Black Colouration of the Knee Articular Cartilage after Spontaneously Recurrent Haemarthrosis

Abstract

Mild discolouration of the articular cartilage is known to gradually occur during aging. However, pathological tissue pigmentation is occasionally induced under several specific conditions. In the present case, we performed total knee replacement in a patient with recurrent haemarthrosis. However, during the operation, we observed severe black colouration of the knee articular cartilage, due to the deposition of hemosiderin and lipofuscin. To our knowledge, this is the first report of severe cartilage pigmentation, due to hemosiderin and lipofuscin deposition in articular cartilage.

Considerations in hiPSC-derived cartilage for articular cartilage repair

“…Furthermore, it may have a chemically reactive surface that can disturb cellular metabolism. Lipofuscin has been reported to accumulate in natural cartilage [ 38 ]. Although the effects of lipofuscin on cartilage metabolism are unknown, culture conditions that produce no lipofuscin should be used for repairing cartilage damage.…”

Black discoloration of the knee articular cartilage in a patient with pigmented villonodular synovitis: A case report

“…Pigmented villonodular synovitis is a proliferative disorder of the synovium with locally aggressive nature, and its etiology is unclear, although neoplasm, recurrent hemorrhage, and trauma have been reported as possible causes. 8,9 To our knowledge, there are no reports of severe articular surface, synovial, and meniscal pigmentation in patients with PVNS; however, certain conditions have been reported to cause severe articular cartilage and meniscal pigmentation abnormalities in patients, such as alkaptonuria (ochronosis) and use of antibiotics and drugs such as levodopa and methyldopa. [1][2][3][4][5][6][7] In 2016, Matsumoto et al reported black discoloration of the knee articular cartilage after spontaneous recurrent hemarthrosis in a patient and concluded that hemosiderin and lipofuscin accumulation due to recurrent hemarthrosis might increase black pigmentation of joint cartilage.…”

“…[1][2][3][4][5][6][7] In 2016, Matsumoto et al reported black discoloration of the knee articular cartilage after spontaneous recurrent hemarthrosis in a patient and concluded that hemosiderin and lipofuscin accumulation due to recurrent hemarthrosis might increase black pigmentation of joint cartilage. 9 They roll outed specific condition by histopathological examination. 9…”

Total knee replacement for ochronotic arthritis: A rare case report

“…Alkaptonuria is a rare autosomal recessive metabolic disorder caused by a deficiency in homogentisic acid oxidase, resulting in the accumulation of homogentisic acid in collagenous structures [1] , [2] . This causes the classic clinical triad of homogentisic aciduria (blackening of the urine after standing when oxidized or alkalinized); eumelanin-like pigmentation of the skin, sclera, cartilages, and other organs; and degenerative ochronotic arthropathies commonly appearing in the fourth decade of life [3] .…”

“…However, in some cases such as ochronotic arthritis, pathological tissue pigmentation can occur. Matsumoto et al reported black discoloration in the knee articular cartilage due to deposition of hemosiderin and lipofuscin caused by recurrent hemarthrosis [1] , [2] . In this case report, we present a case of ochronotic arthritis managed by TKR.…”