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Muratova, S. A.; Burkhanova, N. D.; Yugai, S. M.; Nikonovich, G. V.; Pulatova, Kh. P.; Рашидова, С. Ш.

doi:10.1023/a:1022625617610

Cited by 3 publications

(1 citation statement)

References 2 publications

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“…This factor may influence the stability of drugs on storage, which can (i) lead to an increase or decrease in the therapeutic efficacy and bioaccessibility and (ii) change the mechanism and degree of drug release from the given composition [1]. Such interactions can be absent or weak in the course of production and storage, while being more strongly manifested in the dissolution medium upon drug administration [2].…”

Section: Results and Discusisonmentioning

confidence: 99%

Influence of Various Pharmaceutical Factors on Drug Release from Matrix Tablets

et al. 2005

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The influence of various pharmaceutical factors on the release of active substances from matrix tablets based on interpolyelectrolyte complexes of poly(methacrylic acid) and poly(ethylene glycol) has been studied. By varying these factors, it is possible to control the drug release kinetics and create new medicinal forms with preset properties. The most important factors in this respect are the polymer fraction in the composition and the character of interaction between the active substance and matrix components.

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Section: Results and Discusisonmentioning

confidence: 99%

Influence of Various Pharmaceutical Factors on Drug Release from Matrix Tablets

et al. 2005

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Synthesis and Study of Properties of Polymer Complexes of Ethacyzin With Carbox-Ymethylcellulose

Хайтметова¹,

Шомуротов²,

Тураев³

2017

JCPRM

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Last years intensive researches on creation of new prolonged preparations on the basis of natural polymeric carriers with the improved physical and chemical and pharmacological properties have been conducted.One of approaches to the decision of the given problem is inclusion in a matrix of the polymeric carrier known medicinal preparations that will allow purposefully change their properties and activity. Natural polymers, in particular, polysaccharides, unlike synthetic polymers, are biocompatible and do not show collateral toxic effects in a contact with alive organism, and at the same time can improve bioavailability and prolonged action.Carboxymethylcellulose macromolecule (CMC) as the carrier for physiologically active substance has great value, thanking its properties such as non-toxicity, biodegradability and etc.With the purpose of obtaining of the prolonged preparation possessing anti-arrhythmic action, an interaction of Na-CMC with well known anti-arrhythmic preparation of ethacyzin hydrochloride (ETH) is investigated.Na-CMC having various molecular weight, received by hydrolysis of industrial Na-CMC was used as a polymeric carrier. It is shown, that by the variation of time and molar ratio of mineral acid of system during the process of hydrolysis creates possibility of regulation by the molecular characteristics of polymeric matrix of Na-CMC.For the first time, a process of synthesis of with the various contents of medicinal components is investigated at a variation of molecular structure of polymer of carrier Na-CMC.Pharmaco-toxicological studies showed that the polymeric complexes CMC with ETH possess low toxicity in a comparison with ethacyzin, and that, it shows expressed anti-arrhythmic action. An anti-arrhythmic activity of polymeric complex of CMC with ETH is equal to the activity of ETH, but considerably exceeds it on pharmacological properties that prove perspectives of the further researches on it as a prolonged anti-arrhythmic means.

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Studies on Interaction of Lidocaine Drug with Natural Cellulosic Fibres

Ashaduzzaman

Al-Rafin

Mustary

et al. 2016

IJPPE

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Abstract. Naturally engineered cellulosic fibres are of particular interest due to their diverse interfacial behavior; which could be well suited to operating interaction with functionalized drug. In the present work, interaction of Lidocaine (LC) hydrochloride, 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide was widely studied with cellulosic fibres i.e. cotton, jute and coir in presence of 0.1M HCl aqueous solution. In UV-Vis spectroscopy measurement, it is revealed that the highest interaction (adsorption 18 mg/g of fibres) of LC was occurred onto the cotton fibres surfaces from 3.5 mg/mL aqueous solution after 30 minutes gentle shaking. Kinetic studies in case of cotton fibres showed a linear relationship (R 2 = 0.9987) during desorption of LC upto 30 minutes at 25 o C temperature. The cotton fibres concentration was to be calculated 0.0085 g unit mol/L by considering the unit molecular weight of glucose unit. When 2.5 mg/mL (0.0108 g mol/L) LC drug solution was used then the ratio between glucose unit and LC drug was found to be 1.27. The interaction of LC was also increased direct-proportionally to the weight of cotton fibres. The resulting interaction phenomena of model LC would help us to deign dosage of anesthetic drug for specific physiological conditions.

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Untitled

Cited by 3 publications

References 2 publications

Influence of Various Pharmaceutical Factors on Drug Release from Matrix Tablets

Influence of Various Pharmaceutical Factors on Drug Release from Matrix Tablets

Synthesis and Study of Properties of Polymer Complexes of Ethacyzin With Carbox-Ymethylcellulose

Studies on Interaction of Lidocaine Drug with Natural Cellulosic Fibres

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