“…As the cells build their microenvironment through matrix deposition, it could be expected that tissues, free of exogenous materials, will show matrix–cell and cell–cell interactions that more accurately reproduce the native tissue. Through the years, this technique was extended to research on several tissues, such as cornea (Proulx et al ., ), hypodermis (Vermette et al ., ), bladder (Magnan et al ., ; Bouhout et al ., ; Bouhout et al ., ), urethra (Magnan et al ., ; Cattan et al ., ) and skin with physiological or pathological features [psoriasis (Jean et al ., ), scleroderma (Corriveau et al ., ), hypertrophic scarring (Simon et al ., ) or melanoma (Auger et al ., )]. Moreover, from a clinical point of view, this technique is also used on a small scale for the treatment of burned patients (Auger et al ., ).…”