Bleeding gastric metastatic melanoma

Bargiggia, S.; Parente, Francisco; Ucci, G.; Tricomi, Paolo; Zerbi, Pietro; Vago, Luca

doi:10.1016/j.dld.2008.02.002

Cited by 3 publications

(2 citation statements)

References 2 publications

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“…Symptoms include mainly gastrointestinal bleeding, abdominal pain, anorexia, nausea and vomiting, weight loss, progressive dysplasia, obstruction, and occasionally acute perforation. Melena in a melanoma patient seems to be a primary symptom for gastrointestinal metastasis, even in the absence of other symptoms [10]. In our case our patient never experienced melena.…”

Section: Discussionmentioning

confidence: 45%

Malignant melanoma of the stomach presenting in a woman: a case report

et al. 2011

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IntroductionMalignant melanoma is reported to metastasize to all organs of the human body. Although it is common for it to metastasize to the gastrointestinal tract, a melanoma located primarily in the gastric mucosa is an uncommon tumor. Gastrointestinal metastases are rarely diagnosed before death with radiological and endoscopic techniques.Case presentationIn this case report the clinical course and treatment of a woman with melanoma of the stomach, without any other detectable primary lesion, is presented and discussed. A 55-year-old Turkish woman presented to our clinic with complaints of muscle pain and bone pain in the left side of her chest. During an upper gastrointestinal system endoscopy, dark cherry-colored, light elevated, round-shaped lesions were taken from her gastric fundus and from the first part of her duodenum. Biopsies from these samples were determined to be malignant melanoma by the pathologist.ConclusionMetastatic malignant melanoma cases should be examined through endoscopy for gastrointestinal metastases.

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Section: Discussionmentioning

confidence: 45%

Malignant melanoma of the stomach presenting in a woman: a case report

et al. 2011

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“…Endoscopy is reserved for bleeding MM metastases. The effect can be limited; still, the following treatment options can be used and are available: adrenaline injections, haemoclips, argon plasma coagulation, and haemospray [34][35][36].…”

Section: Treatment 161 Endoscopymentioning

confidence: 99%

Malignant Melanoma of the Gastrointestinal Tract: Symptoms, Diagnosis, and Current Treatment Options

Kohoutová

Worku

Aziz

et al. 2021

Cells

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Malignant melanoma (MM) has become the fifth most frequent cancer in the UK. It is the most common carcinoma to metastasize to the gastrointestinal (GI) tract. MM particularly has an affinity to spread to the small bowel, which is followed by the involvement of the stomach and large intestine. Excellent endoscopic options including video capsule endoscopy and enteroscopy are available for a precise diagnosis of GI involvement by a metastatic MM. The complete surgical resection of GI metastatic MM in carefully selected patients not only provides symptom control, but has also been associated with an increase in overall survival. The approval of BRAF-targeted therapies and immune checkpoint inhibitors has transformed therapeutic approaches for patients with metastatic MM over the past decade. Currently, the overall survival of patients with advanced metastatic MM who have been treated with a combination of immunotherapeutic agents reaches 52% at five years. The role of surgery for patients with the metastatic involvement of the GI tract with MM is evolving in the era of effective systemic treatments.

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Endoscopic diagnosis of gastric metastases from malignant melanoma: systematic review

et al. 2022

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Background/Aims: Metastases of malignant melanoma (MM) are rare and associated with poor prognosis. The objective of this study was to analyze the clinical and endoscopic characteristics of MM gastric metastases by systematically reviewing cases and case series involving patients diagnosed using upper gastrointestinal endoscopy. Methods: The PubMed and LILACS databases were searched. Reports containing individual patient data were included. Outcomes such as clinical data, endoscopic findings, treatments, and survival were analyzed. Results: A total of 88 studies with individual data from 113 patients with gastric metastases of MM were included. The primary sites of MM were the skin (62%), eyes (10%), and mucous membranes (6%). Most patients (56%) had multiple metastases in the stomach, located predominantly in the gastric body (approximately 80%). The overall survival at 2 years was 4%. There was a significant reduction in the survival of patients with multiple gastric metastases compared to that of patients with single metastasis (HR, 0.459; 95% CI, 0.235−0.895; p=0.022). Conclusions: MM gastric metastases have a poor prognosis, especially in patients with multiple implants in the stomach. Additional studies are needed to verify whether ocular and mucosal melanomas are associated with a higher risk of gastric metastases than that of cutaneous melanomas.

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Bleeding gastric metastatic melanoma

Cited by 3 publications

References 2 publications

Malignant melanoma of the stomach presenting in a woman: a case report

Malignant melanoma of the stomach presenting in a woman: a case report

Malignant Melanoma of the Gastrointestinal Tract: Symptoms, Diagnosis, and Current Treatment Options

Endoscopic diagnosis of gastric metastases from malignant melanoma: systematic review

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