Biweekly gemcitabine therapy induces complete remission in cutaneous angiosarcoma resistant to multiple anticancer drugs

Kajihara, Ikko; Maeda, Saki; Yamada, Shinwa; Izumi, Kanako; Masuguchi, Shinichi; Fukushima, Satoshi; Jinnin, Masatoshi; Ihn, Hironobu

doi:10.1111/1346-8138.13077

Cited by 9 publications

(9 citation statements)

References 4 publications

(6 reference statements)

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“…Some agents reported to be efficacious for the treatment of angiosarcoma are paclitaxel, docetaxel, gemcitabine and bevacizumab . However, advanced angiosarcoma is frequently resistant to these agents, and new effective therapies need to be developed.…”

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confidence: 99%

Inhibition of heat shock protein 90 exerts an antitumour effect in angiosarcoma: involvement of the vascular endothelial growth factor signalling pathway

et al. 2017

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confidence: 99%

Inhibition of heat shock protein 90 exerts an antitumour effect in angiosarcoma: involvement of the vascular endothelial growth factor signalling pathway

et al. 2017

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“…Her serum cfDNA levels remained low during partial response. However, new bone metastasis lesions appeared, and biweekly gemcitabine therapy was initiated based on past reports . Two months after the initiation of biweekly gemcitabine treatment there were new bone metastases.…”

Section: Resultsmentioning

confidence: 99%

“…However, new bone metastasis lesions appeared, and biweekly gemcitabine therapy was initiated based on past reports. 20,21 Two months after the initiation of biweekly gemcitabine treatment there were new bone metastases. With the appearance of new metastatic lesions, her serum cfDNA levels increased slightly.…”

Section: Correlation Between Serum Cell-free Dna Levels and Clinical mentioning

confidence: 99%

Serum cell‐free DNA levels are a useful marker for extramammary Paget disease

et al. 2019

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Summary Background Although carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (CYFRA) are useful markers for extramammary Paget disease (EMPD), serum CEA and CYFRA levels are not elevated in most patients with EMPD without metastasis. Cell‐free (cf)DNA has attracted attention as an indicator of clinical conditions in several cancers. Objectives To identify further useful biomarkers for the detection of EMPD, including early lesions, and to study the clinical implications of cfDNA in EMPD. Methods cfDNA were isolated from serum of patients with EMPD with and without metastasis, and from healthy volunteers. Serum extracts were amplified using polymerase chain reaction. Results Serum cfDNA levels were significantly elevated in patients with EMPD with or without metastasis compared with those in healthy controls. Serum cfDNA was a better diagnostic marker for the presence of EMPD than serum CYFRA. Moreover, the postoperative serum cfDNA levels were significantly lower than those from the preoperative samples, and the change in serum cfDNA levels reflected the clinical courses of patients with EMPD treated with chemotherapy. Conclusions Taking the evidence together, serum cfDNA levels may be a useful marker for diagnosis and disease progression in EMPD. What's already known about this topic? Serum levels of carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (CYFRA) are not elevated in most patients with extramammary Paget disease (EMPD) without metastasis. Cell‐free (cf)DNA has attracted attention as an indicator of clinical conditions in several cancers. There are few reports of the clinical implications of cfDNA in dermatology. What does this study add? Serum cfDNA levels were significantly elevated in patients with EMPD with or without metastasis compared with those in healthy controls. Postoperative serum cfDNA levels were significantly lower than those from the preoperative samples. Changes in serum cfDNA levels reflected the clinical courses of patients with EMPD treated with chemotherapy. What is the translational message? Serum cfDNA levels in patients with EMPD are a useful marker for the detection of EMPD, including localized EMPD. Changes in serum cfDNA levels in an individual patient may reflect the clinical course of EMPD.

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“…Gemcitabine is known to have a high level of activity in leiomyosarcoma and modest activity in other soft tissue sarcomas. [2] A single report of a patient with a soft tissue angiosarcoma who achieved complete remission has been published in the literature [7]; however, whether complete remission can be achieved for UPS and other STS is yet to be reported. [8,9] To our knowledge, we report the first documented case of metastatic UPS that originated in the retroperitoneal area, wherein the patient achieved a complete radiographic response to a single-agent gemcitabine regimen.…”

Section: Discussionmentioning

confidence: 99%

Effective Treatment of Undiferentiated Pleomorphic Sarcoma Using Gemcitabine: A Case Report

Ünal¹

2018

TJ Oncol

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Undifferentiated pleomorphic sarcoma (UPS) is most frequently observed in the extremities but rarely in the retroperitoneum. The present treatment for patients with metastatic or unresectable UPS in the first-line setting includes doxorubicin administration with or without ifosfamide. We present a case of a 68-year-old woman who presented with a retroperitoneal giant mass. The patient underwent surgery, the mass was removed, and the final diagnosis was UPS. The postoperative stage included soft tissue metastases. After three cycles of gemcitabine chemotherapy, computed tomography findings revealed the absence of soft tissue metastases. The patient has remained on regular follow-up over the past two years since chemotherapy with no symptoms of disease recurrence. The findings of this case demonstrate that patients with retroperitoneal UPS may benefit from single-agent gemcitabine chemotherapy.

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Biweekly gemcitabine therapy induces complete remission in cutaneous angiosarcoma resistant to multiple anticancer drugs

Cited by 9 publications

References 4 publications

Inhibition of heat shock protein 90 exerts an antitumour effect in angiosarcoma: involvement of the vascular endothelial growth factor signalling pathway

Inhibition of heat shock protein 90 exerts an antitumour effect in angiosarcoma: involvement of the vascular endothelial growth factor signalling pathway

Serum cell‐free DNA levels are a useful marker for extramammary Paget disease

Effective Treatment of Undiferentiated Pleomorphic Sarcoma Using Gemcitabine: A Case Report

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