Blend composition effect on the diameter of electrospun chitosan (CHT)/poly(ethylene oxide) (PEO) nanofibers

Scheidt, Desirée Tamara; Pellá, Michelly Cristina Galdioli; Breitenbach, Gabriela Lauer; Simões, Márcia Regina; Caetano, Josiane; Martins, Cleide Viviane Buzanello; Rossin, Ariane R. de S.; Muniz, Edvani C.; Dragunski, Douglas Cardoso

doi:10.1016/j.colsurfa.2023.131516

Cited by 5 publications

(1 citation statement)

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“…The complex interplay of these factors makes it difficult to accurately predict the properties of the produced nanofibers [ 9 ]. The most extensively investigated physicochemical properties of nanofibers include their morphology [ 12 ], diameter [ 13 ], inter- and intrafibrilar porosity [ 14 ], crystallinity [ 15 ], mechanical properties (e.g., strength and flexibility) [ 16 , 17 ], swelling of nanofibers [ 17 ], intermolecular interactions [ 18 ], and surface properties [ 19 ]. Moreover, the biological properties of nanofibers, such as biocompatibility, immunomodulatory effects, cell mechanosensing, and effect on cells or tissues, are also considered important aspects of nanofiber characterization [ 17 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

The Incorporated Drug Affects the Properties of Hydrophilic Nanofibers

Dragar,

Roškar,

Kocbek

2024

Nanomaterials

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Hydrophilic nanofibers offer promising potential for the delivery of drugs with diverse characteristics. Yet, the effects of different drugs incorporated into these nanofibers on their properties remain poorly understood. In this study, we systematically explored how model drugs, namely ibuprofen, carvedilol, paracetamol, and metformin (hydrochloride), affect hydrophilic nanofibers composed of polyethylene oxide and poloxamer 188 in a 1:1 weight ratio. Our findings reveal that the drug affects the conductivity and viscosity of the polymer solution for electrospinning, leading to distinct changes in the morphology of electrospun products. Specifically, drugs with low solubility in ethanol, the chosen solvent for polymer solution preparation, led to the formation of continuous nanofibers with uniform diameters. Additionally, the lower solubility of metformin in ethanol resulted in particle appearance on the nanofiber surface. Furthermore, the incorporation of more hydrophilic drugs increased the surface hydrophilicity of nanofiber mats. However, variations in the physicochemical properties of the drugs did not affect the drug loading and drug entrapment efficiency. Our research also shows that drug properties do not notably affect the immediate release of drugs from nanofibers, highlighting the dominant role of the hydrophilic polymers used. This study emphasizes the importance of considering specific drug properties, such as solubility, hydrophilicity, and compatibility with the solvent used for electrospinning, when designing hydrophilic nanofibers for drug delivery. Such considerations are crucial for optimizing the properties of the drug delivery system, which is essential for achieving therapeutic efficacy and safety.

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