Bladder reconstruction: The past, present and future

El‐Taji, Omar; Khattak, Altaf Q.; Hussain, Syed A.

doi:10.3892/ol.2015.3161

Cited by 40 publications

(20 citation statements)

References 100 publications

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“…Several review articles have been written regarding bladder tissue engineering or bladder reconstruction [20][21][22] . However, a summary of the fi ndings of the basic material properties of the bladder (both human and animal models) are not currently available in the literature.…”

Section: Mechanical Testing Of the Bladdermentioning

confidence: 99%

Understanding the mechanics of the bladder through experiments and theoretical models: Where we started and where we are heading

Roccabianca

Bush

2016

Technology

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Bladder control problems affect both men and women and range from an overactive bladder, to urinary incontinence, to bladder obstruction and cancer. These disorders affect more than 200 million people worldwide. Loss of bladder function significantly affects the quality of life, both physically and psychologically, and also has a large impact on the healthcare system, i.e., the incurring costs related to diagnosis, treatment and medical/nursing care. Improvements in diagnostic capabilities and disease management are essential to improve patient care and quality of life and reduce the economic burden associated with bladder disorders. This paper summarizes some of the key contributions to understanding the mechanics of the bladder ranging from work conducted in the 1970s through the present time with a focus on material testing and theoretical modeling. Advancements have been made in these areas and a significant contribution to these changes was related to technological improvements.

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Section: Mechanical Testing Of the Bladdermentioning

confidence: 99%

Understanding the mechanics of the bladder through experiments and theoretical models: Where we started and where we are heading

Roccabianca

Bush

2016

Technology

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“…Currently, when conservative methods fail, urinary tract is reconstructed using fragments of the gastrointestinal tract [3]. Such surgery always leads to various complications [4]. However, despite the high invasiveness of such intervention, they remain the golden standard in these conditions [5].…”

Section: Introductionmentioning

confidence: 99%

Experimental urinary bladder reconstruction using allogeneic tissue engineering products

Orlova¹,

Muraviov²,

Vinogradova³

et al. 2019

CTT

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“…Despite continent reconstruction of the urinary tract using cutaneous reservoirs or orthotopic diversions being a stepup from ileal conduit urinary diversion, a limited number of patients in practice will have continent urinary reconstruction [ 17 ]. Moreover, whilst the use of tissue engineering in the field of bladder reconstruction post-cystectomy shows great potential, its clinical application in mainstream urological practice seems still quite a way off [ 18 ]. The use of bladder-sparing approaches with regards to MIBC has been extensively investigated over the past two decades.…”

Section: Introductionmentioning

confidence: 99%

Bladder Sparing Approaches for Muscle-Invasive Bladder Cancers

El‐Taji

Alam

Hussain

2016

Curr. Treat. Options in Oncol.

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Opinion statementOrgan preservation has been increasingly utilised in the management of muscle-invasive bladder cancer. Multiple bladder preservation options exist, although the approach of maximal TURBT performed along with chemoradiation is the most favoured. Phase III trials have shown superiority of chemoradiotherapy compared to radiotherapy alone. Concurrent chemoradiotherapy gives local control outcomes comparable to those of radical surgery, but seemingly more superior when considering quality of life. Bladder-preserving techniques represent an alternative for patients who are unfit for cystectomy or decline major surgical intervention; however, these patients will need lifelong rigorous surveillance. It is important to emphasise to the patients opting for organ preservation the need for lifelong bladder surveillance as risk of recurrence remains even years after radical chemoradiotherapy treatment. No randomised control trials have yet directly compared radical cystectomy with bladder-preserving chemoradiation, leaving the age-old question of superiority of one modality over another unanswered. Radical cystectomy and chemoradiation, however, must be seen as complimentary treatments rather than competing treatments. Meticulous patient selection is vital in treatment modality selection with the success of recent trials within the field of bladder preservation only being possible through this application of meticulous selection criteria compared to previous decades. A multidisciplinary approach with radiation oncologists, medical oncologists, and urologists is needed to closely monitor patients who undergo bladder preservation in order to optimise outcomes.

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Bladder reconstruction: The past, present and future

Cited by 40 publications

References 100 publications

Understanding the mechanics of the bladder through experiments and theoretical models: Where we started and where we are heading

Understanding the mechanics of the bladder through experiments and theoretical models: Where we started and where we are heading

Experimental urinary bladder reconstruction using allogeneic tissue engineering products

Bladder Sparing Approaches for Muscle-Invasive Bladder Cancers

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