then cause the terminal ileum to propel food into the caecum (Trotman and Price 1986). Furthermore, small variations in the time taken for food to reach the caecum (for example 2~4 h) are of little significance when considered in the context 168 Time (h) Fig.…”

Section: Delivering Radioisotope To the Small Bowel And Colonmentioning

confidence: 99%

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The small intestine and colon: scintigraphic quantitation of motility in health and disease

Kamm

1992

Eur J Nucl Med

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Radioisotopes allow accurate quantitation of the pattern and effectiveness of the transit of chyme through the small and large intestines. Abnormalities of small bowel transit can be demonstrated in patients with the irritable bowel syndrome, and patients with chronic idiopathic intestinal pseudo-obstruction due to either a visceral myopathy or neuropathy. In the colon, radioisotopic studies of transit have demonstrated the site of delayed transit in some severely constipated patients. In patients with these disorders of transit, functional studies may influence the choice of medical or surgical therapy although there are few prospective studies which have established their worth in this context. Radioisotope studies can also be utilised to study the effectiveness of delivery of drugs to the small and large bowel, and to study the adequacy of rectal evacuation in patients with a defaecatory disturbance. The low radiation dose and possibility of frequent observations make radioisotope studies valuable for clinical and research studies in functional gastrointestinal disorders.

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Section: Small Bowelmentioning

confidence: 99%

Section: Delivering Radioisotope To the Small Bowel And Colonmentioning

confidence: 99%

The small intestine and colon: scintigraphic quantitation of motility in health and disease

Kamm

1992

Eur J Nucl Med

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“…Pain in IBS can be reproduced by inflating balloons in the small intestine (Moriarty & Dawson, 1982), and patients with IBS have been shown to have selective dysfunction of mechano-sensitive small intestinal afferents (Accarino et al 1995). Impaired ileo-caecal valve function in patients with IBS presenting with right-sided abdominal pain and bloating has also been demonstrated (Trotman & Price, 1986).…”

Section: Midgut Dysmotilitymentioning

confidence: 99%

Chronic idiopathic intestinal pseudo-obstruction: the need for a multidisciplinary approach to management

Silk

2004

Proc. Nutr. Soc.

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At the outset of the research programme into irritable bowel syndrome (IBS) it was perceived that there was a need to develop a symptom-based classification for the patients. Four groups of patients were identified, those with spastic colon syndrome, diarrhoea-predominant spastic colon syndrome, functional diarrhoea and midgut dysmotility. While working with outpatients with IBS it was noted how some of them had suffered symptoms for many years; specifically, a group of patients satisfying the criteria for midgut dysmotility had also suffered from particularly severe and intractable intestinal symptoms. These patients underwent 24 h ambulatory studies of small intestinal motility and the majority were found to have manometric features of chronic idiopathic intestinal pseudo-obstruction (CIIP). To characterise the cause, laparoscopic full-thickness small intestine and colonic biopsies have been obtained in forty-five of the latter group of patients. Of these patients 58% have been found to have complete or partial deficiency of a-actin epitope staining in the inner circular layer of small intestinal smooth muscle. This deficiency is believed to represent an important biomarker rather than the cause of CIIP, since a-actin epitope deficiency has been observed in association with enteric neuropathy and myopathies. In relation to the management of CIIP patients, a multidisciplinary model is proposed incorporating management of co-morbid psychological and psychiatric pathology, abdominal and musculoskeletal pain, fatigue, urological symptoms and nutrition. A six-stage nutritional management plan for these patients is presented.Chronic idiopathic intestinal pseudo-obstruction: Irritable bowel syndrome:Symptom-based classification: Multidisciplinary management model: Nutritional management plan

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“…While whole gut transit is normal in IBS patients and accelerated in diarrhoeapredominant ones 70 , it was also suggested that ileo-colonic transit was delayed in patients complaining of bloating. 71 …”

Section: Abnormal Intestinal Motility Patternsmentioning

confidence: 99%

Alterations of sensori-motor functions of the digestive tract in the pathophysiology of irritable bowel syndrome

Delvaux¹

2004

Best Practice & Research Clinical Gastroenterology

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BLOATED IRRITABLE BOWEL SYNDROME DEFINED BY DYNAMIC 99mTc BRAN SCAN

Cited by 46 publications

References 5 publications

The small intestine and colon: scintigraphic quantitation of motility in health and disease

The small intestine and colon: scintigraphic quantitation of motility in health and disease

Chronic idiopathic intestinal pseudo-obstruction: the need for a multidisciplinary approach to management

Alterations of sensori-motor functions of the digestive tract in the pathophysiology of irritable bowel syndrome

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