Biventricular myocardial function in Covid-19 recovered patients assessed by speckle tracking echocardiography: a prospective cohort echocardiography study

Tryfou, E; Kostakou, Peggy; Chasikidis, Christos G; Kostopoulos, Vassilios S; Serafetinidis, Ioannis I; Ferdianaki, Efterpi K; Mihas, Constantinos; Olympios, Christoforos; Kouris, Nikos T.

doi:10.1007/s10554-021-02498-4

Cited by 16 publications

(17 citation statements)

References 32 publications

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“…These data indicate that COVID-19 patients may have subclinical left ventricular dysfunction and that those that are critically ill may have a greater decline in cardiac dysfunction. These data are consistent with other studies that demonstrated a reduction in LVGLS in COVID-19 patients [ 16 , 17 ]. In addition, we found that a reduced LVGLS was associated with an increased risk for mortality.…”

Section: Discussionsupporting

confidence: 93%

Left Ventricular Global Longitudinal Strain in Patients With COVID-19 Infection

Bhatti¹,

Sanchez²,

Dhungana³

et al. 2022

Cureus

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Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2, is an ongoing pandemic that has affected millions globally. Many infected patients have been noted to have cardiovascular damage. Prior to the development of clinical symptoms, the use of transthoracic echocardiography, specifically with measurements of left ventricular global longitudinal strain (LVGLS), may provide an additional prognostic marker for patients infected with COVID-19. We sought to determine whether patients with COVID-19 and reduced LVGLS have an increased risk for mortality. The mean LVGLS was determined to be significantly lower in the non-survivors compared to the survivors (−11.6 ± 1.8 vs −15.4 ± 0.74, p<0.05). It should be noted, however, that even those that survived were found to have reduced LVGLS (<−18.5%). A multivariate logistic regression analysis was also performed that demonstrated a relationship between reduced LVGLS and an increased risk for mortality. Overall, our data indicate that COVID-19 patients may have subclinical left ventricular dysfunction, and that critically ill patients may have a greater decline in cardiac dysfunction.

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Section: Discussionsupporting

confidence: 93%

Left Ventricular Global Longitudinal Strain in Patients With COVID-19 Infection

Bhatti¹,

Sanchez²,

Dhungana³

et al. 2022

Cureus

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“…The findings of this late study are more similar to our study. Similar differences can be observed in more recent publications [ 39 – 42 ], with rates of subclinical ventricular in up to one in three hospitalized patients [ 40 ]. The most reasonable explanation for the discrepancies observed between series of post COVID-19 patients are the differences in the severity of the patients included in them.…”

Section: Discussionsupporting

confidence: 89%

“…It is notable that although some authors have reported major cardiac abnormalities after recovery of COVID-19 infection, such as depressed LVEF [45], pericarditis, and pericardial effusion [46,47], these findings have not been detected in most majority of publications to date [5,[36][37][38][39][40][41][42]. A possible explanation for these findings is that these are predominantly case reports or case series with small sample size.…”

Section: Discussionmentioning

confidence: 98%

Abnormal echocardiographic findings after COVID-19 infection: a multicenter registry

