Bladder Cancer, Disinfection Byproducts, and Markers of Genetic Susceptibility in a Case-control Study from Spain

Cantor, K P; Villanueva, Carolina; García‐Closas, Montserrat; Silverman, Daniel; Real, F.X.; Dosemeci, Mustafa; Malats, N.; Yeager, M J; Welch, Robert; Chanock, Stephen J.; Tardón, Adonina; García-Closas, Reina; Serra, Carla; Carrato, Alfredo; Castaño‐Vinyals, Gemma; Samanic, Claudine; Rothman, N.; Kogevinas, Manolis

doi:10.1097/00001648-200611001-00375

Cited by 15 publications

(8 citation statements)

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“…Although the acute benefits of drinking water disinfection are universally acknowledged, there is concern about adverse health risks due to long-term DBP exposure , . Epidemiology studies provide moderate evidence for DBP associations with adverse pregnancy outcomes – ; specific DBPs are mutagens, carcinogens, teratogens, or developmental toxicants – . In 2006, the U.S. Environmental Protection Agency (EPA) promulgated the Stage 2 Disinfectants/Disinfection Byproducts Rule .…”

Section: Introductionmentioning

confidence: 99%

Occurrence, Synthesis, and Mammalian Cell Cytotoxicity and Genotoxicity of Haloacetamides: An Emerging Class of Nitrogenous Drinking Water Disinfection Byproducts

Plewa

Muellner

Richardson

et al. 2007

Environ. Sci. Technol.

463

273

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The haloacetamides, a class of emerging nitrogenous drinking water disinfection byproduct (DBPs), were analyzed for their chronic cytotoxicity and for the induction of genomic DNA damage in Chinese hamster ovary cells. The rank order for cytotoxicity of 13 haloacetamides was DIAcAm > IAcAm > BAcAm > TBAcAm > BIAcAm > DBCAcAm > CIAcAm > BDCAcAm > DBAcAm > BCAcAm > CAcAm > DCAcAm > TCAcAm. The rank order of their genotoxicity was TBAcAm > DIAcAm approximately equal to IAcAm > BAcAm > DBCAcAm > BIAcAm > BDCAcAm > CIAcAm > BCAcAm > DBAcAm > CAcAm > TCAcAm. DCAcAm was not genotoxic. Cytotoxicity and genotoxicity were primarily determined by the leaving tendency of the halogens and followed the order I > Br > > Cl. With the exception of brominated trihaloacetamides, most of the toxicity rank order was consistent with structure-activity relationship expectations. For di- and trihaloacetamides, the presence of at least one good leaving halogen group (I or Br but not Cl) appears to be critical for significant toxic activity. Log P was not a factor for monohaloacetamides but may play a role in the genotoxicity of trihaloacetamides and possible activation of dihaloacetamides by intracellular GSH and -SH compounds.

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Section: Introductionmentioning

confidence: 99%

Occurrence, Synthesis, and Mammalian Cell Cytotoxicity and Genotoxicity of Haloacetamides: An Emerging Class of Nitrogenous Drinking Water Disinfection Byproducts

Plewa

Muellner

Richardson

et al. 2007

Environ. Sci. Technol.

463

273

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“…However, since the 1970s when scientists observed the formation of disinfection by-products (DBPs) during drinking water treatment and recognized their carcinogenic potential [Bellare et al, 1974;Rook, 1974], many studies have investigated the formation, occurrence, and health effects of DBPs. So far, over 600 kinds of DBPs have been identified [Richardson et al, 2007] and many of these are associated with cancers [IARC, 1995[IARC, , 2004Cantor et al, 2006;Bove et al, 2007;Villanueva et al, 2007], adverse pregnancy outcomes [Lewis et al, 2006[Lewis et al, , 2007Chisholm et al, 2008;Hoffman et al, 2008;Nieuwenhuijsen et al, 2008], and impaired male reproductive health [Fenster et al, 2003;Luben et al, 2007]. Potential human health risk of drinking water disinfection is now of great concern because of the daily and life-long exposure to DBPs in drinking water.…”

Section: Introductionmentioning

confidence: 99%

DNA damage and oxidative stress in human liver cell L‐02 caused by surface water extracts during drinking water treatment in a waterworks in China

Xie

Liu

Chen

et al. 2009

Environ and Mol Mutagen

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Because of the daily and life-long exposure to disinfection by-products formed during drinking water treatment, potential adverse human health risk of drinking water disinfection is of great concern. Toxicological studies have shown that drinking water treatment increases the genotoxicity of surface water. Drinking water treatment is comprised of different potabilization steps, which greatly influence the levels of genotoxic products in the surface water and thus may alter the toxicity and genotoxicity of surface water. The aim of the present study was to understand the influence of specific steps on toxicity and genotoxicity during the treatment of surface water in a water treatment plant using liquid chlorine as the disinfectant in China. An integrated approach of the comet and oxidative stress assays was used in the study, and the results showed that both the prechlorination and postchlorination steps increased DNA damage and oxidative stress caused by water extracts in human derived L-02 cells while the tube settling and filtration steps had the opposite effect. This research also highlighted the usefulness of an integrated approach of the comet and oxidative stress assays in evaluating the genotoxicity of surface water during drinking water treatment.

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“…with none of the associations showing a dose-response pattern. Further analysis showed that the dose-response relationship was found for persons with two deleted GSTT1-1 alleles (-/-), but not for persons with at least one non-deleted GSTT1-1 allele (+/+ or +/-) (Cantor et al, 2006). In all THM exposure categories, the risk of bladder cancer decreased with increasing water intake (Michaud et al, 2007).…”

Section: Menmentioning

confidence: 93%

Report: 20 Suspected Carcinogens Need More Research to Fill Knowledge Gaps

Eastman¹

2010

Oncology Times

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The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the World Health Organization concerning the legal status of any country, territory, city, or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. The mention of specific companies or of certain manufacturers' products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters.The expert group alone is responsible for the views expressed in this publication.

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Bladder Cancer, Disinfection Byproducts, and Markers of Genetic Susceptibility in a Case-control Study from Spain

Cited by 15 publications

References 0 publications

Occurrence, Synthesis, and Mammalian Cell Cytotoxicity and Genotoxicity of Haloacetamides: An Emerging Class of Nitrogenous Drinking Water Disinfection Byproducts

Occurrence, Synthesis, and Mammalian Cell Cytotoxicity and Genotoxicity of Haloacetamides: An Emerging Class of Nitrogenous Drinking Water Disinfection Byproducts

DNA damage and oxidative stress in human liver cell L‐02 caused by surface water extracts during drinking water treatment in a waterworks in China

Report: 20 Suspected Carcinogens Need More Research to Fill Knowledge Gaps

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