Black ginseng inhibits ethanol-induced teratogenesis in cultured mouse embryos through its effects on antioxidant activity

Lee, Se-Ra; Kim, Mi-Ra; Yon, Jung-Min; Baek, In-Jeoung; Park, Chun Gui; Lee, Beom Jun; Yun, Young Won; Nam, Sang-Yoon

doi:10.1016/j.tiv.2008.10.001

Cited by 40 publications

(29 citation statements)

References 47 publications

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“…Conversely, ginseng extract treatment increased CAT activity, with black ginseng treatment producing the greatest increase. These data were in line with previous reports suggesting that ginseng extracts have substantial antioxidant activity [25][26][27]. The antioxidant activity of black ginseng in particular may be due to hydroxyl radical removal by black ginseng-specific ginsenosides including Rg 3 , Rk 1 , and Rg 5 [28], in addition to the anti-cytotoxic activity of Rg 3 [29] and neuroprotective effects of Rg 3 after cerebral ischemia [30].…”

Section: Antioxidant Effects Of Ginseng Extractssupporting

confidence: 92%

Effect of Black Ginseng on Memory Improvement in the Amnesic Mice Induced by Scopolamine

Lee¹,

Yun²,

Liu³

et al. 2010

Journal of Ginseng Research

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:This study compared the effects of black, white, and red ginseng extracts (WGE, RGE, BGE, 200 mg/kg, p.o.) on learning and memory deficits associated with scopolamine treatment (SCOP, 2 mg/kg, i.p.). Tacrine (THA, 10 mg/kg, p.o.) was used as a positive control. Ginseng significantly reversed SCOP-induced memory impairment in the passiveavoidance test and also reduced escape latency in training trials of the Morris water maze test. The increased acetylcholinesterase (AChE) activity produced by SCOP was significantly inhibited by WGE and RGE (p<0.001). SCOP administration had no effect on choline acetyltransferase (ChAT) activity, but RGE and BGE significantly increased ChAT activity (p<0.05). SCOP administration increased oxidative damage in the brain. Treatment of amnesic mice with ginseng extracts decreased malondialdehyde (MDA) levels and restored superoxide dismutase (SOD) and catalase (CAT) activity to control levels. These results suggest that black ginseng enhances cognitive activity by regulation of cholinergic enzymes and antioxidant systems.

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Section: Antioxidant Effects Of Ginseng Extractssupporting

confidence: 92%

Effect of Black Ginseng on Memory Improvement in the Amnesic Mice Induced by Scopolamine

Lee¹,

Yun²,

Liu³

et al. 2010

Journal of Ginseng Research

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“…The morphological scores were significantly increased compared with the control. The mRNA levels of GPx, phospholipid hydroperoxide, and selenoprotein were significantly improved compared with the alcohol-treated embryos [95]. Moreover, ginseng had protective effects from alcohol-induced gastric damages in rats.…”

Section: Panax Ginsengmentioning

confidence: 85%

“…Mice Amelioration of liver and brain alcohol injuries through decreasing L-γ-glutamyl transpeptidase and butyryl cholinesterase [76] Humans Decreased signs and symptoms of alcohol hangover [79] Essential oil and citral Mice Hepatoprotective property against AFLD by decreasing levels of D-glucurono-6,3-lactone, glycerol-3-phosphate, and pyruvic acid in serum [80] Opuntia ficus-indica Flavones and phenolics Cladode Humans Reduced hangover symptoms by inflammatory mediator production inhibition [88,89] Rats Suppression of liver damage induced by alcohol through ending free radical chain reactions or enhancing the endogenous antioxidant activities [90] Panax ginseng Ginsenosides Root Humans Relief from hangover symptoms through reduced expiratory and plasma alcohol levels and hangover severity [91] Linoleic acid Mice Alleviation of hangover through reduced alcohol and acetaldehyde levels and enhanced ADH and ALDH activities [92] Mice Suppressed alcohol-induced toxicity on male fertility [93] Ricefish Suppressed alcohol-induced toxicity on embryogenesis [94] Mouse embryos Suppressed alcohol-induced toxicity in the neurocranium through its effects on antioxidant activity [95] Rats Suppressed alcohol-induced toxicity in the gastric system via the restoration of heat-shock proteins [96] Hypericum perforatum Hypericin and hyperforin Leave and flowering tops Rats and mice Reduced voluntary alcohol intake in acute and chronic alcohol treatment through neurochemical mechanisms [101,104,105] Rats Attenuated alcohol withdrawal syndrome by inhibition of the effects on tremors and audiogenic seizures [102] Salvia miltiorrhiza…”