Picco¹,

Lépori

Galello³

et al. 2022

Int J Cardiovasc Imaging

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The Coronavirus Disease 2019 (COVID-19) pandemic has transformed health systems worldwide. There is conflicting data regarding the degree of cardiovascular involvement following infection. A registry was designed to evaluate the prevalence of echocardiographic abnormalities in adults recovered from COVID-19. We prospectively evaluated 595 participants (mean age 45.5 ± 14.9 years; 50.8% female) from 10 institutions in Argentina and Brazil. Median time between infection and evaluation was two months, and 82.5% of participants were not hospitalized for their infection. Echocardiographic studies were conducted with General Electric equipment; 2DE imaging and global longitudinal strain (GLS) of both ventricles were performed. A total of 61.7% of the participants denied relevant cardiovascular history and 41.8% had prolonged symptoms after resolution of COVID-19 infection. Mean left ventricular ejection fraction (LVEF) was 61.0 ± 5.5% overall. In patients without prior comorbidities, 8.2% had some echocardiographic abnormality: 5.7% had reduced GLS, 3.0% had a LVEF below normal range, and 1.1% had wall motion abnormalities. The right ventricle (RV) was dilated in 1.6% of participants, 3.1% had a reduced GLS, and 0.27% had reduced RV function. Mild pericardial effusion was observed in 0.82% of participants. Male patients were more likely to have new echocardiographic abnormalities (OR 2.82, p = 0.002). Time elapsed since infection resolution (p = 0.245), presence of symptoms (p = 0.927), or history of hospitalization during infection (p = 0.671) did not have any correlation with echocardiographic abnormalities. Cardiovascular abnormalities after COVID-19 infection are rare and usually mild, especially following mild infection, being a low GLS of left and right ventricle, the most common ones in our registry. Post COVID cardiac abnormalities may be more frequent among males. Supplementary Information The online version contains supplementary material available at 10.1007/s10554-022-02706-9.

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“…It has been postulated that SARS-CoV-2 receptor distributions between two ventricles are not equivalent, with the lateral segment of the left cardiac ventricle having the most viral receptors [10]. However, our ndings contrast with a study byTryfou et al which reported a signi cant decrease in RV-FWS values in severe COVID-19 subjects compared to the healthy population (− 18.17 ± − 3.32 vs. − 26.03 ± − 4.55%, p < 0.0001) [11]. Nevertheless, it is important to note that the echocardiograph measurement in the study as mentioned above was conducted 30 days after admission, while our study conducted the measurement after 12 weeks.…”

contrasting

confidence: 99%

Persistent Myocardial Dysfunction Assessed by Global Myocardial Strain in Covid-19 Recovered Patients with Cardiovascular Comorbidities at 3 Months after Acute Infection

Tanto

Sukmawan

Liastuti

et al. 2022

Preprint

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Background Previous studies reported the Coronavirus disease (COVID-19) has long implications, which involve multiple organs, including the cardiovascular system. This study aims to assess myocardial dysfunction by echocardiograph myocardial longitudinal strain Left ventricular-Global Longitudinal Strain (LV-GLS) and Right Ventricular-Free Wall Strain (RV-FWS) measurements as a marker for myocardial dysfunction and heart fibrosis. Additionally, we aim to identify admission factors that may serve as a predictor of long COVID syndrome. Methods This cross-sectional study assessed echocardiograph global longitudinal strain (GLS) values measurement done three months after initial hospitalization. Multivariate analysis was done to investigate admission factors associated with differences in GLS values. Results 100 subjects with cardiovascular comorbidities and prior COVID-19 infection were enrolled. Echocardiography examination showed lower GLS values in this group compared to the normal population. Demographic and risk factors-matched subjects without a history of COVID-19 (n = 31, Control 1) and healthy subjects (n-31, Control 2) were included as comparisons to validate GLS results. The case group had significantly lower LV-GLS values compared to other groups (p < 0.05, mean ± SD -16.17 ± 3.379, -19.48 ± 1.141, -21.48 ± 1.777 respectively for case, control one, and control two groups). Upon admission, a history of coronary artery disease was found to be associated with decreased LV GLS values in recovered COVID-19 patients with cardiovascular comorbidity. Conclusion LV GLS values significantly decreased in recovered COVID-19 patients with cardiovascular comorbidities. Upon admission, a history of CAD may predict cardiac long COVID-19 syndrome.

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Biventricular myocardial function in Covid-19 recovered patients assessed by speckle tracking echocardiography: a prospective cohort echocardiography study

Cited by 16 publications

References 32 publications

Left Ventricular Global Longitudinal Strain in Patients With COVID-19 Infection

Left Ventricular Global Longitudinal Strain in Patients With COVID-19 Infection

Abnormal echocardiographic findings after COVID-19 infection: a multicenter registry

Persistent Myocardial Dysfunction Assessed by Global Myocardial Strain in Covid-19 Recovered Patients with Cardiovascular Comorbidities at 3 Months after Acute Infection

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