Bleeding peptic ulcers and presence of Helicobacter pylori by various tests: a case–control study

Castillo-Rojas, Gonzalo; Ballesteros, M.; León, Sergio; Morales-Espinosa, Rosario; Cravioto, Alejandro; López-Vidal, Yolanda

doi:10.1097/00042737-200210000-00012

Cited by 22 publications

(23 citation statements)

References 30 publications

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“…The greatest increase in risk was found by Santolaria et al [23], who reported a RR of 5.98 (95% CI: 2.9–12.3) in their study of 520 patients in secondary care in Spain. However, a fourth prospective study of 67 patients in Mexico found no association between H. pylori infection and hemorrhage [32]. …”

Section: Resultsmentioning

confidence: 99%

Systematic Review of the Epidemiology of Complicated Peptic Ulcer Disease: Incidence, Recurrence, Risk Factors and Mortality

Lau

Sung²,

Hill³

et al. 2011

Digestion

450

334

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Background/Aims: The incidence of uncomplicated peptic ulcer has decreased in recent years. It is unclear what the impact of this has been on the epidemiology of peptic ulcer complications. This systematic review aimed to determine the incidence, recurrence and mortality of complicated peptic ulcer and the risk factors associated with these events. Methods: Systematic PubMed searches. Results: Overall, 93 studies were identified. Annual incidence estimates of peptic ulcer hemorrhage and perforation were 19.4–57.0 and 3.8–14 per 100,000 individuals, respectively. The average 7-day recurrence of hemorrhage was 13.9% (95% CI: 8.4–19.4), and the average long-term recurrence of perforation was 12.2% (95% CI: 2.5–21.9). Risk factors for peptic ulcer complications and their recurrence included nonsteroidal anti-inflammatory drug and/or acetylsalicylic acid use, Helicobacter pylori infection and ulcer size ≧1 cm. Proton pump inhibitor use reduced the risk of peptic ulcer hemorrhage. Average 30-day mortality was 8.6% (95% CI: 5.8–11.4) after hemorrhage and 23.5% (95% CI: 15.5–31.0) after perforation. Older age, comorbidity, shock and delayed treatment were associated with increased mortality. Conclusions: Complicated peptic ulcer remains a substantial healthcare problem which places patients at a high risk of recurrent complications and death.

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Section: Resultsmentioning

confidence: 99%

Systematic Review of the Epidemiology of Complicated Peptic Ulcer Disease: Incidence, Recurrence, Risk Factors and Mortality

Lau

Sung²,

Hill³

et al. 2011

Digestion

450

334

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“…pylori cagA identification was carried out using the primers cagA1 (93089) (5Ј-ATACACCAACGCCTCCAAG-3Ј) and cagA2 (93261) (5Ј-TTGTTGCCG CTTTTGCTCTC-3Ј) as described by Castillo-Rojas et al (9).…”

Section: Methodsmentioning

confidence: 99%

Longitudinal Study of Microbial Diversity and Seasonality in the Mexico City Metropolitan Area Water Supply System

Mazarí-Hiriart

López-Vidal

Ponce-de-León

et al. 2005

Appl Environ Microbiol

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In the Mexico City metropolitan area (MCMA), 70% of the water for 18 million inhabitants is derived from the Basin of Mexico regional aquifer. To provide an overview of the quality of the groundwater, a longitudinal study was conducted, in which 30 sites were randomly selected from 1,575 registered extraction wells. Samples were taken before and after chlorine disinfection during both the rainy and dry seasons (2000-2001). Microbiological parameters (total coliforms, fecal coliforms, streptococci, and Vibrio spp.), the presence of Helicobacter pylori, and physicochemical parameters, including the amount of trihalomethanes (THMs), were determined. Although microorganisms and inorganic and organic compounds were evident, they did not exceed current permissible limits. Chlorine levels were low, and the bacterial counts were not affected by chlorine disinfection. Eighty-four bacterial species from nine genera normally associated with fecal contamination were identified in water samples. H. pylori was detected in at least 10% of the studied samples. About 40% of the samples surpassed the THM concentration allowed by Mexican and U.S. regulations, with levels of chloroform being high. The quality of the water distributed to the MCMA varied between the rainy and dry seasons, with higher levels of pH, nitrates, chloroform, bromodichloromethane, total organic carbon, and fecal streptococci during the dry season. This study showed that the groundwater distribution system is susceptible to contamination and that there is a need for a strict, year-round disinfection strategy to ensure adequate drinking-water quality. This situation in one of the world's megacities may reflect what is happening in large urban centers in developing countries which rely on a groundwater supply.

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“…In the time period (1998-2012), when eradication therapies were used in addition to PPIs, bleeding did not decrease; indeed its frequency was increased significantly (p<0.05). Despite new improved therapeutic modalities, this unexpected rise in bleeding may be due to other reasons; for example, H. pylori may not be the predominant etiologic factor in patients who experience complications requiring surgery (12,13). During the last decade, PU bleeding did not significantly change (2,5,14), but the incidence increased in patients older than 75 years of age (15).…”

Section: Original Articlementioning

confidence: 99%

Peptic ulcer complications requiring surgery: What has changed in the last 50 years in Turkey

Güzel

Kahramanca²,

Seker³

et al. 2014

Turk J Gastroenterol

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Background/Aims: The incidence and prevalence of peptic ulcer disease has decreased in recent years, but it is not so easy to make the same conclusion when complications of peptic ulcer are taken into consideration. The aim of this study is to determine the time trends in complicated peptic ulcer disease and to state the effects of H2 receptor blockers, proton pump inhibitors (PPI), and H. pylori eradication therapies on these complications. Materials and Methods: This study retrospectively evaluated the patients who were operated on for complications (perforation, bleeding, and obstruction) of peptic ulcer for the last 50 years. Patients were grouped into four groups (G1-G4) according to the dates in which H2 receptor blockers, PPIs, and eradication regimens for H. pylori were introduced The time periods that were studied were: (G1) 1962-1980, (G2) 1981-1990, (G3) 1991-1997, and (G4) 1998-2012. Results: In total, 2953 patients were operated on for complications of peptic ulcer disease, of which 86% of the patients were male. In G1, perforation and obstruction were significantly the most frequent complications (p<0.001), followed by bleeding. In groups G2 and G3, obstruction was still the most frequent complication requiring surgery (p<0.001). In G2 and G3, obstruction was followed by perforation and bleeding, respectively. In G4, perforation was significantly the most frequent complication (p<0.001). Conclusion: From 1962 to 1990 obstruction was the most common complication requiring surgery. In the last decade, perforation became the most common complication. In contrast to reports in the literature, bleeding was the least common complication requiring surgery in Turkey.

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Bleeding peptic ulcers and presence of Helicobacter pylori by various tests: a case–control study

Cited by 22 publications

References 30 publications

Systematic Review of the Epidemiology of Complicated Peptic Ulcer Disease: Incidence, Recurrence, Risk Factors and Mortality

Systematic Review of the Epidemiology of Complicated Peptic Ulcer Disease: Incidence, Recurrence, Risk Factors and Mortality

Longitudinal Study of Microbial Diversity and Seasonality in the Mexico City Metropolitan Area Water Supply System

Peptic ulcer complications requiring surgery: What has changed in the last 50 years in Turkey

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