Bleomycin: An Effective Treatment for Warts

Abstract

Intrale.sional infection of bleomycin sulphate i.s a safe and almost completely effective treatment for warts. One tfiousand and fifty-two warts were injected with bleomycin .sulphate, re.sulting in a cure rate of 99.23% after 12 weeks. No systemic manife.station.s of hleomycin toxicity were observed during the trial. After failure of injection of saline, it would appear that it is the cytotoxic effeet of bleomycin and not the physical interference with ihe wart that effects the ctire.

Dermatology in the military: an East Timor study

“…Pain can be severe and debilitating. Various treatment modalities have been described including cryotherapy, 22 cautery, 22 carbon dioxide laser, 23 intralesional bleomycin, 24 surgery, 25 radiotherapy, 25 and topical therapy 26 . In an operational setting with limited resources, Upton's paste (Trichloroacetic acid one part, salicylic acid six parts, glycerol two parts) proved cost‐effective and efficient in treating both plane and plantar warts.…”

Raynaud's phenomenon of a single digit following local intradermal bleomycin sulfate injection

“…bleomycin therapy has been associated with a number of varied skin reactions, including hyperpigmentation, sclerosis, gangrene, indurated plaques, and hyperpigmented nodules (6). Several recent reports have described the use of intralesional injections of bleomycin sulfate for treatment of cutaneous warts, and have noted no complications (7)(8)(9)(10). We describe a patient who received this treatment and subsequently developed Raynaud's phenomenon, which was limited to the injected digit.…”

Treatment of oral leukoplakia with topical bleomycin. A pilot study

“…Intralesional bleomycin has shown an overall cure rate in the study of the treatment of warts. 24 Bleomycin with iontophoresis has been studied in the treatment of leukoplakia and papillomas of the head and neck region.25 This method of application was not effective for malignant lesions, but was effective at removing leukoplakia of the oral mucosa. A single case of the complete resolution of hyperkeratotic leukoplakia with atypia using local injections of 5 mg of bleomycin weekly in eight treatments has been reported.…”