Bladder squamous cell cancer accompanied by Trousseau's syndrome: a case report

Abstract

Key Clinical MessageThe association between thrombosis and cancer has been recognized since Trousseau's report in 1865. We present a case of bladder squamous cell carcinoma associated with multiple cerebral infarctions. This patient was diagnosed as having Trousseau's syndrome and received radiotherapy for bladder cancer treatment, along with anticoagulation therapy.

Trousseau's Syndrome Presenting as Multiple Cerebral Infarctions Caused by Mucin-producing Bladder Micropapillary Urothelial Cancer

“…If the subjects had been limited to those with Trousseau's syndrome, we speculate that the frequency would have been less than that in the present report. To our knowledge, only five cases (including the present case) of Trousseau's syndrome with CI in patients with bladder cancer have been reported thus far (Table) (12)(13)(14)(15), and some may not have had cancer-associated hypercoagulopathy, since the D-dimer level in those cases was not elevated.…”

Trousseau's syndrome manifesting as multiple cerebral infarctions caused by bladder cancer

“…Our present case included characteristics, such as the presence of hypertension and DM, receiving bed rest for a night following the surgery, asymptomatic splenic thrombosis, and advanced bladder cancer. To our best knowledge, this case was the fourth reported case of CI as Trousseau's syndrome caused by bladder cancer, but it was the second reported case of severe CI caused by bladder cancer that was sufficient to directly lead to death 3 , 4 . The characteristics of CI as Trousseau's syndrome observed using MRI include lesions that are multiple, disseminated, bilateral, and of various sizes, located across the governing region of different cerebral arteries, and often with cerebellar infarction 2 .…”

“…In a narrow definition, it would include only severe thromboses, such as symptomatic CI 1 , 2 . Adenocarcinoma and mucinous carcinoma in the lung, pancreas, breast, ovary, stomach, or prostate are known as the causative cancer of this syndrome; however, the syndrome being caused by bladder cancer has rarely been reported in the literature 3 , 4 . Here, we report the case of a male patient in whom Trousseau's syndrome manifested as crucial multiple CIs caused by bladder cancer following trans -urethral resection (TUR) in the hospital.…”