Black bone disease of the foot. Minocycline related pigmentation

Middleton, Scott; Anakwe, Raymond; McKinley, John

doi:10.1016/j.fas.2011.01.011

Cited by 14 publications

(12 citation statements)

References 8 publications

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“…Severe pigmentary abnormalities in the joint occasionally occur after several specific conditions, such as ochronotic arthropathy due to alkaptonuria [ 1 – 3 ] and the use of drugs for Parkinson's disease [ 5 , 6 ] or antibiotics [ 7 – 9 ]. In this case, severe black colouration of the articular cartilage appears to have occurred due to haemosiderosis and lipofuscin deposition on the articular cartilage.…”

Section: Discussionmentioning

confidence: 99%

“…Mild discolouration of the articular cartilage is known to gradually occur during aging. However, pathological tissue pigmentation is occasionally induced under several specific conditions, including ochronotic arthritis accompanied by alkaptonuria [ 1 – 3 ], haemosiderosis [ 4 ], and the use of drugs for Parkinson's disease [ 5 , 6 ] or antibiotics [ 7 – 9 ]. In the present case, we performed total knee replacement (due to osteoarthritis) in a patient with recurrent haemarthrosis.…”

Section: Introductionmentioning

confidence: 99%

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Black Colouration of the Knee Articular Cartilage after Spontaneously Recurrent Haemarthrosis

Matsumoto

Ishimaru

Ogawa

et al. 2016

Case Reports in Orthopedics

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Mild discolouration of the articular cartilage is known to gradually occur during aging. However, pathological tissue pigmentation is occasionally induced under several specific conditions. In the present case, we performed total knee replacement in a patient with recurrent haemarthrosis. However, during the operation, we observed severe black colouration of the knee articular cartilage, due to the deposition of hemosiderin and lipofuscin. To our knowledge, this is the first report of severe cartilage pigmentation, due to hemosiderin and lipofuscin deposition in articular cartilage.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Black Colouration of the Knee Articular Cartilage after Spontaneously Recurrent Haemarthrosis

Matsumoto

Ishimaru

Ogawa

et al. 2016

Case Reports in Orthopedics

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“…We were able to find 16 reports of minocycline bone pigmentation in the orthopaedic literature. Sites reported include the knee joint surfaces,8–11 hip joint,8 ankle joint,8 femur,12 hip joint surfaces,13 clavicle,14 acromion,15 metacarpals,16 metatarsals,17 18 iliac crest15 19 and spine 19…”

Section: Discussionmentioning

confidence: 99%

“…These authors have reported a variety of bone pigmentations: usually black,11 15 16 18 19 but also blue-green,9 17 violet-black,10 or brown 8 13. For simplification, any minocycline-related pigmentation is referred to as black bone disease.…”

Section: Discussionmentioning

confidence: 99%

“…Such black bone encountered surgically for arthroplasty or deformity correction was noted to be of normal integrity with no consequences of implant loosening or non-union of fixation on follow-up 8 16–18. Concerned surgeons often sent off black bone for histological analysis, which revealed normal bone without any neoplastic or osteomyelitis pathology 8 10 13 15 17 18. UV light fluorescence was demonstrated on the specimens in some studies9 13 15 but was negative in others 10.…”

Section: Discussionmentioning

confidence: 99%

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Black bone disease in a healing fracture

et al. 2016

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Black bone disease refers to the hyperpigmentation of bone secondary to prolonged usage of minocycline. We present a report of a 34-year-old man who underwent femoral shaft fracture fixation complicated by deep infection requiring debridement. The implants were removed 10 months later after long-term treatment with minocycline and fracture union. A refracture of the femoral shaft occurred 2 days after implant removal and repeat fixation was required. Intraoperatively, abundant heavily pigmented and dark brown bone callus was noted over the old fracture site. There was no evidence of other bony pathology and the appearance was consistent with minocycline-associated pigmentation. As far as we are aware, this is the first case of black bone disease affecting callus within the interval period of bone healing. We also discuss the relevant literature on black bone disease to bring light on this rare entity that is an unwelcomed surprise to operating orthopaedic surgeons.

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