Bladder outlet obstruction causes up-regulation of nicotinic acetylcholine receptors in bladder-projecting pelvic ganglion neurons

Chung, Hyun Chul; Lee, Choong Ku; Park, Kwang Hwa; Jeong, Seong Woo

doi:10.1016/j.brainres.2015.01.026

Cited by 5 publications

(4 citation statements)

References 61 publications

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“…These features are likely driven by neuronal dysfunction, as nicotinic receptors are expressed by autonomic ganglion neurons and required for transmitting the excitatory message from spinal neurons to ganglion cells, and hence to the organs. Specifically, Chrna3 and Chrnb4 are highly expressed in pelvic ganglia (Park et al, 2006 ; Girard et al, 2013 ) and are upregulated in parasympathetic pelvic ganglion neurons in a surgical obstruction model of the urethra (Chung et al, 2015 ). While not excluding other mechanisms, these reports are consistent with the bladder dysfunction being driven by an inability to void, resulting in distension and hypertrophy of the bladder.…”

Section: Genetic Models Of Bladder Dysfunctionmentioning

confidence: 99%

Developing a functional urinary bladder: a neuronal context

Keast

Smith-Anttila

Osborne

2015

Front. Cell Dev. Biol.

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The development of organs occurs in parallel with the formation of their nerve supply. The innervation of pelvic organs (lower urinary tract, hindgut, and sexual organs) is complex and we know remarkably little about the mechanisms that form these neural pathways. The goal of this short review is to use the urinary bladder as an example to stimulate interest in this question. The bladder requires a healthy mature nervous system to store urine and release it at behaviorally appropriate times. Understanding the mechanisms underlying the construction of these neural circuits is not only relevant to defining the basis of developmental problems but may also suggest strategies to restore connectivity and function following injury or disease in adults. The bladder nerve supply comprises multiple classes of sensory, and parasympathetic or sympathetic autonomic effector (motor) neurons. First, we define the developmental endpoint by describing this circuitry in adult rodents. Next we discuss the innervation of the developing bladder, identifying challenges posed by this area of research. Last we provide examples of genetically modified mice with bladder dysfunction and suggest potential neural contributors to this state.

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Section: Genetic Models Of Bladder Dysfunctionmentioning

confidence: 99%

Developing a functional urinary bladder: a neuronal context

Keast

Smith-Anttila

Osborne

2015

Front. Cell Dev. Biol.

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“…Future developments may involve further studies on NOD-, LRR-and pyrin domain-containing protein 3 (NLRP3) inflammasome, a sensor of cellular damage in the urothelium (27), piezo1, a mechanically activated ion channel present in the detrusor muscle and suburothelial layer implicated in sensation of bladder stretch (28), nicotinic acetylcholine receptors in parasympathetic bladder pelvic ganglion neurons, which expression has been shown to be increased due to its upregulation in BOO (29). The study is not without limitations.…”

Section: Novel Biomarkersmentioning

confidence: 99%

Systematic review of urinary biomarkers of female bladder outlet obstruction (fBOO)

Silva

Dinis²,

Monteiro³

2022

Arch Ital Urol Androl

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Objective: Diagnosis of bladder outlet obstruction (BOO) in females is often challenging, not only because of the overlap in storage and voiding symptoms in women with various etiologies of lower urinary tract (LUT) dysfunction but also due to the lack of standardized urodynamic criteria to define the condition. There is an unmet need of biologic markers to evaluate BOO in females as an adjunct to other clinical criteria. We sought to elucidate the role of urinary biomarkers in female BOO. Material and methods: We performed a systematic review of studies involving urinary biomarkers in female BOO. The search was performed in PubMed. A total of 58 papers were retrieved and 2 were included for final analysis.Results: Currently, there are no validated biologic markers for female BOO available. Having a biomarker that can be obtained through a urine sample will be an invaluable tool to evaluate and counsel patients with LUT symptoms and possible BOO. The use of NGF as an indicator of BOO in female patients seems to be promising: NGF levels are elevated in women with BOO when compared with normal controls. Conclusions: We found that NGF levels may be applied as a useful biomarker in the diagnosis and evaluation of female patients with BOO symptoms. It will not completely replace other clinical diagnostic tools such as formal urodynamic testing but play a role as a supplement to it. Nevertheless, further studies should be conducted to establish NGF levels as a female BOO biomarker and a routine testing modality.

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“…In an animal model, BOO was also found to induce upregulation of nicotinic acetylcholine receptors in parasympathetic bladder pelvic ganglion neurons (56). This suggests a neural effect of BOO, contributing to the development of detrusor overactivity.…”

Section: Biomarkersmentioning

confidence: 99%

New Frontiers in Molecular and Imaging Research on Evaluation and Diagnosis of Bladder Outlet Obstruction in Women

Martínez

Khavari

2017

Curr Bladder Dysfunct Rep

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Purpose Diagnosis of bladder outlet obstruction (BOO) often presents a challenge in female patients. Traditional diagnostic elements such as symptom history and urodynamic data are rarely clear cut in women. Therefore, we sought to review the current literature on diagnosis of female BOO, focusing on new frontiers in the realm of molecular markers and imaging modalities. Recent Findings In addition to fluoroscopy in the setting of videourodynamics, ultrasound and MRI can augment the diagnosis and aid in therapeutic planning in certain etiologies of female BOO. Furthermore, multiple potential biomarkers (i.e. nerve growth factor, prostaglandins, ATP) that have been studied in correlation to BOO in animal models as well as human subjects hold promise for diagnostic applications. Summary These novel techniques may augment standard clinical and urodynamic evaluation of BOO in females. Future directions include further studies of each of these biomarkers in female patients with BOO compared to normal controls to test their feasibility as potential screening tools.

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Bladder outlet obstruction causes up-regulation of nicotinic acetylcholine receptors in bladder-projecting pelvic ganglion neurons

Cited by 5 publications

References 61 publications

Developing a functional urinary bladder: a neuronal context

Developing a functional urinary bladder: a neuronal context

Systematic review of urinary biomarkers of female bladder outlet obstruction (fBOO)

New Frontiers in Molecular and Imaging Research on Evaluation and Diagnosis of Bladder Outlet Obstruction in Women

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