Pyoderma Vegetans

Papadopoulos, Anthony J.; Schwartz, Robert A.; Kapila, Rajendra; Samady, Joseph A.; Ruszczak, Z; Rao, Babar; Lambert, W. Clark

doi:10.1007/s102270000023

Cited by 6 publications

(4 citation statements)

References 22 publications

(59 reference statements)

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“…The histopathologic hallmarks of blastomycosis-like pyoderma are pseudo-epitheliomatous hyperplasia, intraepidermal, subepidermal microabscesses and dense dermal inflammatory infiltration11,12. There is usually no granuloma formation.…”

Section: Discussionmentioning

confidence: 99%

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Blastomycosis-like Pyoderma with Good Response to Acitretin

et al. 2011

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Blastomycosis-like pyoderma is a rare, vegetating skin lesion that is an unusual exaggerated tissue reaction possibly to prolonged primary or secondary bacterial infection. We report a case of blastomycosis-like pyoderma in a man with Down syndrome, diabetes mellitus and hypothyroidism who responsed poorly to conventional therapies, including antibiotics and correction of predisposing factors for a long time, but experienced dramatic improvement after 3 months of acitretin treatment.

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Section: Discussionmentioning

confidence: 99%

“…The differential diagnoses of the disease include North American blastomycosis, chromoblastomycosis, pyoderma gangrenosum, pemphigus vegetans, tuberculosis verrucosa cutis, halogenoderma, and squamous cell carcinoma3,12,14.…”

Section: Discussionmentioning

confidence: 99%

Blastomycosis-like Pyoderma with Good Response to Acitretin

et al. 2011

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“…The main pitfall is the risk of clinically misdiagnosing this rare condition. Since pemphigus vegetans may show clinical and histopathological findings similar to PV, the two are difficult to distinguish from each other [4, 6]. The differential diagnosis of PV should include pemphigus vegetans and deep fungal infections.…”

Section: Discussionmentioning

confidence: 99%

“…PV often affects middle-aged men, is frequently associated with ulcerative colitis (UC) and is often difficult to treat [2]. Other diseases that might be linked to this condition include cutaneous T-cell lymphoma, primary immunodeficiencies, chronic myeloid leukemia, alcoholism, HIV infection and nutritional deficit [2, 3, 4]. Predisposing factors include microbial infections, halogen ingestion, foreign materials and tattoos in patients with a compromised immune system [3].…”

Section: Introductionmentioning

confidence: 99%

Pyoderma Vegetans Associated with Ulcerative Colitis: A Case with Good Response to Steroids

Canpolat¹,

Cemil²,

Yılmazer

et al. 2011

Case Rep Dermatol

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Pyoderma vegetans (PV) is a very rare disorder characterized by erythematous, vesiculopustular, exudative, vegetating plaques usually localized in the inguinal and axillary folds. The etiology of PV is not known, but it is often associated with bacterial infections in immunocompromised patients. Major histopathological features in PV are pseudoepitheliomatous hyperplasia and intraepidermal and subepidermal neutrophilic or eosinophilic microabscesses. It is well known that these lesions are frequently associated with inflammatory bowel diseases, such as ulcerative colitis (UC) and Crohn’s disease. No standardized treatment plan is available for PV, although antibiotic treatment has often been used, with variable results. The standard first-line therapy is still systemic steroids. Herein, we report a case of PV associated with UC with unusual localization that showed a good response to systemic corticosteroid, antibiotic and sulfasalazine therapy.

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