Blastomycosis in solid organ transplant recipients

Gauthier, Gregory M.; Safdar, Nasia; Klein, Bruce S.; Andes, David R.

doi:10.1111/j.1399-3062.2007.00227.x

Cited by 117 publications

(152 citation statements)

References 48 publications

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“…A urinary antigen enzyme immunoassay for B. dermatitidis is currently available (112), but significant crossreactivity with histoplasmosis has been noted. Tissue biopsy with histopathological examination and cytological studies (131,281). Pneumonia was the most common clinical presentation and was frequently complicated with acute respiratory distress syndrome.…”

Section: Other Regional Fungal Infectionsmentioning

confidence: 99%

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

et al. 2008

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SUMMARY In recent years, the increasing number of donors from different regions of the world is providing a new challenge for the management and selection of suitable donors. This is a worldwide problem in most countries with transplantation programs, especially due to the increase in immigration and international travel. This paper elaborates recommendations regarding the selection criteria for donors from foreign countries who could potentially transmit tropical or geographically restricted infections to solid-organ transplant recipients. For this purpose, an extensive review of the medical literature focusing on viral, fungal, and parasitic infections that could be transmitted during transplantation from donors who have lived or traveled in countries where these infections are endemic has been performed, with special emphasis on tropical and imported infections. The review also includes cases described in the literature as well as risks of transmission during transplantation, microbiological tests available, and recommendations for each infection. A table listing different infectious agents with their geographic distributions and specific recommendations is included.

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Section: Other Regional Fungal Infectionsmentioning

confidence: 99%

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

et al. 2008

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“…Voriconazole has also been used in settings where itraconazole is not tolerated or adequate serum levels cannot be obtained [47]. For example, patients requiring medications to suppress gastric acidity, including proton pump inhibitors or histamine-2 blockers, should not be prescribed itraconazole capsules.…”

Section: Blastomycosismentioning

confidence: 98%

The Role of Second-Generation Antifungal Triazoles for Treatment of the Endemic Mycoses

Freifeld

Bariola

Andes

2010

Curr Infect Dis Rep

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Endemic fungi are geographically restricted to certain areas of the United States where they are typically found in soil. They often cause asymptomatic or self-limited flu-like infections in humans. Occasionally, they cause serious human disease including acute or chronic pneumonias, or bone, skin, or central nervous system disease. Amphotericin B and first-generation triazoles are standard therapy for serious endemic fungal infections. Adverse effects, drug intolerance, and rare refractory infections may limit their use; therefore, experience is increasing using newer triazoles (voriconazole and posaconazole) to potentially circumvent these problems. This article reviews the basic scientific information and clinical experience using triazoles for treating endemic fungal infections.

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“…Cutaneous Alternaria infections manifest as solitary or grouped papules, plaques, or nodules that may have granulomas, and mainly involve the lower extremities; numerous cases in transplant recipients have been reported in recent years [ 39 ]. A review of 11 cases of blastomycosis in SOT recipients at a transplant center in Wisconsin found skin involvement in 3, with concomitant lung infection in 1 [ 40 ]. Deeper skin infections (eg, necrotizing fasciitis) in transplant recipients can be caused by fungal pathogens such as mucormycosis [ 3 ], Cryptococcus [ 4 ], and Candida albicans [ 5 ].…”

Section: Fungal Skin and Soft Tissue Infectionsmentioning

confidence: 99%

Skin and soft tissue infections in the transplant population

Kotton

2008

Curr Infect Dis Rep

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Solid organ and hematopoietic stem cell transplant recipients are more likely to develop skin and soft tissue infections, which may be caused by common or atypical pathogens. Skin and soft tissue anatomic abnormalities may act as portals of entry for infection, and may result from surgery, venous access, immunosuppressive medications, and other etiologies. Systemic infection may sometimes be recognized by investigation of skin manifestations. Many noninfectious processes of the skin and soft tissues can mimic infection, complicating the diagnosis. Prompt dermatologic consultation and skin biopsy are essential in this vulnerable population. Treatment of infection in transplant recipients may necessitate reduction of immunosuppression, in addition to other adjunctive therapies. Interesting and important new findings about skin and soft tissue infections in transplant recipients are the focus of this review.

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Blastomycosis in solid organ transplant recipients

Abstract: Blastomycosis is an uncommon infection following solid organ transplantation that is frequently complicated by ARDS, dissemination, and opportunistic co-infection. After cure, post-transplant blastomycosis may not require lifelong antifungal suppression.

Cited by 117 publications

References 48 publications

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

The Role of Second-Generation Antifungal Triazoles for Treatment of the Endemic Mycoses

Skin and soft tissue infections in the transplant population

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