Bladder Reconstitution With Bone Marrow Derived Stem Cells Seeded on Small Intestinal Submucosa Improves Morphological and Molecular Composition

Chung, Steve Y.; Krivorov, Nikola; Rausei, Veronica; Thomas, Lisa S.; Frantzen, Malka; Landsittel, Douglas; Kang, Young Mi; Chon, Chris H.; Ng, Christopher; Fuchs, Gerhard

doi:10.1097/01.ju.0000161592.00434.c1

Cited by 116 publications

(59 citation statements)

References 20 publications

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“…A similar architecture was also apparent in the control group that was not seeded with MSCs, although a longer duration was required to distinguish the three layers. 37 Although migration of cells from native tissue more than likely contributed to the findings, the transplanted stem cells imparted an observable advantage. However, the responsible mechanism remains to be elucidated.…”

Section: Seeded Cell Type: the Application Of Stem Cellsmentioning

confidence: 95%

Tissue engineering in urology

Matoka

Cheng

2013

CUAJ

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Tissue engineering encompasses a multidisciplinary approach geared toward the development of biological substitutes designed to restore and maintain normal function in diseased or injured tissues. This article reviews the basic technology that is used to generate implantable tissue-engineered grafts in vitro that will exhibit characteristics in vivo consistent with the physiology and function of the equivalent healthy tissue. We also examine the current trends in tissue engineering designed to tailor scaffold construction, promote angiogenesis and identify an optimal seeded cell source. Finally, we describe several currently applied therapeutic modalities that use a tissue-engineered construct. While notable progress has clearly been demonstrated in this emerging field, these efforts have not yet translated into widespread clinical applicability. With continued development and innovation, there is optimism that the tremendous potential of this field will be realized.Can Urol Assoc J 2009;3(5):403-8 Résumé L'ingénierie tissulaire englobe une approche multidisciplinaire axée sur le développement de substituts biologiques en vue de rétablir et de maintenir la fonction normale de tissus lésés. L'article qui suit passe en revue la technologie fondamentale utilisée pour générer des greffons implantables produits par ingénierie in vitro et possédant des caractéristiques in vivo correspondant aux tissus sains équivalents sur les plans physiologique et fonctionnel. Nous examinons également les tendances actuelles en ingénierie tissulaire visant à adapter des échafaudages tissulaires, à promouvoir l'angiogenèse et à dégager une source optimale de cellules implantables. Enfin, nous décrivons plusieurs modalités thérapeu-tiques actuellement mises en application utilisant un échafaudage créé par ingénierie tissulaire. En dépit de progrès remarquables dans ce domaine en effervescence, les efforts déployés ne se sont pas encore traduits par une applicabilité clinique étendue. Des développements et des percées continus permettent d'être optimiste face au potentiel prodigieux de ce domaine.

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Section: Seeded Cell Type: the Application Of Stem Cellsmentioning

confidence: 95%

Tissue engineering in urology

Matoka

Cheng

2013

CUAJ

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“…MSCs were shown to migrate to the bladder grafts and differentiate into smooth muscle cells (Kanematsu et al, 2005). These cells achieved fast repopulation of the grafts, which exhibited appropriate neural function and less fibrosis (Chung et al, 2005 (Zhang et al, 2005), and thus the use of MSCs may help to engineer a bladder when no bladder-derived cells are available. Clinical application of bladder tissue engineering has made important steps; however, more needs to be done in the future to achieve the target of whole-organ regeneration and transplantation in urology.…”

Section: Urinary Tissues -Bladdermentioning

confidence: 99%

Updates on stem cells and their applications in regenerative medicine

Bajada

Mazakova

Richardson

et al. 2008

J Tissue Eng Regen Med

305

188

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“…It is for this reason that bone marrow-derived MSCs are an attractive candidate for bladder tissue regeneration (91). Chung et al (92) reported positive results in healthy rat bladders following the introduction of porcine small intestinal submucosa seeded with MSCs from rat bone marrow. These rats exhibited normal urinary bladder architecture, and histological analysis demonstrated well-differentiated urothelial and smooth muscle cells compared with control experiments using unseeded intestinal submucosa (92).…”

Section: Stem Cells In Bladder Regenerationmentioning

confidence: 99%

Bladder reconstruction: The past, present and future

2015

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Abstract. Ileal conduit urinary diversion is the gold standard treatment for urinary tract reconstruction following cystectomy. This procedure uses gastrointestinal segments for bladder augmentation, a technique that is often associated with significant complications. The substantial progression in the fields of tissue engineering and regenerative medicine over the previous two decades has resulted in the development of techniques that may lead to the construction of functional de novo urinary bladder substitutes. The present review identifies and discusses the complications associated with current treatment options post-cystectomy. The current techniques, achievements and perspectives of the use of biomaterials and stem cells in the field of urinary bladder reconstruction are also reviewed.

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Bladder Reconstitution With Bone Marrow Derived Stem Cells Seeded on Small Intestinal Submucosa Improves Morphological and Molecular Composition

Cited by 116 publications

References 20 publications

Tissue engineering in urology

Tissue engineering in urology

Updates on stem cells and their applications in regenerative medicine

Bladder reconstruction: The past, present and future

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