Bladder wall thickness in normal adults and men with mild lower urinary tract symptoms and benign prostatic enlargement

Hakenberg, Oliver W.; Linné, C.; Manseck, Andreas; Wirth, Manfred P.

doi:10.1002/1520-6777(2000)19:5<585::aid-nau5>3.0.co;2-u

Cited by 143 publications

(92 citation statements)

References 20 publications

(17 reference statements)

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“…Another limitation to the study was that our control group was not age-matched. In the literature, however, the measurement error of ultrasonography was found to be even more significant than BWT differences in different age groups (5). Thus, we feel that the control group not being age-matched is not a significant limitation.…”

Section: Discussionmentioning

confidence: 79%

“…who was blinded to the IPSS results and LUTS severity of the men in the study groups, ultrasonography itself is a subjective assessment modality and is operator dependent. Currently, DWT measurement techniques have started to become standardized through numerous studies (4,5,7,9,10,19). It was previously demonstrated that DWT depends only on gender, bladder filling, and LUTS severity (7,18), and DWT was not affected by patient age (19).…”

Section: Discussionmentioning

confidence: 99%

“…From a clinical perspective, thickening of the bladder wall should be considered as a sign of significant subvesical obstruction (5). The best way to visualize this detrusor muscle hypertrophy in a noninvasive manner is to measure the detrusor wall thickness (DWT) by suprapubic ultrasonography.…”

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confidence: 99%

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Diagnostic values of detrusor wall thickness, postvoid residual urine and prostate volume to evaluate lower urinary tract symptoms in men

Tokgöz

Tokgöz²,

Ünal³

et al. 2011

Diagn Interv Radiol

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Lower urinary tract symptoms (LUTS) are common, affecting approximately 40% of older men (1). LUTS is a recent term for what used to be known as prostatism (2). However, obstructive disorders of the lower urinary tract may also be caused by other diseases, such as bladder neck contractures, urethral valves, or external sphincter dyssynergia. However, for the majority of cases in the male population, the etiology is benign prostatic hyperplasia (BPH).Various animal and human studies have revealed that a significant enlargement of the bladder wall is attributable to smooth muscle cell hypertrophy, fibrocyte hyperplasia, and collagen deposition in the detrusor (3, 4). From a clinical perspective, thickening of the bladder wall should be considered as a sign of significant subvesical obstruction (5). The best way to visualize this detrusor muscle hypertrophy in a noninvasive manner is to measure the detrusor wall thickness (DWT) by suprapubic ultrasonography. In 2006, Belal and Abrams (6) evaluated noninvasive methods used to diagnose bladder outlet obstruction (BOO) in a meta-analysis and observed that ultrasound measurements of the DWT and bladder weight were the only predictors of subvesical obstruction in LUTS patients.It is widely accepted that DWT decreases continuously while the bladder fills to 50% of its capacity and then remains constant until 100%. Therefore, the detrusor wall measurements are performed on patients when the bladder is filled to maximum capacity only (7). However, no study has been published that evaluates the diagnostic accuracy of DWT when the bladder is empty. In our study, we investigated the association between the LUTS severity and DWT. In addition, the parameter "DWT when the bladder was empty" was also evaluated as a noninvasive diagnostic tool to predict LUTS in men.An ideal assessment tool to detect LUTS must be noninvasive, quick, inexpensive, and reproducible with high diagnostic accuracy. Ultrasonography has all of these criteria with additional advantages (no contrast material and no ionizing radiation). In uro-radiology practice, conventional ultrasound-derived noninvasive tests for the evaluation of LUTS severity can achieve measurements of DWT, postvoid residual urine volume (PVR), and prostate and bladder volumes. Hence, our primary aim in this prospective, controlled clinical study was to analyze the diagnostic accuracy of these ultrasound-derived noninvasive tools (i.e., DWT when the bladder is full and empty, PVR, and bladder and prostate volumes) in healthy, mildly symptomatic, and moderately-toseverely symptomatic men, and compare the outcomes in each group. In addition, their correlation according to International Prostate Symptom Score (IPSS) and age groups as well as differences in DWT values were also investigated. Our hypothesis was that these tests would accurately discriminate symptomatic cases from healthy subjects and would ABDOMINAL IMAGING MATERIALS AND METHODSDuring an 18-month period, a total of 243 males were included in the study. Three groups were a...

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

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Diagnostic values of detrusor wall thickness, postvoid residual urine and prostate volume to evaluate lower urinary tract symptoms in men

Tokgöz

Tokgöz²,

Ünal³

et al. 2011

Diagn Interv Radiol

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“…The internal contours of these organs are automatically constructed from the delineated outer wall surface. The inner wall was constructed with a 3 mm distance in all direction from the outer wall for both rectum and bladder [8]. Then, the dose-volume-histograms (DVHs) were generated and analysed.…”

Section: Dosimetric and Radiobiological Variablesmentioning

confidence: 99%

Radiation-induced complications in prostate cancer patients treated with radiotherapy

Azuddin

Rahman²,

Siah

et al. 2014

AIP Conference Proceedings

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Abstract. The purpose of the study is to determine the relationship between radiation-induced complications with dosimetric and radiobiological parameters for prostate cancer patients that underwent the conformal radiotherapy treatment. 17 prostate cancer patients that have been treated with conformal radiotherapy were retrospectively analysed. The dosimetric data was retrieved in the form of dose-volume histogram (DVH) from Radiotherapy Treatment Planning System. The DVH was utilised to derived Normal Tissue Complication Probability (NTCP) in radiobiological data. Follow-up data from medical records were used to grade the occurrence of acute gastrointestinal (GI) and genitourinary (GU) complications using Radiation Therapy Oncology Group (RTOG) scoring system. The chi-square test was used to determine the relationship between radiation-induced complication with dosimetric and radiobiological parameters. 8 (47%) and 7 (41%) patients were having acute GI and GU complications respectively. The acute GI complication can be associated with V60 rectum , rectal mean dose and NTCP rectum with p-value of 0.016, 0.038 and 0.049 respectively. There are no significant relationships of acute GU complication with dosimetric and radiobiological variables. Further study can be done by increase the sample size and follow up duration for deeper understanding of the factors that effecting the GU and GI complication in prostate cancer radiotherapy.

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“…When the bladder wall muscle becomes thicker as a result of prostatic obstruction and compensation, the bladder wall thickness (BWT) becomes a non-invasive parameter to assess BOO (25,26). BWT may result from smooth muscle hypertrophy secondary to BOO, as well as collagen and fibrous tissue, both consequences of obstruction and aging (27,28).…”

Section: Bladder Wall Thickness and Bladder Weightmentioning

confidence: 99%

Noninvasive Methods to Evaluate Bladder Obstruction in Men

Chughtai

Lee

et al. 2013

Int. braz j urol.

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Bladder wall thickness in normal adults and men with mild lower urinary tract symptoms and benign prostatic enlargement

Cited by 143 publications

References 20 publications

Diagnostic values of detrusor wall thickness, postvoid residual urine and prostate volume to evaluate lower urinary tract symptoms in men

Diagnostic values of detrusor wall thickness, postvoid residual urine and prostate volume to evaluate lower urinary tract symptoms in men

Radiation-induced complications in prostate cancer patients treated with radiotherapy

Noninvasive Methods to Evaluate Bladder Obstruction in Men

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