Section: -Gingerol Rhizomementioning

confidence: 99%

Natural Products for the Prevention and Treatment of Hangover and Alcohol Use Disorder

Wang

Zhang

et al. 2016

Molecules

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Alcoholic beverages such as beer, wine and spirits are widely consumed around the world. However, alcohol and its metabolite acetaldehyde are toxic and harmful to human beings. Chronic alcohol use disorder or occasional binge drinking can cause a wide range of health problems, such as hangover, liver damage and cancer. Some natural products such as traditional herbs, fruits, and vegetables might be potential dietary supplements or medicinal products for the prevention and treatment of the problems caused by excessive alcohol consumption. The aim of this review is to provide an overview of effective natural products for the prevention and treatment of hangover and alcohol use disorder, and special emphasis is paid to the possible functional component(s) and related mechanism(s) of action.

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“…Since the changes occurring in the activities of these enzymes can be considered a biomarker of antioxidant response under conditions of oxidative stress, the increased activity of these enzymes in FBG-treated HepG2 cells strongly suggests that FBG has antioxidant properties that function by simulating the activity of antioxidant enzymes in addition to directly scavenging ROS/free radicals. Lee et al (38), revealed that black ginseng has a protective effect on ethanol-induced teratogenesis through the augmentation of antioxidant activity in embryos.…”

Section: Discussionmentioning

confidence: 99%

Detoxifying effect of fermented black ginseng on H2O2-induced oxidative stress in HepG2 cells

Bak

Jeong

Kim

2014

International Journal of Molecular Medicine

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Abstract. Fermented black ginseng (FBG) is prepared by repeated steaming and drying processes with fresh ginseng followed by fermentation with Saccharomyces cerevisiae. It has recently been shown to have several bioactivities. FBG contains crude saponin (1,440 µg/ml), ginsenoside Rg2 (2.86 µg/ml), ginsenoside Rg3 (24.52 µg/ml), ginsenoside Rh1 (12.64 µg/ml), ginsenoside Rh2 (0.63 µg/ml) and ginsenoside Rf (1.32 µg/ml). The present study investigated the antioxidant defense properties of FBG against hydrogen peroxide (H 2 O 2 )-mediated oxidative stress in HepG2 human hepatocellular carcinoma cells. The increased production of reactive oxygen species (ROS) induced by H 2 O 2 was attenuated in a dose-dependent manner when the cells were pre-treated with FBG (10-50 µg/ml). FBG induced both the expression and activity of antioxidant enzymes, such as superoxide dismutase, catalase and glutathione peroxidase in the H 2 O 2 -treated HepG2 cells. The inhibitory effects of FBG on the phosphorylation of upstream mitogen-activated protein kinases (MAPKs), such as c-Jun N-terminal kinase, extracellular signal-regulated kinase and p38 were also observed. Overall, our results demonstrate that FBG protects HepG2 cells from oxidative stress through the induction of antioxidant enzyme activity and the inhibition of MAPK pathways.

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Black ginseng inhibits ethanol-induced teratogenesis in cultured mouse embryos through its effects on antioxidant activity

Cited by 40 publications

References 47 publications

Effect of Black Ginseng on Memory Improvement in the Amnesic Mice Induced by Scopolamine

Effect of Black Ginseng on Memory Improvement in the Amnesic Mice Induced by Scopolamine

Natural Products for the Prevention and Treatment of Hangover and Alcohol Use Disorder

Detoxifying effect of fermented black ginseng on H2O2-induced oxidative stress in HepG2 cells

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