Blastomycosis-like pyoderma in a case of chronic myeloid leukaemia

Tk, Dutta; Joseph, James; Baruah, M. C.; Ratnakar, C.

doi:10.1136/pgmj.68.799.363

Cited by 18 publications

(15 citation statements)

References 2 publications

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“…7 Among other things, it has since been deemed a form of pemphigus, a variant of dermatitis herpetiformis and a reaction to infection. 8 It has been associated not only with IBD but also with diffuse T-cell lymphoma, 9 chronic myeloid leukemia, 10 and malnutrition. 11 13 All 3 reviews discuss distinctive clinical, histopathological, and immunofluorescent findings.…”

Section: Discussionmentioning

confidence: 99%

Pemphigus Vegetans Variant of IgA Pemphigus, a Variant of IgA Pemphigus and Other Autoimmune Blistering Disorders

Wolz¹,

Camilleri

McEvoy³

et al. 2013

The American Journal of Dermatopathology

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Pyodermatitis-pyostomatitis vegetans (PPV) constitutes an inflammatory mucocutaneous dermatosis that is associated with inflammatory bowel disease. Clinically, PPV appears as pustules on mucosal surfaces and as vegetating exudative plaques on intertriginous surfaces. It is typically a clinical diagnosis supported by histological findings. Microscopic findings include epidermal hyperplasia, focal acantholysis, and a dense mixed inflammatory infiltrate with intraepithelial and subepithelial eosinophilic microabscesses. In the recent literature, immunofluorescence has been thought to be negative in PPV or, if positive, an aberrant finding. Herein, we report 2 cases of PPV associated with inflammatory bowel disease, which display intercellular IgA deposits. Although these cases may represent isolated epiphenomena, it is possible that the paucity of PPV cases with immunofluorescent studies hitherto has led to an oversight of an interesting association between intercellular IgA and PPV.

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Section: Discussionmentioning

confidence: 99%

Pemphigus Vegetans Variant of IgA Pemphigus, a Variant of IgA Pemphigus and Other Autoimmune Blistering Disorders

Wolz¹,

Camilleri

McEvoy³

et al. 2013

The American Journal of Dermatopathology

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“…2 Bacteria such as Staphylococcus, 3,4 Streptococcus, 5,6 and Pseudomonas aeruginosa 7,8 have been detected in cultures of BLP samples, and cases of BLP usually respond to antibiotic therapy.…”

Section: Discussionmentioning

confidence: 99%

A Case of Blastomycosis-Like Pyoderma Caused by Mixed Infection of Staphylococcus epidermidis and Trichophyton rubrum

O‐Uchi

Tamura²,

Nishimoto³

et al. 2011

The American Journal of Dermatopathology

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Blastomycosis-like pyoderma (BLP) is a type of chronic pyoderma characterized histologically by specific epidermal changes namely: pseudoepitheliomatous hyperplasia and intraepithelial abscesses. These epidermal changes are also seen in blastomycosis (referred to as deep dermatophytosis in North America). Here, we describe the case of a 53-year-old male with prurigo nodularis, diabetes, and chronic lymphocytic leukemia who presented with multiple yellowish-red colored papules that coalesced to form a vegetating plaque. In addition to the typical features of BLP, spores with budding were seen histopathologically in a biopsy specimen. Cultures of a skin specimen grew Staphylococcus epidermidis and Trichophyton rubrum. Antibiotic therapy was effective but failed to eliminate the lesion until antifungal therapy using terbinafine was administered concurrently. Past reports suggest that BLP is mainly caused by bacterial infection, but our case suggests that fungal infection can also be involved as the causative organism in BLP.

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“…2,6,9 Pyoderma vegetans has been associated with ulcerative colitis, 5 diffuse T-cell lymphoma, 6 alcoholism with malnutrition, 1 HIV infection, 7 and chronic myeloid leukemia. 10 Su et al 2 reported seven patients with clinically characteristic pyoderma vegetans. It was proposed that these patients had various immunocompromising conditions that predisposed them to bacterial infections, including chronic granulocytic leukemia, pulmonary granuloma, seminoma treated with x-ray irradiation, and arthritis treated with azathioprine and prednisone.…”

Section: Discussionmentioning

confidence: 98%

Pyoderma Vegetans

Papadopoulos

Schwartz

Kapila

et al. 2001

Journal of Cutaneous Medicine and Surgery: Incorporating Medica

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Pyoderma vegetans is diagnosed on clinical and histological criteria. Differentiation must be made from disorders such as pyoderma gangrenosum, Sweet's syndrome, and deep fungal infections. We illustrate a case of pyoderma vegetans and review the literature on this rare disorder. Clinical and histological criteria for diagnosis are presented, as well as differentiation from some mimicking disorders.

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Blastomycosis-like pyoderma in a case of chronic myeloid leukaemia

Abstract: Summary:Blastomycosis-like pyoderma, a rare skin lesion which may clinically resemble true blastomycosis, is seen in immuno-compromised individuals. We report one such case in chronic myeloid leukaemia.

Cited by 18 publications

References 2 publications

Pemphigus Vegetans Variant of IgA Pemphigus, a Variant of IgA Pemphigus and Other Autoimmune Blistering Disorders

Pemphigus Vegetans Variant of IgA Pemphigus, a Variant of IgA Pemphigus and Other Autoimmune Blistering Disorders

A Case of Blastomycosis-Like Pyoderma Caused by Mixed Infection of Staphylococcus epidermidis and Trichophyton rubrum

Pyoderma Vegetans

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