Black Fungus: A Lethal Communal Issue After Winning the Life Battle Against COVID-19

Ahammed, Shaik Gundikota Javeed; Pradeepkumar, Bhupalam; Ahad, Hindustan Abdul; Chinthaginjala, Haranath; Rahamathulla, Syed; Yadav, Srividya

doi:10.13005/bpj/2306

Cited by 5 publications

(3 citation statements)

References 33 publications

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“…To ensure accuracy and reliability, all assays were conducted in triplicate. [21,26] Results And Discussion…”

Section: (3)mentioning

confidence: 99%

Empowering Topical Delivery: Box Behnken Design Optimization of Posaconazole Microsponge Hydrogel for Improved Management of Fungal Infections

Kuppala,

Prakash,

Devanna

2024

Int. J. Pharm. Sci. Drug Res.

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This study aimed to prepare Posaconazole (PNZ) microsponges and formulate them into a hydrogel, optimizing the drug-polymer ratio and other parameters using Design Expert’s Box Behnken Design. The microsponges were synthesized considering drug-polymer ratio, surfactant (PVA), and stirring speed as inputs, while the vesicular size and PNZ content were evaluated as dependent variables. The prepared microsponges were then merged into a hydrogel. Compatibility studies between the PNZ and excipients were conducted, and the physicochemical parameters of the microsponges and hydrogels were assessed. Statistical analysis was performed to evaluate variance among the factors. Microsponges formulated with a polymer ratio of 1:1 with PNZ (PM-3) exhibited favorable attributes, including smaller vesicular size, drug content, high % yield, % entrapment, and superior PNZ discharge profile. Scanning electron microscopy (SEM) confirmed the spherical morphology and porous structure of PM-3 microsponges, indicating their suitability for PNZ loading and release. In vitro release studies demonstrated rapid initial discharge followed by sustained release over 12 h for PM-3, indicating potential for optimized PNZ delivery. Viscosity studies revealed a higher viscosity of PM-3 gel compared to conventional gel, potentially enhancing adherence to the skin surface and PNZ absorption. Additionally, PM-3 exhibited superior antifungal activity in disk diffusion assays, indicating effective control of fungal growth. This study successfully developed PNZ-loaded microsponge hydrogels, showing promising utility in treating fungal infections. PM-3 formulation demonstrated superior characteristics, suggesting its potential for optimized PNZ delivery and therapeutic outcomes.

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“…To ensure accuracy and reliability, all assays were conducted in triplicate. [21,26] Results And Discussion…”

Section: (3)mentioning

confidence: 99%

Empowering Topical Delivery: Box Behnken Design Optimization of Posaconazole Microsponge Hydrogel for Improved Management of Fungal Infections

Kuppala,

Prakash,

Devanna

2024

Int. J. Pharm. Sci. Drug Res.

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“…[29][30][31][32] 33 Healthcare experts are currently looking for interventions that will help enhance clinical outcomes and lower the costs associated with providing healthcare. [34][35][36][37]…”

Section: Length Of Hospital Stay (Lhs)mentioning

confidence: 99%

Age and Gender-wise Distribution, Social History, and Length of Hospital Stay of Cardiovascular Patients with Drug-related Problems

Mohammad Umar

2023

CHCMJ

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A patient's quality of life, mortality, and morbidity are all impacted by drug-related problems. These problems can occur at any stage of the prescription, transcription, distribution, and administration of medications. Research into the frequency, manifestations, patterns, and treatment implications of drug-related problems in cardiovascular patients will advance, leading to a rise in patient safety and recovery.Methods: A potential interventional trial was discussed over the course of 8 months in the cardiology and tertiary care medical departments. The required demographic and clinker data were acquired from the case files.Results: In this study, 246 cardiovascular patients were enrolled, and 1567 drug-related problems (DRPs) were found, with reference to the inclusion and exclusion conditions. Conclusion:In conclusion, population ageing and growth contribute to the global increase in CVD fatalities. Alcohol and tobacco use are linked to CVDs, with harmful effects observed at high consumption levels. Excessive alcohol and smoking increase blood pressure, cholesterol, and the risk of stroke and heart failure. However, moderate drinking poses minimal risks and may have some benefits. Efforts to reduce smoking and excessive drinking are essential for improving cardiovascular health and reducing CVD-related risks.

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“…5,6 Pharmacovigilance is the science and practice of identifying, evaluating, comprehending, and preventing side effects and other problems associated with drugs or vaccines. 7,8 Before they are officially approved for use, all medications and vaccines go through extensive testing for both safety and efficacy through clinical trials. 9,10 Recognized as a frequent reason for hospital admissions, adverse drug reactions (ADRs) place a heavy financial burden on hospitals.…”

Section: Introductionmentioning

confidence: 99%

Monitoring Adverse Medication Reactions: Aiding Pharmacovigilance at a Hospital Providing Secondary Care

Teja¹,

Reddy²,

Devanna³

2023

Int J. Pharm. Investigation

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Introduction: Although adverse drug reaction (ADR) monitoring is widely known, it is not practised in underdeveloped nations due to a lack of awareness and the absence of a central coordinating agency. The recent implementation of the National Pharmacovigilance Program has encouraged ADR monitoring in some centres. Aim: The purpose of this study was to evaluate the sternness of described ADRs, the additional financial cost associated with ADRs, and the present load of ADRs at the RDT hospital in Battalapalli, AP, India. Materials and Methods: Over 26 months of hospital admissions of patients, which were managed by hospital staff, a prospective, spontaneous reporting research was carried out. Results: 37 of the 74 adverse drug events (ADEs) that were reported by 56 individuals were indeed ADRs. There were 521 patients admitted, and 9.7% of those ADRs occurred during hospitalisation. Males (56%) had ADRs more often than females (44%). During the hospital stay, no discernible difference between males and females was seen. ADR rates were 19, 20, and 61% for paediatric, geriatric, and adult patients. There were 88 minor responses or 53.7% of the total. The majority of patients (72.6%) recovered from the incident. The majority of the responses show that they were unexpected and possibly avoidable. Conclusion: According to the study's findings, 90% of ADRs might be prevented, saving the health system money and decreasing patient expenditures. To prevent unknown and severe ADRs, new medications should be continuously monitored.

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Black Fungus: A Lethal Communal Issue After Winning the Life Battle Against COVID-19

Cited by 5 publications

References 33 publications

Empowering Topical Delivery: Box Behnken Design Optimization of Posaconazole Microsponge Hydrogel for Improved Management of Fungal Infections

Empowering Topical Delivery: Box Behnken Design Optimization of Posaconazole Microsponge Hydrogel for Improved Management of Fungal Infections

Age and Gender-wise Distribution, Social History, and Length of Hospital Stay of Cardiovascular Patients with Drug-related Problems

Monitoring Adverse Medication Reactions: Aiding Pharmacovigilance at a Hospital Providing Secondary Care

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