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Al-Allaf, Talal A.K.; Rashan, Luay; Steinborn, Dirk; Merzweiler, Kurt; Wagner, Christoph

doi:10.1023/a:1025407728854

Cited by 36 publications

(33 citation statements)

References 6 publications

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“…Ru 3 (CO) 12 (ABCR) and PdCl 2 (dppf)·CH 2 Cl 2 (ChemPur) were purchased and used as supplied; PdCl 2 (dppf)·CHCl 3 was prepared as described [34]. Solvents were dried by known procedures and stored under argon, most reactions were carried out using a standard Schlenk technique.…”

Section: General Informationmentioning

confidence: 99%

3,3’’-Bis(saccharin-6-ylmethyl)-1,1’:3’,1’’-terphenyl – Precursor of A New Tetradendate Bis-bridging Ligand

Buck¹,

Maas

2012

Zeitschrift Für Naturforschung B

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The title compound (H 2 tpsac) was synthesized from 6-bromosaccharin and 3,3 -bis(bromomethyl)-m-terphenyl. The ability of tpsac to serve as a tetradentate bis-bridging ligand was demonstrated by the formation of the dinuclear ruthenium(I,I) complexes [Ru 2 (CO) 5 (µ,µ-tpsac)] 2 , [Ru 2 (CO) 4 (µ,µ-tpsac)] n , [Ru 2 (CO) 4 (PPh 3 ) 2 (µ,µ-tpsac)], and [Ru 2 (CO) 5 (PPh 3 )(µ,µ-tpsac)]. An X-ray crystal structure analysis of [Ru 2 (CO) 4 (PPh 3 ) 2 (µ,µ-tpsac)] showed the head-to-tail (or 1,1) arrangement of the two saccharinate coordination sites.

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Section: General Informationmentioning

confidence: 99%

3,3’’-Bis(saccharin-6-ylmethyl)-1,1’:3’,1’’-terphenyl – Precursor of A New Tetradendate Bis-bridging Ligand

Buck¹,

Maas

2012

Zeitschrift Für Naturforschung B

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“…complex 26 with a yield of 24% (further X-ray details about complex 26 will be reported elsewhere in the literature). [14] IR (cm −1 ) of complexes 1-26: 1600-1650s (C O), 3100-3300 s, sharp (NH) and the frequency of water of solvation of complexes 1, 4, 5, 7-18, 20, 22-26 appeared as a broad band centered at ca 3450 cm …”

Section: Pt[(oocch 3 ) 2 ][(1r2r)-dach]} (14)mentioning

confidence: 99%

“…The latter appeared as strong bands with shoulders above 1600 cm −1 , being characteristic for CO of the carboxylato groups bonded to metals. [11,21] The 1 H-and 13 C-NMR spectral data of some selected complexes (1, 7, 15, 18, 19, 21, 23-26) were recorded (see Experimental). The 1 H-NMR spectra revealed the presence of signals due to the protons of the cyclohexyl and NH 2 groups of the (1R,2R)-1,2-diaminocyclohexane ligands and the carboxylato ligands (except for complex 1, having an oxalato ligand).…”

Section: Synthesis Of Complexesmentioning

confidence: 99%

“…As expected, the 13 C-NMR spectra of the complexes showed resonances of the cyclohexyl carbons and of the carboxylato carbons. [21,22] …”

Section: Synthesis Of Complexesmentioning

confidence: 99%

“…Some of these complexes are already undergoing preclinical and clinical trials aiming to find a more active and less toxic target complex and these have mostly been covered by a book [1] and recent reviews [2 -4] and articles. [5 -8] In continuation of our previous findings in this field of research; summarized in a review [9] and recently in a reported work, [10 -13] we attempted to synthesize a new set of palladium(II) and platinum(II) complex analogs to oxaliplatin, bearing the enantiomerically pure (1R,2R)-DACH ligand with different carboxylato groups, i.e. complexes 1-26 (Fig.…”

Section: Introductionmentioning

confidence: 99%

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Palladium(II) and platinum(II) complexes of (1R,2R)‐(−)‐1,2‐diaminocyclohexane (DACH) with various carboxylato ligands and their cytotoxicity evaluation

Al-Allaf

Rashan

Ketler³

et al. 2009

Applied Organom Chemis

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Exploring Raloxifene‐Based Metallodrugs: A Versatile Vector Combined with Platinum(II), Palladium(II) and Nickel(II) Dichlorides and Carborates against Triple‐Negative Breast Cancer

Kazimir,

Götze,

Lönnecke

et al. 2024

ChemMedChem

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Triple‐negative breast cancer (TNBC) poses challenges in therapy due to the absence of target expression such as estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Frequently, the treatment of TNBC involves the combination of several therapeutics. However, an enhanced therapeutic effect can be also achieved within a single molecule. The efficacy of raloxifene can be improved by designing a raloxifene‐based hybrid drug bearing a 2,2’‐bipyridine moiety (2). Integration of platinum(II), palladium(II), and nickel(II) complexes into this structure dramatically changed the cytotoxicity. The platinum(II) dichloride complex 3 did not demonstrate any activity, while palladium(II) and nickel(II) dichloride complexes 4 and 5 exhibited various cytotoxic behavior towards different types of hormone‐receptor positive (HR+) cancer and TNBC cell lines. The replacement of the two chlorido ligands in 3‒5 with a dicarbollide (carborate) ion [C2B9H11]2‐ resulted in reduced activity of compounds 6, 7, and 8. However, the palladacarborane complex 7 demonstrated higher selectivity towards TNBC. Furthermore, the mechanism of action was shifted from cytotoxic to explicitly cytostatic with detectable proliferation arrest and accelerated aging, characterized by senescence‐associated phenotype of TNBC cells. This study provides valuable insights into the development of hybrid therapeutics against TNBC.

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Cited by 36 publications

References 6 publications

3,3’’-Bis(saccharin-6-ylmethyl)-1,1’:3’,1’’-terphenyl – Precursor of A New Tetradendate Bis-bridging Ligand

3,3’’-Bis(saccharin-6-ylmethyl)-1,1’:3’,1’’-terphenyl – Precursor of A New Tetradendate Bis-bridging Ligand

Palladium(II) and platinum(II) complexes of (1R,2R)‐(−)‐1,2‐diaminocyclohexane (DACH) with various carboxylato ligands and their cytotoxicity evaluation

Exploring Raloxifene‐Based Metallodrugs: A Versatile Vector Combined with Platinum(II), Palladium(II) and Nickel(II) Dichlorides and Carborates against Triple‐Negative Breast Cancer

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